1981
DOI: 10.1016/0300-483x(81)90121-9
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Trichloroethylene: Effects on body and organ weights in mice, rats and gerbils

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1983
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Cited by 26 publications
(9 citation statements)
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“…CNS toxicity in animals is characterized by ataxia, lethargy, hindlimb paralysis, and convulsions; irreversible CNS lesions with accompanying behavioral changes have been induced in several species by chronic exposure to TCE (Kjellstrand, 1980(Kjellstrand, , 1981a. Arito and coworkers (1993) reported abnormal electroencephalogram activity, incapacitation of postural maintenance, decreased waking time, lowered heart rate, and increased numbers of bradyarrhythmic episodes in electrode-implanted and freely moving rats exposed to 3,000 and 6,000 ppm TCE.…”
mentioning
confidence: 99%
“…CNS toxicity in animals is characterized by ataxia, lethargy, hindlimb paralysis, and convulsions; irreversible CNS lesions with accompanying behavioral changes have been induced in several species by chronic exposure to TCE (Kjellstrand, 1980(Kjellstrand, , 1981a. Arito and coworkers (1993) reported abnormal electroencephalogram activity, incapacitation of postural maintenance, decreased waking time, lowered heart rate, and increased numbers of bradyarrhythmic episodes in electrode-implanted and freely moving rats exposed to 3,000 and 6,000 ppm TCE.…”
mentioning
confidence: 99%
“…We have previously studied different effects of TCE exposure in mice Kjellstrand et al 1981Kjellstrand et al & 1983. The effects of PCE exposure were basically the same: increased plasma BuChE activity, increased liver weight and decreased body weight gain.…”
Section: Discussionmentioning
confidence: 99%
“…We have found that liver weight and plasma butyrylcholinesterase (BuChE, EC 3. 1.1.8) are sensitive and reliable measures of different biological effects of TCE in mice ; Kjellstrand et al 1981Kjellstrand et al & 1983. In male mice, BuChE activity increases after TCE exposure, whereas liver weight increase in both sexes.…”
mentioning
confidence: 99%
“…No gross pathological liver effects were observable in several species (rats, guinea pigs, rabbits, dogs) exposed to 730 ppm (8 hr/day, 5 days/week, for 6 weeks) (87). Dose-related (37-300 ppm) increases in LW/BW in mice were reported without more direct measures of liver toxicity (89)(90)(91)(92) Quantitative Dose-Response Analysis Each study previously identified as a potential critical study was evaluated using one or more methods for developing toxicity values (6,1 1). These methods ranged from the default approach used in the absence of any information except a LOAEL to approaches that incorporate mode-of-action and dosimetry data to assist in extrapolating between exposure regimens, dose levels, study durations, and species.…”
Section: Selection Ofinhalation Studiesmentioning
confidence: 96%