Trichodysplasia spinulosa in a bone marrow transplant recipient: A case report

Rodriguez-Bolanos, Fabian; Rosen, Cheryl F.; Kamil, Zaid K Saeed

doi:10.1177/2050313x221093452

Cited by 1 publication

(1 citation statement)

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“…Trichodysplasia spinulosa is a rare disease primarily described in immunocompromised patients, commonly following solid organ transplant, but also in patients with immunosuppression due to medications, human immunodeficiency virus, bone marrow transplant, and cancer. 1,2 TS is caused by TS-associated polyomavirus (TSPyV), a deoxyribonucleic acid (DNA) virus which was discovered in the keratotic spines of a patient with TS. 3 Like BK and John Cunningham (JC) polyomaviruses, TSPyV becomes pathogenic in a small percentage of immunosuppressed patients.…”

Section: Discussionmentioning

confidence: 99%

Keratotic papules on the face, trunk, and extremities of a young girl

O'Brian

Gao

Vandergriff

et al. 2023

Pediatric Dermatology

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A 5-year-old girl with a 1-year history of a heart transplant, on immunosuppression with tacrolimus and mycophenolate mofetil and oral valganciclovir for cytomegalovirus prophylaxis, presented with a papular eruption on her face, trunk, and extremities. The lesions were first noted 7 months after her transplant and had spread. There was no associated pain, pruritus, or systemic symptoms such as fever, fatigue, night sweats, or weight loss. On physical examination, numerous hyperpigmented to skin-colored folliculocentric papules with central white keratotic projections were noted on her face, ears, trunk, and extremities, with increased concentration around the patient's nose (Figures 1 and 2). In addition to keratotic spicules, pink to skincolored papules with scale were noted on the patient's lower extremities (Figure 2). A punch biopsy was obtained from a lesion on the lower extremities (Figure 3).

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Section: Discussionmentioning

confidence: 99%