Trichinella spiralis infection reduces tumor growth and metastasis of B16-F10 melanoma cells

Kang, Yun‐Jeong; Jo, Jin-Ok; Cho, Minkyoung; Yu, Hak Sun; Leem, Sun‐Hee; Song, Kyoung Seob; Ock, Mee Sun; Cha, Hee‐Jae

doi:10.1016/j.vetpar.2013.02.021

Cited by 40 publications

(41 citation statements)

References 24 publications

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“…Also, the authors demonstrated strong antiproliferative and high proapoptotic influence of T. spiralis antigens on two different cell lines in vitro (K562 and H7402). Even in case of very aggressive tumor cell lines like B16 melanoma, T. spiralis infection succeeds to reduce not only the growth but also malignant cell dissemination [149]. In line with these findings our investigation confirmed the capacity of T. spiralis infection to restrain B16 melanoma development in C57Bl/6 mice [150].…”

Section: T Spiralis Immunomodulation Of Autoimmunity Allergy Ansupporting

confidence: 84%

Secretory Products ofTrichinella spiralisMuscle Larvae and Immunomodulation: Implication for Autoimmune Diseases, Allergies, and Malignancies

Sofronić-Milosavljević

Ilić

Pinelli

et al. 2015

Journal of Immunology Research

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Trichinella spiralis has the unique ability to make itself “at home” by creating and hiding in a new type of cell in the host body that is the nurse cell. From this immunologically privileged place, the parasite orchestrates a long-lasting molecular cross talk with the host through muscle larvae excretory-secretory products (ES L1). Those products can successfully modulate parasite-specific immune responses as well as responses to unrelated antigens (either self or nonself in origin), providing an anti-inflammatory milieu and maintaining homeostasis. It is clear, based on the findings from animal model studies, that T. spiralis and its products induce an immunomodulatory network (which encompasses Th2- and Treg-type responses) that may allow the host to deal with various hyperimmune-associated disorders as well as tumor growth, although the latter still remains unclear. This review focuses on studies of the molecules released by T. spiralis, their interaction with pattern recognition receptors on antigen presenting cells, and subsequently provoked responses. This paper also addresses the immunomodulatory properties of ES L1 molecules and how the induced immunomodulation influences the course of different experimental inflammatory and malignant diseases.

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Section: T Spiralis Immunomodulation Of Autoimmunity Allergy Ansupporting

confidence: 84%

Secretory Products ofTrichinella spiralisMuscle Larvae and Immunomodulation: Implication for Autoimmune Diseases, Allergies, and Malignancies

Sofronić-Milosavljević

Ilić

Pinelli

et al. 2015

Journal of Immunology Research

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“…The impact of T. spiralis infection, as well as crude antigens derived from this parasite, on the growth of solid tumours in vivo or malignant cell lines in vitro has been shown by a limited number of studies [10, 19]. Studies of anti-tumour mechanisms used by Trichinella are even more modest and cover only a small segment of immune response (the role of chemokines, increasingly expressed due to infection, in tumour regression) [15]. …”

Section: Discussionmentioning

confidence: 99%

“…Among the other functions, products of helminth parasites have the capacity to modify signal transduction, resulting either in the host cell proliferation or cell death [12–14]. These kinds of modifications are observed in cancer cells in cases when tumours and parasite infection coincide or even more when the infection precedes tumour induction [15]. Antitumor effects have been described for infections with some parasites, like Toxoplasma gondii [16], Trypanosoma cruzi [17], and Plasmodium yoelli [18].…”

Section: Introductionmentioning

confidence: 99%

“…[11] constructed a T7 phage display cDNA library of T. spiralis and showed that one recombinant protein, A200711, has a pro-apoptotic effect on the H7402 cell line, and hence it was proposed as a therapeutic agent in hepatocellular carcinoma treatment. Recently, it has been demonstrated on an in vivo model system of B16-F10 melanoma in mice that T. spiralis infection is a potent reducer of tumour growth and metastasis [15]. …”

Section: Introductionmentioning

confidence: 99%

“…Investigations of substances that can affect the apoptotic process in melanoma would be a valuable contribution to finding new therapeutic approaches for this disease. From the modest level of data available in the field it appears that all three stages of T. spiralis life cycle contain components that are able to control malignancy [10, 15, 19]. On the other hand, it was shown that this parasite could tame autoimmune disease [6], implying the involvement of completely different mechanisms that create a tolerogenic environment [25, 26].…”

Section: Introductionmentioning

confidence: 99%

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Experimental immunology Necrosis and apoptosis in Trichinella spiralis -mediated tumour reduction

Vasilev¹,

Ilić²,

Gruden-Movsesijan³

et al. 2015

cejoi

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It is known that infection with different pathogens, including helminths, can alter the progression of malignant or other diseases. We studied the effect of chronic Trichinella spiralis infection or muscle larvae excretory-secretory (ES L1) antigens on the malignant tumour growth in the mouse melanoma model system in vivo and in vitro. Our results confirmed that chronic infection with T. spiralis possesses the capacity to slow down the progression of tumour growth, resulting in an impressive reduction in tumour size. We found that the phenomenon could, at least partially, be related to a lower level of tumour necrosis compared to necrosis present in control animals with progressive malignancy course. An increased apoptotic potential among the low percentage of cells within the total tumour cell number in vivo was also observed. ES L1 antigen, as a parasitic product that is released during the chronic phase of infection, reduced the survival and slightly, but significantly increased the apoptosis level of melanoma cells in vitro. Our results imply that powerful Trichinella anti-malignance capacity does not rely only on necrosis and apoptosis but other mechanisms through which infection or parasite products manipulate the tumor establishment and expansion should be considered.

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Antitumor Effect Induced by Protozoa and Helminth Infections: Current Trends and Future Perspectives

García López,

González Cerón,

Torrel Pajares

2024

Pathogens Associated With the Development of Cancer in Humans

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Trichinella spiralis infection reduces tumor growth and metastasis of B16-F10 melanoma cells

Cited by 40 publications

References 24 publications

Secretory Products ofTrichinella spiralisMuscle Larvae and Immunomodulation: Implication for Autoimmune Diseases, Allergies, and Malignancies

Secretory Products ofTrichinella spiralisMuscle Larvae and Immunomodulation: Implication for Autoimmune Diseases, Allergies, and Malignancies

Experimental immunology Necrosis and apoptosis in Trichinella spiralis -mediated tumour reduction

Antitumor Effect Induced by Protozoa and Helminth Infections: Current Trends and Future Perspectives

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