Trichloroethylene: Water Contamination and Health Risk Assessment

Fan, Anna M.

doi:10.1007/978-1-4612-3770-9_2

Cited by 29 publications

(11 citation statements)

References 99 publications

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“…Trichloroethylene (TCE) is one of the most frequently detected organic contaminants found in water supplies from groundwater sources (35), is toxic to humans at high exposures, and is a known carcinogen in mice and a suspected carcinogen in humans (6). Under anaerobic conditions, TCE can be biologically reduced to form less halogenated organics (2, 24).…”

mentioning

confidence: 99%

Effects of toxicity, aeration, and reductant supply on trichloroethylene transformation by a mixed methanotrophic culture

Alvarez‐Cohen

McCarty

1991

Appl Environ Microbiol

216

165

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The trichloroethylene (TCE) transformation rate and capacity of a mixed methanotrophic culture at room temperature were measured to determine the effects of time without methane (resting), use of an alternative energy source (formate), aeration, and toxicity of TCE and its transformation products. The initial specific TCE transformation rate of resting cells was 0.6 mg of TCE per mg of cells per day, and they had a finite TCE transformation capacity of 0.036 mg of TCE per mg of cells. Formate addition resulted in increased initial

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mentioning

confidence: 99%

Effects of toxicity, aeration, and reductant supply on trichloroethylene transformation by a mixed methanotrophic culture

Alvarez‐Cohen

McCarty

1991

Appl Environ Microbiol

216

165

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“…Acute exposure to high concentrations TCE could cause headache, defatting dermatitis, lethargy, pulmonary edema, renal and hepatic damage, etc. In longterm exposure, patients experienced similar symptoms as in the acute exposure but with greater severity and persistence [2]. Risks of kidney carcinogenesis, liver carcinogenesis and non-Hodgkin lymphoma (NHL) were also enhanced with the long-term exposure [3].…”

Section: Introductionmentioning

confidence: 86%

Genetic variations underlying trichloroethylene-induced occupational medicamentosa-like dermatitis identified through massive parallel sequencing

Wu¹,

Ke²,

Xu³

et al. 2017

Biomed Genet Genomics

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Trichloroethylene (TCE) induced occupational medicamentosa-like dermatitis (OMDT) is a systemic skin disorder accompanied by liver dysfunction in workers occupationally exposed to TCE. The present study employed massive parallel sequencing by AluScan developed by us to determine genetic variations associated with sensitivity to TCE exposure. With coverage of 14.54 Mb genome regions with at least four-fold depth across two OMDT patients and two control subjects, singlenucleotide polymorphism (SNP) rs941960 located in the CCBL1 gene coding for cysteine conjugate-beta lyase, and copy number gains in CYP2C9 and CYP3A4 were identified as plausible causal factors of OMDT, all of which are components of TCE metabolic pathways. These results ascertained that variants of these genes could increase the concentrations of metabolic intermediates of TCE that may act as antigens to trigger abnormal immunological responses and give rise to liver dysfunction.

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“…It can also be found in cleaning solutions, flame retardant chemicals, and insecticides, and as a vehicle for paints, varnishes, and glues. Its release into the atmosphere by factories and into soil and water by improper waste disposal processes has been found to cause public exposures by way of air, water, and food products [52][53][54]. The Environmental Protection Agency has established recommended exposure limits for TCE; however, these levels are based on its carcinogenic properties.…”

Section: Trichlorethylenementioning

confidence: 99%

Toxic Encephalopathies

Eicher¹,

Avery²

2005

Neurologic Clinics

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Effective brain function is dependent on precise and complex interactions among neurotransmitters, hormones, enzymes, and electrolytes. Many of the chemically complex substances with which we come into contact can disrupt this intricately balanced system. Toxic substances, whether ingested, inhaled, or absorbed through the skin, may cause an encephalopathic state directly by affecting the brain itself or indirectly by compromising the brain's supportive systems. The article focuses on neurotoxins (heavy metals, solvents and vapors, pesticides, and natural neurotoxins) that directly induce an encephalopathic state.

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Trichloroethylene: Water Contamination and Health Risk Assessment

Cited by 29 publications

References 99 publications

Effects of toxicity, aeration, and reductant supply on trichloroethylene transformation by a mixed methanotrophic culture

Effects of toxicity, aeration, and reductant supply on trichloroethylene transformation by a mixed methanotrophic culture

Genetic variations underlying trichloroethylene-induced occupational medicamentosa-like dermatitis identified through massive parallel sequencing

Toxic Encephalopathies

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