Trichinella spiralis infection ameliorated diet-induced obesity model in mice

Kang, Shin Ae; Choi, Jun Ho; Baek, Kyung‐Wan; Lee, Dain; Jeong, Mi Jin; Yu, Hak Sun

doi:10.1016/j.ijpara.2020.07.012

Cited by 16 publications

(14 citation statements)

References 53 publications

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“…T. spiralis infection attenuated the hepatic histopathological changes caused by HFD such as hepatocellular vacuolation and increased frequency of lipid droplets. Moreover, the adipocyte size, the gonadal white adipose tissue, was decreased significantly by T. spiralis infection as compared to non-infected mice on HFD ( Kang et al, 2021 ). Interestingly, they reported that the elimination of T. spiralis (by anthelminthics 21 days post infection) retained the anti-obesity effects.…”

Section: Trichinella -Derived Molecules: a Panacea For Moder...mentioning

confidence: 99%

Trichinella-induced immunomodulation: Another tale of helminth success

Bruschi

Ashour

Othman

2022

Food and Waterborne Parasitology

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Section: Trichinella -Derived Molecules: a Panacea For Moder...mentioning

confidence: 99%

Trichinella-induced immunomodulation: Another tale of helminth success

Bruschi

Ashour

Othman

2022

Food and Waterborne Parasitology

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“…The SCFA receptor FFAR3 in the host was required for the induction of anti-inflammatory pathways and the observed protective effect [ 74 ]. Also, the enhanced ability of H. polygyrus -modified microbiota to produce SCFA underlies its ability to induce resistance to obesity and glucose intolerance [ 75 ], which seems to be the same for T. spiralis [ 76 ]. Other studies suggest that N. brasiliensis and Strongyloides venezuelensis improve insulin sensitivity in mice, likely through their impact on the microbiota [ 77 , 78 ].…”

Section: Biological and Clinical Consequences Of The Modifications Ex...mentioning

confidence: 99%

“…Other studies suggest that N. brasiliensis and Strongyloides venezuelensis improve insulin sensitivity in mice, likely through their impact on the microbiota [ 77 , 78 ]. The alteration of the gut microbiota exerted by H. polygyrus —and probably other helminths as well—is determined by a type 2 immune response involving M2 macrophages [ 75 , 76 , 77 ].…”

Section: Biological and Clinical Consequences Of The Modifications Ex...mentioning

confidence: 99%

Helminths and Bacterial Microbiota: The Interactions of Two of Humans’ “Old Friends”

Llinás-Caballero

Caraballo

2022

IJMS

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Humans have coexisted with helminths and bacteria for the entire existence of our species. Nowadays, helminth infections affect more than 1.9 billion people worldwide, especially in underdeveloped regions that lack optimal sanitary conditions. In addition, commensal microorganisms inhabit several compartments of humans, including the gastrointestinal tract, constituting what we know as the microbiota. Helminths and bacterial microbiota can interact in various ways. In this review, the interactions between helminths and commensal bacteria are analyzed in both animal models and humans. In developing countries, the gut microbiota exhibits high diversity, which could be linked to the high burden of helminthiasis in these areas. In fact, several studies show that helminth infections are associated with an increased gut microbiota diversity and changes in its composition. Interestingly, these changes can modify the risk for some diseases, such as asthma, colitis, viral infections, and metabolic conditions. Besides, the microbiota is necessary for the establishment of some helminth infections and can also influence the evolution of these diseases. Specific bacterial taxa can contribute to the resistance or susceptibility to certain helminths. The mechanisms underlying helminth–microbiota interactions are not completely understood. More research is necessary to address this and other unmet needs, especially considering that available studies are heterogeneous and sometimes yield conflicting results

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“…In this study, TsAg markedly prevented hepatic macrophage infiltration, reduced M1 macrophages, and increased M2 macrophages, consistent with previous research in HFD-induced mice infected with T. spiralis . Collectively, these findings indicated that TsAg can alleviate NAFLD by regulating macrophage polarization for suppressing proinflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

Effect of Trichinella spiralis-Derived Antigens on Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in Mice

Yang,

He,

Yang

et al. 2024

ACS Pharmacol. Transl. Sci.

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Nonalcoholic fatty liver disease (NAFLD) is a liver disease characterized by hepatic steatosis, inflammation, and fibrosis, as well as gut dysbiosis. No approved effective therapeutic medicine is available to date for NAFLD. Helminth therapy is believed to be a novel direction and therapeutic strategy for NAFLD. Our previous study showed that Trichinella spiralis-derived antigens (TsAg) had the potential for partially alleviating obesity via regulating gut microbiota. However, the effect of TsAg on NAFLD remains unclear. In this study, high-fat diet (HFD)-induced model mice were treated with TsAg and microbiota transplantation experiments, and alterations in the pathogenesis of nonalcoholic liver disease were assessed. The results showed that TsAg markedly reduced hepatic steatosis, improved insulin resistance, and regulated the abnormal expression of hepatic lipid-related genes. Of note, TsAg ameliorated hepatic inflammation by decreasing proinflammatory TNF-α and IL-1β, suppressing hepatic macrophage infiltration, as well as promoting M2 macrophage polarization. Moreover, TsAg reversed gut dysbiosis, as especially indicated by an increase in beneficial bacteria (e.g., Akkermansiaceae and Rikenellaceae). Furthermore, our study found that TsAg reduced LPS hepatic translocation and hepatic TLR4/NF-κB signaling, which further contributed to inhibiting hepatic inflammation. In addition, TsAg inhibited hepatic oxidative stress involving Nrf2/NQO-1 signaling. Microbiota transplantation showed that TsAg-altered microbiota is sufficient to confer protection against NAFLD in HFDinduced mice. Overall, these findings suggest that TsAg involving gut−liver axis and Nrf2/NQO-1 signaling is a novel promising candidate for NAFLD treatment. TsAg restores intestinal microbiota and intestinal barrier to inhibit bacteria and LPS translocation into the liver, contributing to reduce inflammation, oxidative stress, and hepatic steatosis in the liver of NAFLD mice. The effects were attributed to, at least in part, the inactivation of NF-κB pathway and the activation of Nrf-2/NQO-1 pathway. This study provides new insights for understanding immune modulation by T. spiralis-derived products as well as the potential application of TsAg as a modality for NAFLD.

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Trichinella spiralis infection ameliorated diet-induced obesity model in mice

Cited by 16 publications

References 53 publications

Trichinella-induced immunomodulation: Another tale of helminth success

Trichinella-induced immunomodulation: Another tale of helminth success

Helminths and Bacterial Microbiota: The Interactions of Two of Humans’ “Old Friends”

Effect of Trichinella spiralis-Derived Antigens on Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in Mice

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