Trichilemmal pilar tumors

Janitz, Joachim; Wiedersberg, H

doi:10.1002/1097-0142(19800401)45:7<1594::aid-cncr2820450713>3.0.co;2-o

Cited by 41 publications

(27 citation statements)

References 13 publications

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“…A large number of cutaneous tumours show differentiation towards, or are derived from, the hair follicle apparatus (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Discussionsupporting

confidence: 94%

“…Trichilemmal cyst is the most common of these and demonstrates a pattern of keratinisation common to all of these tumours, known as trichilemmal keratinisation (5). In trichilemmal cysts, peripheral cells are stratified and rest on a thickened base membrane.…”

Section: Discussionmentioning

confidence: 98%

“…They are less common, but otherwise similar in clinical presentation, to epidermal cysts (5). The exact origin of these two lesions is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The tumour may become very large size and frequently ulcerates. These lesions tend to recur after surgical removal (2)(3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

“…For all these lesions, surgery is the treatment of choice, but this has to be adapted to the exact histological findings (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). In simple epidermal and benign trichilemmal cysts, enucleation is curative, although in proliferating trichilemmal cysts recurrences may be observed after surgical enucleation of the lesion, probably due to microscopic observation that strands and cords of cells may extend beyond the main tumour mass (as evaluated macroscopically) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Cysts: a Plea for Systematic Analysis

Vandeweyer¹,

Renard

2003

Acta Chirurgica Belgica

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So-called cutaneous cysts are extremely frequent tumours that could need surgical attention. Most of the time, due to their quite pathognomonic clinical presentation and indolent course, they are simply enucleated. Often, the clinical diagnosis is easily confirmed at surgery by the typical appearance of a cystic formation filled with a creamy fluid. It is frequent for such "typical" lesions to escape histological investigation following removal. However, some mimicking lesions could also be found as "cutaneous cysts" and have quite different prognoses. This paper present five patients with such lesions, three basal cell carcinomas, one benign proliferating trichilemmal cyst and a malignant proliferating trichilemmal cyst. None of the lesions was clinically distinguishable from a classical epidermis cyst.

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“…A large number of cutaneous tumours show differentiation towards, or are derived from, the hair follicle apparatus (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 98%

“…They are less common, but otherwise similar in clinical presentation, to epidermal cysts (5). The exact origin of these two lesions is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The tumour may become very large size and frequently ulcerates. These lesions tend to recur after surgical removal (2)(3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Cutaneous Cysts: a Plea for Systematic Analysis

Vandeweyer¹,

Renard

2003

Acta Chirurgica Belgica

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Enlarging, Painful Scalp Nodule

Carlin¹,

Bailin²,

Bergfeld³

1988

Arch Dermatol

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Proliferating trichilemmal cyst: A simulant of squamous cell carcinoma

Brownstein

Arluk

1981

Cancer

160

157

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Comparison of 50 proliferating trichilemmal cysts with 50 "ordinary" trichilemmal cysts indicated that both types almost invariably occurred on the scalps of women, were diagnosed clinically as cysts, followed a benign course, and featured trichilemmal keratinization. A spectrum was observed from trichilemmal cyst with minimal hyperplasia, to full-blown proliferating trichilemmal cyst. Occasionally, patients had ordinary trichilemmal cysts on their scalps associated with a proliferating trichilemmal cyst. In addition to trichilemmal keratini-zation, which is characteristic of the follicular isthmus, proliferating trichilemmal cysts showed a wider range of differentiation, including features of the follicular infundibulum, the lower nonkeratinizing portion of the follicular outer root sheath, and sebaceous cells. Intense inflammatory infiltrate and cellular atypia, sometimes of significant proportions, were also seen in proliferating trichilemmal cysts. It is concluded that trauma and inflammation may induce a trichilemmal cyst to proliferate and show a broader spectrum of pilosebaceous differentiation and cellular atypia of pseudocarcinomatous proportions, while maintaining its benign biologic behavior. Cancer 481207-1214,1981. HERE IS A PECULIAR benign cutaneous growth that T usually resembles a cyst clinically, but is often histologically misinterpreted as squamous cell carcino-ma. Our purpose here is to analyze the clinical and his-tologic features of a large series of proliferating trichilemmal cysts. Evidence is presented on the pathogenetic relationship between proliferating and ordinary trichilemmal cysts. Emphasis is placed on the wide range of pilosebaceous differentiation and striking cellular dysplasia encountered in proliferating cysts, compared with the restricted pattern of ordinary trichilemmal cysts. Material and Methods Fifty proliferating trichilemmal cysts were collected during the past nine years. Minimal clinical data required for inclusion in this study were the sex and age of the patient and the anatomic site of the growth. Histologic sections were reviewed in all cases. For comparative purposes, 50 uncomplicated trichilemmal cysts were studied. Clinical Features Among the 50 patients with trichilemmal cysts, 84% were women; 90% of the lesions were on the scalp (Fig. l), two were on the back, and one each on the forehead (Fig. 2), wrist, and chest (Fig. 3). The age range was 27-83 (median 59) years. One patient was in the third, 2 in the fourth, 9 in the fifth, 14 in the sixth, 14 in the seventh, 6 in the eighth, and 4 in the ninth decade. The duration ranged from one-half to over 20 (median 2) years. Sometimes, a cystic lesion had been present for years, then slowly enlarged. In 94%, the clinical diagnosis was "sebaceous," pilar, trichilem-mal, or epidermoid cyst; in two patients it was squam-ous cell carcinoma and in one, dermatofibroma. For about 50% of the patients, there was intermittent discharge or inflammation; several growths were eroded or ulcerated. Occasionally there was' bleed...

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Trichilemmal pilar tumors

Cited by 41 publications

References 13 publications

Cutaneous Cysts: a Plea for Systematic Analysis

Cutaneous Cysts: a Plea for Systematic Analysis

Enlarging, Painful Scalp Nodule

Proliferating trichilemmal cyst: A simulant of squamous cell carcinoma

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