Trichoblastoma Is the Most Common Neoplasm Developed in Nevus Sebaceus of Jadassohn

Abstract

Nevus sebaceus of Jadassohn is a hamartoma that combines epidermal, follicular, sebaceous, and apocrine gland abnormalities. Classically, several types of cutaneous neoplasms have been associated with this hamartoma, with basal cell carcinoma being the most frequently described malignancy. We studied a series of 155 examples of nevus sebaceus of Jadassohn with clinicopathologic correlation. Several histopathologic changes related to the age of the patients were found. In our series, we could not identify any cases of authentic basal cell carcinoma. In contrast, several examples of primitive follicular induction and of trichoblastomas were seen. Other cutaneous hamartomas, hyperplasias, and neoplasms found in our series of nevus sebaceus of Jadassohn included syringocystadenoma papilliferum, sebomatricoma, apocrine gland cyst, poroma, different histopathologic variants of warts (classic warts, tricholemmoma, and desmoplastic tricholemmoma), primitive follicular induction, and ductal induction. In our series, no examples of malignant neoplasms were identified. On the basis of these findings, the classically recommended treatment for this hamartoma, which consists of early excision to prevent the development of malignancy, seems to be inappropriate.

Update on Epidermal Nevi and Associated Syndromes

“…These authors found a much lower rate of BCC ranging from 0 % to 0.8 %. Trichoblastoma and syringocystadenoma papilliferum were the most common secondary neoplasms in these series and most frequently occurred in adulthood [13,17]. A recent review of nearly 5,000 cases of NS showed that 16 % of NS develop secondary benign tumors, whereas 8 % develop secondary malignancies, most commonly BCC, sebaceous carcinoma, SCC, and KA.…”

“…Hair follicle abnormalities are present in essentially all lesions, and typically have an embryonic or vellus appearance. Ectopic apocrine glands are frequently present [17].…”

“…However, the necessity and timing of excision is controversial. Given the recent studies reporting low rates of malignant transformation, some authors believe that early excision is not necessary [13,17]. Others believe that prophylactic excision should still be pursued because malignant transformation, although rare, can occur.…”

Nevus sebaceus of Jadassohn: an unusual case report with review of literature

“…However, this view was revised in several critical reviews stating that most of these basal cell carcinomas actually represented trichoblastomas. 6,7 Interestingly, the majority of basaloid tumors arising in nevus sebaceus are negative for PHLDA1, a follicular stem cell marker. PHLDA1 is generally positive in trichoepithelioma and trichoblastoma and negative in primary basal cell carcinoma.…”

Coexisting Basal Cell Carcinoma and Squamous Cell Carcinoma in Congenital Nevus Sebaceous

“…Malignant neoplasms, most notably basal cell carcinoma (BCC), represent less than 1% of the cutaneous neoplasms arising from NS, and frequently affect those over the age of twenty. 3,4 We report the fourth case to our knowledge of BCC and SCC arising concurrently in the same NS.A 56-year-old Hispanic female with no significant medical history presented to clinic regarding a lesion on her left cheek (Figure 1). The lesion had been present since birth but had begun to grow over the last several months.…”