Social media platforms, such as Twitter, are increasingly used by clinicians, including neurologists. Twitter represents a convenient means to reach out to fellow clinicians, researchers and patients alike. To make maximum use of these platforms, they must be used pragmatically and within the ambit of ethical principles that guide all medical practice. As neurologists, familiarizing ourselves with the technical know-how and potential uses of Twitter empowers us best to use it as a valuable clinical and networking tool. Twitter offers diverse formats for a neurologist, thus enabling the creation and dissemination of specific types of information in the form of tweetorials, journal clubs, conference-based tweeting, tweetchats and the like. In this practical step-by-step guide, we demonstrate how to harness Twitter for myriad academic uses.