Trichobezoar Without Trichotillomania—a Case Report

Edwards, Melanie; Kaz, Andrew M.; Wander, Pandora L.

doi:10.1007/s11606-021-07194-6

Cited by 1 publication

(1 citation statement)

References 25 publications

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“…As an endogenous gas, hydrogen is not only an important source of energy but also exhibits important physiological/pathological regulatory functions . As early as 1975, hydrogen was found to treat cancer, and in 2007, hydrogen was shown to be a therapeutic antioxidant that selectively reduces ischemia–reperfusion and inflammation-induced cytotoxic oxygen radicals. , Over the past decade, hydrogen has been shown to actually treat many diseases, including cancer, diabetes, stroke, atherosclerosis, Parkinson’s disease, Alzheimer’s disease, arthritis, dermatitis, colitis, hepatitis, pancreatitis, myocardial infarction, and trichotillomania . In comparison to conventional antioxidants, hydrogen can freely enter intracellular compartments and molecular clusters, and hydrogen as an antioxidant could selectively cut down the levels of toxic reactive oxygen species (ROS), for example, hydroxyl radicals and peroxynitrite, without disturbing the normal ROS signal. , Nowadays, hydrogen as a therapeutic drug has widely demonstrated its utility and safety in biomedical applications .…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Metal-Hydride-Based Disease Treatment

Li,

Cao,

Feng

et al. 2024

ACS Appl. Mater. Interfaces

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In comparison to traditional antioxidant treatment methods, the use of hydrogen to eliminate reactive oxygen species from the body has the advantages of high biological safety, strong selectivity, and high clearance rate. As an energy storage material, metal hydrides have been extensively studied and used in transporting hydrogen as clean energy, which can achieve a high hydrogen load and controlled hydrogen release. Considering the antioxidant properties of hydrogen and the delivery ability of metal hydrides, metalhydride-based disease treatment strategies have attracted widespread attention. Up to now, metal hydrides have been reported for the treatment of tumors and a range of inflammationrelated diseases. However, limited by the insufficient investment, the use of metal hydrides in disease treatment still has many shortcomings, such as low targeting efficiency, limited therapeutic activity, and complex material preparation process. Particularly, metal hydrides have been found to have a series of optical, acoustic, and catalytic properties when scaled up to the nanoscale, and these properties are also widely used to promote disease treatment effects. From this new perspective, we comprehensively summarize the very recent research progress on metal-hydride-based disease treatment in this review. Ultimately, the challenges and prospects of such a burgeoning cancer theranostics modality are outlooked to provide inspiration for the further development and clinical translation of metal hydrides.

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