Trichomoniasis vaginalis

Serological Study with SolcoTrichovac, a Vaccine against Trichomonas vaginalis Infection in Women

“…The geometric mean of these titres increased from 1:56.4 before the vaccination to 1:320 after the vaccination, and it was still 1:140 1 year later. The dynamics of the serological immune response correlated with the clinical efficacy of this new vaccine.Various investigations have shown that Trichomonas vaginalis can only flourish in a specifically altered vaginal environment [1][2][3][5][6][7], A notable feature of this altered environment is the disappearance of the nor mal Doederlcin bacilli and the raised prevalence of aberrant, i.e., shortened and even coccoidal forms of Mactobacilli' which have largely lost the ability to produce lactic acid. The symbiotic relationship between these aberrant Mactobacilli' and T. vaginalis has been reported [4], The elimination of these bacilli from the vaginal environment is likely to endanger the existence of T. vaginalis [4], The inactivated vaccine SolcoTrichovac was prepared from 8 different strains of Lactobacillus acidophilus.…”

To the Issue of the Role Toxoplasma gondii in the Development of Schizophrenia

“…Сообщения о таких случаях пока-зали, что измененное психическое состояние может отмечаться в 60% случаев, при этом симптомы мо-гут включать в себя бред, слуховые галлюцинации и нарушение мышления [13]. Другие исследова-ния, в которых были обследованы здоровые взрос-лые, показали, что уровень сывороточных антител к Toxoplasma gondii коррелируется с изменениями поведения и психомоторных навыков [2].…”

“…Затем было проведено еще 54 исследования, среди кото-рых 49 сообщили, что люди с шизофренией и дру-гими психозами имели более высокие титры анти-тел к Toxoplasma gondii по сравнению с контроль-ной группой. [13,27]. Интерес представляют дан-ные анализа антител у лиц еще до начала заболе-вания.…”

Effects of Vaccination with SolcoTrichovac on the Vaginal Flora and the Morphology of the Doederlein Bacilli

“…One injection dose of 0.5 ml contains a total of 7 X 109 such lactobacilli. Vaccination with this vaccine induces the production of antibodies which are presumed to exert the following effects in man [1][2][3][4][5]: (1) improvement of the general immune defence against pathogens in the vagina, especially against Tricho monas vaginalis; (2) inhibition and elimination of altered lactobacilli which are found in the vagina in the presence of pathogenic bacteria and protozoa: (3) normalisation of the vaginal flora, i.e., re-establishment of the Doeder lein flora and normalisation of the vaginal milieu and pH.…”