Trichomonas vaginalis: Lifestyle, Cellular Biology, and Molecular Mechanisms of Pathogenesis

Riestra, Angelica M.; Miguel, Natalia de; Dessì, Daniele; Simões-Barbosa, Augusto; Mercer, Frances

doi:10.1007/978-3-030-80682-8_12

Cited by 9 publications

(26 citation statements)

References 314 publications

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“…Trichomoniasis is accompanied by a shift to vaginal dysbiosis in a clinical setting, and vaginal commensals have been shown to have significant effects on host and parasite responses in a laboratory setting ( 4 ). Furthermore, T. vaginalis is known for hosting two endosymbionts: a family of RNA viruses and Mycoplasma spp.…”

Section: Commentarymentioning

confidence: 99%

A Microbial Piñata: Bacterial Endosymbionts of Trichomonas vaginalis Come in Different Flavors

Aquino

Simões-Barbosa

2022

mBio

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The protozoan parasite Trichomonas vaginalis causes trichomoniasis, a prevalent human urogenital infection with significant morbidity that is commonly associated with vaginal dysbiosis. Exacerbation of T. vaginalis pathogenicity has been related to endosymbionts, including mycoplasma, and thought for a while to be solely attributable to Mycoplasma hominis .

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Section: Commentarymentioning

confidence: 99%

A Microbial Piñata: Bacterial Endosymbionts of Trichomonas vaginalis Come in Different Flavors

Aquino

Simões-Barbosa

2022

mBio

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“…It presents in the form of a trophozoite. However, the parasite cell can mutate to an amoeboid or pseudocysts appearance when attaching to surfaces of the host epithelium [1,2,3]. It measures approximately 10 µm in length by 7 µm in width [1,4].…”

Section: Introductionmentioning

confidence: 99%

“…It measures approximately 10 µm in length by 7 µm in width [1,4]. This protozoan has four unequal flagella that originate from the same point, an undulating membrane which brings mobility, and a rigid structure that projects through the centre of the cell to the posterior end called the axostyle [1,2,3,5]. The entire cell surface is capable of performing phagocytosis of bacteria, leukocytes and other particles.…”

Section: Introductionmentioning

confidence: 99%

“…Trichomoniasis is an infection of the urogenital tract caused by Trichomonas vaginalis, causing vulvovaginitis and cervicitis in women [3,6]. In men, it can cause urethritis, epididymitis and prostatitis [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…After infection, individuals may show symptoms between 5 and 28 days [5]. Trichomonas vaginalis infection is associated with an increased risk of cervical cancer, premature birth and increased risk for HIV infection [2,3,5].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Three Diagnostic Methods for Trichomonas vaginalis Detection in a Low-Resource Setting

Machado

Norberg²,

Norberg³

et al. 2023

JAMMR

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Aims: To comparatively evaluate the efficiency of three simple trichomoniasis diagnostic techniques in a low-resource setting at the Baixada Fluminense region, Province of Rio de Janeiro, Brazil. Place and Duration of Study: The sample was obtained from the medical records of women attending the Iguaçu University Clinic's Gynaecology Outpatient Clinic from January to December 2020. The sample consisted of medical records of 135 women aged 17 to 78 years. Methodology: With the aid of a sterile and disposable bi-valve speculum, vaginal secretion was collected with a swab from the vaginal sac. The secretion was used for smears in two slides for wet mount examination and Papanicolaou staining and then seeded in a tube with 6 ml of Diamond's culture medium. Results: The results showed that among the 135 women with clinical signs of vulvovaginitis, 65 (48.15%) were infected by Trichomonas vaginalis. The positivity rates displayed significant differences according to the detection methods used. Wet mount examination and Papanicolaou exams were less efficient, detecting only 7.7% of total infections confirmed by the culture in Diamond's medium. Conclusion: The analysis of the results allowed an update in the detection protocol of Trichomonas vaginalis infections in the Gynaecology Outpatient Clinic of the Iguaçu University. Papanicolaou test was eliminated from the protocol since it requires more resources than the wet mount examination. Wet mount examination was maintained because it detects part of the Trichomonas vaginalis infections at the time of medical attending, following the core principle of the syndromic approach indicated by WHO, but with greater efficacy than the diagnostic determination based on signs and symptoms. Culture by Diamond’s medium proved to be one of the best options for low-resource settings when compared to other detection methods of T. vaginalis analyzed in the current scientific literature, with an acceptable detection rate, only lower than sophisticated and high-cost methods.

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Trichomonas vaginalis and Cancer: Its Role in Cervical and Prostate Cancer Development

Benavides-Suárez

2024

Pathogens Associated With the Development of Cancer in Humans

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Trichomonas vaginalis: Lifestyle, Cellular Biology, and Molecular Mechanisms of Pathogenesis

Cited by 9 publications

References 314 publications

A Microbial Piñata: Bacterial Endosymbionts of Trichomonas vaginalis Come in Different Flavors

A Microbial Piñata: Bacterial Endosymbionts of Trichomonas vaginalis Come in Different Flavors

Comparison of Three Diagnostic Methods for Trichomonas vaginalis Detection in a Low-Resource Setting

Trichomonas vaginalis and Cancer: Its Role in Cervical and Prostate Cancer Development

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