Trichinella spiralis: Inhibition of sheep hemagglutinins in mice

Faubert, G M; Tanner, C. E.

doi:10.1016/0014-4894(71)90077-4

Cited by 72 publications

(20 citation statements)

References 8 publications

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“…These effects were attributed to the presence of the regulatory cytokine IL-10. Immune evasion mechanisms used by nematodes to affect host immunity are not uncommon (4) and have been shown in studies with T. spiralis, Heligmosomoides polygyrus (3,13,30,35,37,53), N. brasiliensis (27), and A. suum (10,33,54).…”

Section: Discussionmentioning

confidence: 99%

Infection withSyphacia obvelata(Pinworm) Induces Protective Th2 Immune Responses and Influences Ovalbumin-Induced Allergic Reactions

et al. 2006

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Infections with pinworms are common in rodent animal facilities. In this study, we show the consequence of an outbreak in a transgenic barrier facility of infection by Syphacia obvelata, a murine pinworm gastrointestinal nematode. Immune responses were defined in experimental infection studies with BALB/c mice. Infection with S. obvelata induced a transient Th2-type immune response with elevated interleukin 4 (IL-4), IL-5, and IL-13 cytokine production and parasite-specific immunoglobulin G1 (IgG1). In contrast, BALB/c mice deficient in IL-13, IL-4/13, or the IL-4 receptor alpha chain showed chronic disease, with a >100-fold higher parasite burden, increased gamma interferon production, parasite-specific IgG2b, and a default Th2 response. Interestingly, infected IL-4 ؊/؊ BALB/c mice showed only slightly elevated parasite burdens compared to the control mice, suggesting that IL-13 plays the dominant role in the control of S. obvelata. The influence that pinworm infection has on the allergic response to a dietary antigen was found to be important. Helminth-infected mice immunized against ovalbumin (Ova) elicited more severe anaphylactic shock with reduced Ova-specific IL-4 and IL-5 than did noninfected controls, demonstrating that S. obvelata infection is able to influence nonrelated laboratory experiments. The latter outcome highlights the importance of maintaining mice for use as experimental models under pinworm-free conditions.

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Section: Discussionmentioning

confidence: 99%

Infection withSyphacia obvelata(Pinworm) Induces Protective Th2 Immune Responses and Influences Ovalbumin-Induced Allergic Reactions

et al. 2006

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“…Infections with metazoan parasites have been reported to potentiate or depress the humoral response to heterologous antigens [1,3,4,6,14]. In the case of Trichinella spiralis, infection with this nematode results in a marked effect on both specific and non-specific responses to particulate substances.…”

Section: Introductionmentioning

confidence: 99%

Effect of Trichinella spiralis Infection on the Cell-Mediated Immune Response to BCG

Molinari¹,

Cypess²,

Ebersole³

1974

Int Arch Allergy Immunol

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Mice infected with Trichinella spiralis have shown resistance to both intravenous and intraperitoneal infection with Listeria monocytogenes. Since protection against L. monocytogenes is mediated by cellular immunity, the effect of infection with T. spiralis on the immune response to BCG was investigated. ICR/CD₁ mice were infected with 200 T. spiralis at 14, 56, 98 and 112 days preceding intravenous administration of 4 × 10⁶ viable BCG. Groups were tested for delayed hypersensitive foot pad responses 28 days following BCG inoculation. All mice receiving T. spiralis and BCG exhibited a marked potentiation of the 24-hour foot pad response to Old Tuberculin over that shown by the appropriate controls.

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“…Infection with this nematode, treatment with Trichinella-immune serum, or parasitic extracts resulted in suppression of both anti body formation for 7-56 days posthelminth infection and spleen plaque-forming cells to sheep red blood cells for 14-28 days after infection [6][7][8]11], An increased suscepti bility to Japanese B encephalitis virus. which was maximum 7 days after nematode administration, was also noted in mice in fected with this parasite [2,11,12].…”

Section: Introductionmentioning

confidence: 99%

Effect of Trichinella spiralis Infection on Delayed Hypersensitivity to Heterologous Antigens

Blackwood¹,

Molinari²

1978

Int Arch Allergy Immunol

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Studies were initiated to determine the effects of the different phases of the nematode life cycle on the delayed-type hypersensitivity (DTH) capabilities of the host. Mice were injected intraperitoneally with 4 × 10⁶ viable or heat-killed BCG at 0, 3, 7, 14 and 28 days after oral infection with 200 Trichinella spiralis larvae. Groups were tested for DTH 28 days after BCG inoculation by the footpad swelling assay. Infection with T. spiralis was found to suppress the response in mice administered viable BCG 0 or 3 days later. Mice injected with viable bacteria 7 days after T. spiralis regained the ability to develop in vivo DTH reactions against old tuberculin. Groups administered viable BCG 14 and 28 days after nematode infection yielded potentiated DTH responses, when compared with control mice. Animals infected with T. spiralis and later injected with heat-killed BCG required a longer interval to develop specific immunopotentiation. Maximum immunopotentiation seemed to be related to the presence of larvae in muscle tissue (28 days). These findings suggest that the effect of T. spiralis on the immune capabilities of the host is dependent on the different anatomical locations of the parasite.

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Trichinella spiralis: Inhibition of sheep hemagglutinins in mice

Cited by 72 publications

References 8 publications

Infection withSyphacia obvelata(Pinworm) Induces Protective Th2 Immune Responses and Influences Ovalbumin-Induced Allergic Reactions

Infection withSyphacia obvelata(Pinworm) Induces Protective Th2 Immune Responses and Influences Ovalbumin-Induced Allergic Reactions

Effect of <i>Trichinella spirali</i><i>s</i> Infection on the Cell-Mediated Immune Response to BCG

Effect of <i>Trichinella spiralis</i> Infection on Delayed Hypersensitivity to Heterologous Antigens

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