Trichilia catigua and Turnera diffusa extracts: In vitro inhibition of tyrosinase, antiglycation activity and effects on enzymes and pathways engaged in the neuroinflammatory process

UHPLC-MS Characterization and Biological Insights of Different Solvent Extracts of Two Achillea Species (A. aleppica and A. santolinoides) from Turkey

“…Tyrosinase is main enzyme in the synthesis of melanin and thus its inhibition could be valuable for controlling hyperpigmentation problems [ 24 ]. In the light of these facts, the discovery of new and effective enzyme inhibitors, especially from natural sources, is gaining great interest in the scientific platform [ 25 , 26 , 27 ].…”

Cytotoxicity of areca catechu nut (betel nut) in BV-2 microglial cells and impact of areca alkaloids

“…Materials and Methods: Scavenging activity was evaluated upon nitric oxide and superoxide radicals in cell-free systems, as described in [2]. The impact upon the mitochondrial activity in BV-2 cells was investigated by the MTT assay, followed by the assessment of the effects on nitric oxide levels [3]. Results: Both arecoline and guvacine proved to be inactive on the scavenging ability upon nitric oxide at the full range of concentrations being tested (3.125-100 μM), while arecaidine was found to increase the levels of the radical at concentrations higher than 25 μM.…”

Flavonoids and intestinal microbes interact to alleviate depression

“…The structural and functional integrity of the hippocampus is closely related to human learning and memory, and it plays an important role in antidepressant disorders in particular. 74 Studies have shown that Forkhead box transcription factor G1 (FoxG1) plays an important role in brain development, regulating neural development during the embryonic period, and is consistently expressed. FoxG1 can protect the nervous system by regulating adult hippocampal neurogenesis in mice to protect the nervous system.…”

“…Both extracts (IC 50 = 358.84 ± 19.05 μg mL −1 and 56.25 ± 14.53 μg mL −1 respectively) protected against the presence of high concentrations of polyunsaturated fatty acids in human brain by inhibiting lipid peroxidation induced by the iron ion–ascorbic acid system, preventing the production of highly reactive substances due to peroxidation of polyunsaturated fatty acids leading to intracellular oxidative stress and damage to cell structure. The structural and functional integrity of the hippocampus is closely related to human learning and memory, and it plays an important role in antidepressant disorders in particular 74 . Studies have shown that Forkhead box transcription factor G1 (FoxG1) plays an important role in brain development, regulating neural development during the embryonic period, and is consistently expressed.…”