Trichilia catigua : therapeutic and cosmetic values

Longhini, Renata; Lonni, Audrey Alesandra Stinghen Garcia; Sereia, Ana Luiza; Krzyzaniak, Letícia Maria; Lopes, Gisely Cristiny; Mello, João Carlos Palazzo de

doi:10.1016/j.bjp.2016.10.005

Cited by 14 publications

(12 citation statements)

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“…Trichilia catigua (Meliaceae) is a species of South America, known as catuaba, tatuaba and catiguá, and used in folk medicine as a tonic for the treatment of fatigue, stress, impotence and memory deficit [ 1 , 4 – 6 ]. These popular uses are typical of an adaptogen, which is supposed to decrease the consequences of stress and improve physical and cognitive performances both in healthy and ill patients [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…The most common popular form of preparation is as “garrafada” (the maceration of the barks in alcoholic drinks, usually 38–48% alcohol). Several other species are also known as catuaba and are used for similar purposes, but most of the available commercial products use barks of T. catigua [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Flavonoids, tannins, alkaloids, saponins, among other phytochemical classes were identified in the barks of T. catigua [ 4 ]. The bark contains high concentrations of polyphenols including flavan-3-ols (procyanidin B2, epicatechin, catechin), flavalignans (cinchonains Ia, Ib, IIa, IIb) and phenylpropanoid derivatives (chlorogenic acid) [ 7 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Pre-clinical studies with T. catigua extracts have shown many pharmacological properties, such as anti-inflammatory [ 11 ], antinociceptive [ 12 ], antidepressant [ 5 , 13 , 14 ], pro-memory [ 5 ] and neuroprotective against ischemia and oxidative stress [ 6 , 15 , 16 ]. The antinociceptive and antidepressant effects are attributed mainly to dopaminergic action [ 12 , 13 ] and were also described for a commercial preparation containing T. catigua , Paullinia cupana , Ptychopetalum olacoides and Zingiber officinale Roscoe [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba)

Martins¹,

Brito²,

Araújo³

et al. 2018

BMC Complement Altern Med

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BackgroundTrichilia catigua A. Juss. (Meliaceae) is a species known as catuaba and used in folk medicine for the treatment of fatigue, stress, impotence and memory deficit. The main phytochemical compounds identified in the barks of T. catigua are flavalignans, flavan-3-ols and flavonoids which are associated with its antioxidant activity. Pre-clinical studies with T. catigua extracts have identified many pharmacological properties, such as anti-inflammatory, antidepressant, antinociceptive, pro-memory and neuroprotective against ischemia and oxidative stress. This study was designed in order to compare the chemical composition and in vitro antioxidant and anticholinesterase activity of four different polarity extracts and selected the one most active for in vivo studies in rodent models of stress, fatigue and memory.MethodsHexane, chloroform, hydroalcoholic and aqueous extracts from bark of Trichilia catigua were analyzed by RPHPLC-DAD-ESI-MS/MS. Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay and acetylcholinesterase inhibition by Ellman’s modified method. In vivo studies (stress, fatigue and memory) were carried out with adult male mice and rats treated with hydroalcoholic extract in doses of 25–300 mg/kg (p.o.).ResultsWe confirmed the presence of cinchonain IIa, Ia and Ib, as main constituents in the four extracts, while procyanidins were detected only in hydroalcoholic extract. Antioxidant and anticholinesterase activity were observed for all extracts, with most potent activity found on the hydroalcoholic extract (EC50 = 43 μg/mL and IC50 = 142 μg/mL for DPPH scavenger and acetylcholinesterase inhibition, respectively). The treatment of laboratory animals with hydroalcoholic extract did not protect rats from cold immobilization stress and did not prevent the scopolamine-induced amnesia in mice. However, the treatment of mice with the hydroalcoholic extract partially reduced the fatigue induced by treadmill, since the highest dose increased the spontaneous locomotor activity and reduced the deficit on grip strength after the forced exercise (p < 0.05), in some observation times.ConclusionsThese data suggest the hydroalcoholic extract as the most suitable for plant extraction and partially support the folk use of T. catigua as antifatigue drug.Graphical abstract.Trichilia catigua hydroalcoholic extract exhibits antioxidant and anticholinesterase activity in vitro and reduces the fatigue induced by forced exercise.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2222-9) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba)

Martins¹,

Brito²,

Araújo³

et al. 2018

BMC Complement Altern Med

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“…Bark, leaves, fruits and roots have been used to treat a broad variety of disorders, including stomach, diarrhea, dermatitis, taeniasis, pneumonia, lung, kidney and liver pains, as well to heal wounds [ 11 ]. The biological and pharmacological properties of Trichilia species have been reviewed by Longhini et al [ 1 ], Garg [ 12 ], Curcino Vieira et al [ 2 ] and Komane et al [ 13 ]. More recently, limonoids have been studied for their effects on inflammatory disorders [ 14 , 15 ] and as cytotoxic agents [ 9 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Trichilones A–E: New Limonoids from Trichilia adolfi

et al. 2021

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In addition to the trichilianones A–D recently reported from Trichilia adolfi, a continuing investigation of the chemical constituents of the ethanol extract of the bark of this medicinal plant yielded the five new limonoids 1–5. They are characterized by having four fused rings and are new examples of prieurianin-type limonoids, having a ε-lactone which in 4 and 5 is α, β- unsaturated. The structures of the isolated metabolites were determined by high field NMR spectroscopy and HR mass spectrometry. The new metabolites were shown to have the ε-lactone fused with a tetrahydrofuran ring which is connected to an oxidized hexane ring joined with a cyclo-pentanone having a 3-furanyl substituent. As the crude extract possesses antileishmanial activity, the compounds were assayed for cytotoxic and antiparasitic activities in vitro in murine macrophage cells (raw 264.7 cells) and in Leishmania amazoniensis as well as L. braziliensis promastigotes. Metabolites 1–3 and 5 showed moderate cytotoxicity (between 30–94 µg/mL) but are not responsible for the antileishmanial effect of the extract.

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