Trichuris suis ova therapy for allergic rhinitis: A randomized, double-blind, placebo-controlled clinical trial

Bager, Peter; Arnved, J.; Rønborg, Steen; Wohlfahrt, Jan; Poulsen, Lars K.; Westergaard, Tine; Petersen, Henning Willads; Kristensen, Bjarne Winther; Thamsborg, Stig Milan; Roepstorff, Allan; Kapel, Christian M. O.; Melbye, Mads

doi:10.1016/j.jaci.2009.08.006

Cited by 169 publications

(155 citation statements)

References 62 publications

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“…42 If eosinophils are increased in ulcerative colitis, 23 how can these clinical observations be reconciled with the data herein? Eosinophil levels were not documented in the clinical trial.…”

Section: Il-5 Andmentioning

confidence: 82%

Exacerbation of Oxazolone Colitis by Infection with the Helminth Hymenolepis diminuta

Wang

Fernando²,

Leung³

et al. 2010

The American Journal of Pathology

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Section: Il-5 Andmentioning

confidence: 82%

Exacerbation of Oxazolone Colitis by Infection with the Helminth Hymenolepis diminuta

Wang

Fernando²,

Leung³

et al. 2010

The American Journal of Pathology

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“…Using the same dosing regimen Fleming et al (in press) obtained promising results on a few patients with multiple sclerosis. Unfortunately, T. suis does not seem to have any positive effect on pollen allergy patients (Bager et al, 2010).…”

Section: Immune Responses and Immunomodulationmentioning

confidence: 99%

Helminth parasites in pigs: New challenges in pig production and current research highlights

Roepstorff

Mejer

Nejsum

et al. 2011

Veterinary Parasitology

145

101

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a b s t r a c tHelminths in pigs have generally received little attention from veterinary parasitologists, despite Ascaris suum, Trichuris suis, and Oesophagostomum sp. being common worldwide. The present paper presents challenges and current research highlights connected with these parasites.In Danish swine herds, new indoor production systems may favour helminth transmission and growing knowledge on pasture survival and infectivity of A. suum and T. suis eggs indicates that they may constitute a serious threat to outdoor pig production. Furthermore, it is now evident that A. suum is zoonotic and the same may be true for T. suis. With these 'new' challenges and the economic impact of the infections, further research is warranted. Better understanding of host-parasite relationships and A. suum and T. suis egg ecology may also improve the understanding and control of human A. lumbricoides and T. trichiura infections.The population dynamics of the three parasites are well documented and may be used to study phenomena, such as predisposition and worm aggregation. Furthermore, better methods to recover larvae have provided tools for quantifying parasite transmission. Thus, an on-going study using helminth naïve tracer pigs has surprisingly demonstrated that soil infectivity with A. suum and T. suis increases during the first 2-3 years after pasture contamination.Though all three helminth species stimulate the Th2 arm of the immune system, Oesophagostomum seems weakly immunogenic, perhaps via specific modulation of the host immune system. A. suum and T. suis potently modulate the host immune response, up-regulating Th2 and down-regulating Th1. As a consequence, A. suum may compromise the efficacy of certain bacterial vaccines, whereas T. suis, which establish only short-term in humans, is a favourite candidate for down-regulating autoimmune Th1-related diseases in man.Some basic research findings have offered new possibilities for future sustainable control measures. For example, the heredity of host resistance to A. suum and T. suis is so high that breeding for resistant pigs may be a possibility. Experimental studies have demonstrated that fermentable dietary carbohydrates have an antagonistic effect on Oesophagostomum and to a lesser extent on T. suis and A. suum, whereas egg-destroying microfungi may be used to inactivate the hard-shelled A. suum and T. suis eggs in the environment.Helminth control in Denmark has previously relied solely on anthelmintic treatment in herds with low helminth transmission. When indoor transmission rates * Corresponding author. Tel.: +45 3533 2746. increase, or in outdoor herds with high pasture contamination levels, medication may advantageously be combined with sustainable control measures, such as selected pig genomes, bioactive forages, and egg-destroying microfungi.

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“…Additionally, skin prick test response positivity, total histamine levels, and grass pollen IgE levels did not change as a result of TSO treatment. The only improvement observed was a reduction in the use of tablet medication during the study, although the use of nasal spray and eye drops remained the same (15).…”

Section: Trichuris Suis For Allergic Rhinitismentioning

confidence: 94%

“…Modeled after the protective Crohn's disease and ulcerative colitis trials, participants in the double-blind, randomized, placebo-controlled study received either 2500 TSO or placebo every 21 days for a total of 24 weeks. Patients were exposed to helminths for at least 1 month before the peak of the pollen season (15).…”

Section: Trichuris Suis For Allergic Rhinitismentioning

confidence: 99%

The Use of Filariae as a Therapeutic Agent for Hypersensitivity Diseases

Evans¹

2014

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Trichuris suis ova therapy for allergic rhinitis: A randomized, double-blind, placebo-controlled clinical trial

Cited by 169 publications

References 62 publications

Exacerbation of Oxazolone Colitis by Infection with the Helminth Hymenolepis diminuta

Exacerbation of Oxazolone Colitis by Infection with the Helminth Hymenolepis diminuta

Helminth parasites in pigs: New challenges in pig production and current research highlights

The Use of Filariae as a Therapeutic Agent for Hypersensitivity Diseases

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