Trichoderma viride bioactive peptaibol induces apoptosis in Aspergillus niger infecting tilapia in fish farms

Gamal, Marwa; Zaid, Mohamed Abou; Mourad, Iman Kamel Abou; Kareem, Hussein Abd El; Gomaa, Ola M.

doi:10.1016/j.aquaculture.2021.737474

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…Trichoderma spp. produce a wide range of antibiotic substances [ 99 , 100 ]. Active substances produced by Trichoderma, such as harzianic acid, have been shown to reduce Aspergillus growth and AF production, or possibly inhibit their synthesis [ 99 , 100 ].…”

Section: Methodsmentioning

confidence: 99%

“…produce a wide range of antibiotic substances [ 99 , 100 ]. Active substances produced by Trichoderma, such as harzianic acid, have been shown to reduce Aspergillus growth and AF production, or possibly inhibit their synthesis [ 99 , 100 ]. The inhibition of different fungal species by T. harzianum is comparable and more sustainable and may even be more effective than chemical fungicides.…”

Section: Methodsmentioning

confidence: 99%

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Endocrine Effect of Some Mycotoxins on Humans: A Clinical Review of the Ways to Mitigate the Action of Mycotoxins

Kościelecka,

Kuć,

Kubik-Machura

et al. 2023

Toxins

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Fungi such as Aspergillus spp. and Fusarium spp., which are commonly found in the environment, pose a serious global health problem. This study aims to present the results of epidemiological studies, including clinical cases, on the relationship between human exposure to some mycotoxins, especially zearalenone and aflatoxin, and the occurrence of reproductive disorders. In addition, examples of methods to reduce human exposure to mycotoxins are presented. In March 2023, various databases (PubMed, Google Scholar, EMBASE and Web of Science) were systematically searched using Google Chrome to identify studies evaluating the association between exposure to mycotoxins and the occurrence of complications related to impaired fertility or cancer incidence. The analysed data indicate that exposure to the evaluated mycotoxins is widespread and correlates strongly with precocious puberty, reduced fertility and increased cancer incidence in women and men worldwide. There is evidence to suggest that exposure to the Aspergillus mycotoxin aflatoxin (AF) during pregnancy can impair intrauterine foetal growth, promote neonatal jaundice and cause perinatal death and preterm birth. In contrast, exposure to the Fusarium mycotoxin zearalenone (ZEA) leads to precocious sexual development, infertility, the development of malformations and the development of breast cancer. Unfortunately, the development of methods (biological, chemical or physical) to completely eliminate exposure to mycotoxins has limited practical application. The threat to human health from mycotoxins is real and further research is needed to improve our knowledge and specific public health interventions.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Endocrine Effect of Some Mycotoxins on Humans: A Clinical Review of the Ways to Mitigate the Action of Mycotoxins

Kościelecka,

Kuć,

Kubik-Machura

et al. 2023

Toxins

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“…The active substances produced by Trichoderma have shown to reduce Aspergillus growth and subsequently AFs production, or possibly to degrade AFs rather than to inhibit their synthesis ( Gamal et al, 2022 ; Ren et al, 2022 ).…”

Section: Advanced Mycotoxin Reduction With Biological Controlmentioning

confidence: 99%

Advanced mycotoxin control and decontamination techniques in view of an increased aflatoxin risk in Europe due to climate change

et al. 2023

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Aflatoxins are toxic secondary metabolites produced by Aspergillus spp. found in staple food and feed commodities worldwide. Aflatoxins are carcinogenic, teratogenic, and mutagenic, and pose a serious threat to the health of both humans and animals. The global economy and trade are significantly affected as well. Various models and datasets related to aflatoxins in maize have been developed and used but have not yet been linked. The prevention of crop loss due to aflatoxin contamination is complex and challenging. Hence, the set-up of advanced decontamination is crucial to cope with the challenge of climate change, growing population, unstable political scenarios, and food security problems also in European countries. After harvest, decontamination methods can be applied during transport, storage, or processing, but their application for aflatoxin reduction is still limited. Therefore, this review aims to investigate the effects of environmental factors on aflatoxin production because of climate change and to critically discuss the present-day and novel decontamination techniques to unravel gaps and limitations to propose them as a tool to tackle an increased aflatoxin risk in Europe.

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“…Fungi of the genus Trichoderma are widely distributed and readily collected in nature. Some species such as Trichoderma harzianum and Trichoderma viride produce a wide range of enzymes and bioactive peptaibols and have been developed as biocontrol agents against fungal diseases of plants. − Trichoderma koningiopsis is a new species found during the investigation of Trichoderma resources in East China in 2010 . Its main metabolites are terpenoids and polyketides, some of which exhibit plant growth regulatory − and antimicrobial activities. − However, determination of the relative and absolute configurations of these polyketides is difficult because of their overlapped signals and isolated chiral centers, and many of them have not been determined, such as the case with koninginin B, 14-hydroxykoninginin B, koningiopisin D, and trichodermatides E and F. − Thus, the isolation and structural identification of these polyketides remains a challenge and needs further study by chemists. − …”

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confidence: 99%

Polyketides with Anti-Inflammatory Activity from Trichoderma koningiopsis, a Rhizosphere Fungus from the Medicinal Plant Polygonum paleaceum

Liping

Wei

et al. 2023

J. Nat. Prod.

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Twelve new fungal polyketides, koningiopisins I–P (1–8) and trichoketides C–F (9–12), together with six known congeners (13–18), were isolated from Trichoderma koningiopsis, a rhizosphere fungus obtained from the medicinal plant Polygonum paleaceum. Their structures and absolute configurations were established by spectroscopic analysis, single-crystal X-ray diffraction, the modified Mosher’s method, chemical derivatization, the octant rule, and 13C NMR and ECD calculations. Compounds 1–5 are tricyclic polyketides possessing an octahydrochromene framework with a 6,8-dioxabicyclo[3.2.1]octane core. Compounds 7 and 8 contain a unique ketone carbonyl group at C-7 and differ from other members of this group of compounds with the ketone carbonyl group at C-1. Compounds 1, 2, and 13 showed inhibitory activity on LPS-induced BV-2 cells on NO production with IC50 values of 14 ± 1, 3.0 ± 0.5, and 8.9 ± 2.7 μM, respectively.

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Trichoderma viride bioactive peptaibol induces apoptosis in Aspergillus niger infecting tilapia in fish farms

Cited by 5 publications

References 22 publications

Endocrine Effect of Some Mycotoxins on Humans: A Clinical Review of the Ways to Mitigate the Action of Mycotoxins

Endocrine Effect of Some Mycotoxins on Humans: A Clinical Review of the Ways to Mitigate the Action of Mycotoxins

Advanced mycotoxin control and decontamination techniques in view of an increased aflatoxin risk in Europe due to climate change

Polyketides with Anti-Inflammatory Activity from Trichoderma koningiopsis, a Rhizosphere Fungus from the Medicinal Plant Polygonum paleaceum

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