Trichodermaloids A–C, Cadinane Sesquiterpenes from a Marine Sponge Symbiotic <i>Trichoderma</i> sp. SM16 Fungus

Cui, Jie; Shang, Ru‐Yi; Sun, Ming; Li, Yixuan; Liu, Hongyan; Lin, Hou‐Wen

doi:10.1002/cbdv.202000036

Cited by 18 publications

(16 citation statements)

References 13 publications

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“…The cytotoxicities of cadinane sesquiterpenes 38-43 were evaluated against NCIH-460, NCI-H929, and SW620 cell lines (Cui et al, 2020). In contrast to the known compounds 41-43, the newly reported sesquiterpenes 38-40 showed more potent cytotoxicities, with IC 50 s of 6.8-12.7 µM.…”

Section: Anticancer Activitiesmentioning

confidence: 99%

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Trichoderma: A Treasure House of Structurally Diverse Secondary Metabolites With Medicinal Importance

Zhang

Tang²,

Huang

et al. 2021

Front. Microbiol.

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Fungi play an irreplaceable role in drug discovery in the course of human history, as they possess unique abilities to synthesize diverse specialized metabolites with significant medicinal potential. Trichoderma are well-studied filamentous fungi generally observed in nature, which are widely marketed as biocontrol agents. The secondary metabolites produced by Trichoderma have gained extensive attention since they possess attractive chemical structures with remarkable biological activities. A large number of metabolites have been isolated from Trichoderma species in recent years. A previous review by Reino et al. summarized 186 compounds isolated from Trichoderma as well as their biological activities up to 2008. To update the relevant list of reviews of secondary metabolites produced from Trichoderma sp., we provide a comprehensive overview in regard to the newly described metabolites of Trichoderma from the beginning of 2009 to the end of 2020, with emphasis on their chemistry and various bioactivities. A total of 203 compounds with considerable bioactivities are included in this review, which is worth expecting for the discovery of new drug leads and agrochemicals in the foreseeable future. Moreover, new strategies for discovering secondary metabolites of Trichoderma in recent years are also discussed herein.

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Section: Anticancer Activitiesmentioning

confidence: 99%

“…three new cadinane-type sesquiterpenes, i.e., trichodermaloids A-C (38-40), and three known ones, i.e., aspergilloid G (41), rhinomilisin E (42), and rhinomilisin G (43), were characterized from the marine sponge-derived fungus Trichoderma sp. SM16 (Cui et al, 2020).…”

Section: Cadinane Sesquiterpenesmentioning

confidence: 99%

Trichoderma: A Treasure House of Structurally Diverse Secondary Metabolites With Medicinal Importance

Zhang

Tang²,

Huang

et al. 2021

Front. Microbiol.

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“…SM16 isolated from the sponge Dysidea sp. [ 159 ]. Therefore, it is not unlikely that in some cases associated microorganisms are the actual producers of the detected sesquiterpenes.…”

Section: Specificity and Phylogenetic Relevance Of Sponge Compoundsmentioning

confidence: 99%

A Soft Spot for Chemistry–Current Taxonomic and Evolutionary Implications of Sponge Secondary Metabolite Distribution

et al. 2021

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Marine sponges are the most prolific marine sources for discovery of novel bioactive compounds. Sponge secondary metabolites are sought-after for their potential in pharmaceutical applications, and in the past, they were also used as taxonomic markers alongside the difficult and homoplasy-prone sponge morphology for species delineation (chemotaxonomy). The understanding of phylogenetic distribution and distinctiveness of metabolites to sponge lineages is pivotal to reveal pathways and evolution of compound production in sponges. This benefits the discovery rate and yield of bioprospecting for novel marine natural products by identifying lineages with high potential of being new sources of valuable sponge compounds. In this review, we summarize the current biochemical data on sponges and compare the metabolite distribution against a sponge phylogeny. We assess compound specificity to lineages, potential convergences, and suitability as diagnostic phylogenetic markers. Our study finds compound distribution corroborating current (molecular) phylogenetic hypotheses, which include yet unaccepted polyphyly of several demosponge orders and families. Likewise, several compounds and compound groups display a high degree of lineage specificity, which suggests homologous biosynthetic pathways among their taxa, which identifies yet unstudied species of this lineage as promising bioprospecting targets.

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“…In our continuing research for unique and biologically active natural products from marine sponges, [18–21] chemical investigation of a marine sponge of genus Petrosia resulted in the isolation of three new polyacetylenes with vicinal diol, pellynols P–R ( 1 – 3 ), and one known polyacetylene, pellynol H ( 4 ) ( Figure 1). Herein, the details of isolation, structure elucidation, and cytotoxicity of these polyacetylenes are reported.…”

Section: Introductionmentioning

confidence: 99%

New Bioactive Polyacetylenes from the Marine Sponge Petrosia sp.

Liu

Ding

Wang

et al. 2022

Chemistry & Biodiversity

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Three new polyacetylenes, pellynols P (1), Q (2), and R (3) were isolated from the marine sponge Petrosia sp., along with the known compound pellynol H (4). Their structures were determined by analyses of extensive NMR, HR‐MS, and ESI‐MS/MS data. All compounds displayed potent cytotoxicities against human hepatocellular carcinoma HepG2, human melanoma A375, and human colorectal carcinoma HT29 cell lines with IC50 values at the range of 1.4–4.4 μM.

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Trichodermaloids A–C, Cadinane Sesquiterpenes from a Marine Sponge Symbiotic Trichoderma sp. SM16 Fungus

Cited by 18 publications

References 13 publications

Trichoderma: A Treasure House of Structurally Diverse Secondary Metabolites With Medicinal Importance

Trichoderma: A Treasure House of Structurally Diverse Secondary Metabolites With Medicinal Importance

A Soft Spot for Chemistry–Current Taxonomic and Evolutionary Implications of Sponge Secondary Metabolite Distribution

New Bioactive Polyacetylenes from the Marine Sponge Petrosia sp.

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