Trichloroethylene neuropathy.

Mitchell, A. B.; Parsons-Smith, B. G.

doi:10.1136/bmj.1.5641.422

Cited by 44 publications

(4 citation statements)

References 13 publications

(19 reference statements)

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“…EEG abnormalities were frequent 'among the subjects, especially among those with solvent exposure. On the other hand, Mitchell and Parsons-Smith (44) stated that the EEG is usually unaffected. The EEGof a Japanese with a tr,ansverse lesion of the spinal cord after accidental exposure to trichloroethylene was reported to be normal also (50).…”

Section: Cal'bon Disulfidementioning

confidence: 99%

“…Trichloroethylene or some of its breakdown products have caused cranial polyneuropathy, most marked in the fifth cranial nerve, in workers in industry (7,44,70). Similar case reports have appeared earlier in connection with general anesthesia of trichloroethylene and soda lime in a closed circuit as cited by Buxton and Hay-10 ward (7).…”

Section: Cal'bon Disulfidementioning

confidence: 99%

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Applications of neurophysiological methods in occupational medicine. A review.

Am¹

1975

Scand J Work Environ Health

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Section: Cal'bon Disulfidementioning

confidence: 99%

Section: Cal'bon Disulfidementioning

confidence: 99%

Applications of neurophysiological methods in occupational medicine. A review.

Am¹

1975

Scand J Work Environ Health

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“…Soon after the introduction of trichloroethylene into German industry as a degreasing agent during World War I, there were reports of neurological manifestations related to exposure [Plesner, 19151. Since then, there have been current case histories on cranial nerve disturbance or fatal cases with severe histological alterations in the central nervous system after accidental overexposure or degreasing inside a tank [Mitchell and Parssons-Smith, 1969;Feldman et al, 19851. From the 1950s to the 1970s, there have been several reports on neuropsychological symptoms called neurosis or psychoorganic syndrome among industrial cohorts.…”

Section: Introductionmentioning

confidence: 99%

Solvent‐induced chronic toxic encephalopathy

Rasmussen

Jeppesen

Sabroe

1993

American J Industrial Med

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Chlorinated solvents, especially trichloroethylene, have been extensively used for metal degreasing since the beginning of this century. There have been case reports of cranial nerve damage and symptoms of acute and reversible encephalopathy. However, another issue during the last decade is the possible existence of a syndrome of chronic cerebral dysfunction. Our study deals with the risk of developing a state of psychoorganic syndrome after long-term exposure to solvents, mainly trichloroethylene. In this historical cohort study, 96 metal degreasers participated in a clinical medical and psychological examination. The risk of developing psychoorganic syndrome was proportional to the exposure duration, to increasing age, and to decreasing primary intellectual level. Using logistic regression analysis, there was a significantly increased risk of developing psychoorganic syndrome from solvent exposure. There was an odds ratio of 5.6 (0.93-34.3) for psychoorganic syndrome in the medium-exposed group. In the most highly exposed group, with a mean full-time exposure duration of 11 years, there was a significantly increased risk of psychoorganic syndrome, the adjusted odds ratio was 11.2 (1.9-66.6). None of four other potential confounders (arteriosclerotic disease, neurologic/psychiatric disease, alcohol abuse, and current solvent exposure) had any significant associations to psychoorganic syndrome.

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“…It has been reported in association with multiple sclerosis (McAlpine, Lumsden, and Acheson, 1965), syphilis (Ornsteen, 1931), arachnoiditis (Hughes, 1958), sarcoidosis (Jefferson, 1957), connective tissue diseases (Ashworth and Tait, 1971), and after exposure to toxic chemicals (Collard and Hargreaves, 1947;Mitchell and Parsons-Smith, 1969). Trauma and dental abnormalities (Collard and Hargreaves, 1947) have caused the symptom and the relationship to space occupying lesions including primary nasopharyngeal cancer (New, 1922) and carotid aneurysm (Goldstein, Gibilisco, and Rushton, 1963) is well recognized.…”

mentioning

confidence: 99%

The numb chin in breast cancer

Horton

Means

Cunningham

et al. 1973

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY Numbness of the chin, an uncommon neurological symptom, was observed in 15 patients with cancer. Thirteen had breast cancer. This symptom usually heralded progressive involvement of the cranial nerves or cerebrum and denoted a poor prognosis in patients with a short 'tumourfree interval'. The pathogenesis is commonly related to dural involvement of the Vth cranial nerve at the base of the brain, although metastasis to the mandible might sometimes be implicated. The reason for the peculiar predilection for the mandibular branch of the trigeminal nerve to be affected by breast cancer is not known.

show abstract

Trichloroethylene neuropathy.

Cited by 44 publications

References 13 publications

Applications of neurophysiological methods in occupational medicine. A review.

Applications of neurophysiological methods in occupational medicine. A review.

Solvent‐induced chronic toxic encephalopathy

The numb chin in breast cancer

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