Trichiconlides C F, four new limonoids with 1,2-seco phragmalin-type carbon skeleton from the fruits of Trichilia connaroides

An, Faliang; Sun, Dongmei; Wang, Xiao-Bing; Yang, Lei; Yin, Yong; Luo, Jun

doi:10.1016/j.fitote.2017.12.023

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…The distribution of phragmalin-class limonoids ( C295–C669 ) in plants is similar to mexicanolide-class and is almost concomitant, except that phragmalins are mainly present in the genus Chukrasia (138, 37.4%, accounts for 93% of limonoids from the genus Chukrasia ). 69,262,267–286 The genera Xylocarpus (59, 16.0%), 36,55,56,58,72,83,128,207,210,215,217,229,234,235,242,253,287–291 Trichilia (47, 12.7%), 62,233,247,292–297 and Swietenia (35, 9.5%) 219,246,248,298–302 also provide abundant phragmalin-class limonoids (Table S1.12†). The rest, about a quarter of phragmalins, are isolated from 10 genera.…”

Section: Latest Limonoids Discovered From the Meliaceae Familymentioning

confidence: 99%

Research progress of meliaceous limonoids from 2011 to 2021

Luo

Sun

et al. 2022

Nat. Prod. Rep.

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Section: Latest Limonoids Discovered From the Meliaceae Familymentioning

confidence: 99%

Research progress of meliaceous limonoids from 2011 to 2021

Luo

Sun

et al. 2022

Nat. Prod. Rep.

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“…The biological and pharmacological properties of Trichilia species have been reviewed by Longhini et al [ 1 ], Garg [ 12 ], Curcino Vieira et al [ 2 ] and Komane et al [ 13 ]. More recently, limonoids have been studied for their effects on inflammatory disorders [ 14 , 15 ] and as cytotoxic agents [ 9 , 16 , 17 ]. Others report their activity in mouse lymphoma cells [ 18 ], where they inhibit proteins involved in oncogenesis and chemotherapy resistance [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Trichilones A–E: New Limonoids from Trichilia adolfi

et al. 2021

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In addition to the trichilianones A–D recently reported from Trichilia adolfi, a continuing investigation of the chemical constituents of the ethanol extract of the bark of this medicinal plant yielded the five new limonoids 1–5. They are characterized by having four fused rings and are new examples of prieurianin-type limonoids, having a ε-lactone which in 4 and 5 is α, β- unsaturated. The structures of the isolated metabolites were determined by high field NMR spectroscopy and HR mass spectrometry. The new metabolites were shown to have the ε-lactone fused with a tetrahydrofuran ring which is connected to an oxidized hexane ring joined with a cyclo-pentanone having a 3-furanyl substituent. As the crude extract possesses antileishmanial activity, the compounds were assayed for cytotoxic and antiparasitic activities in vitro in murine macrophage cells (raw 264.7 cells) and in Leishmania amazoniensis as well as L. braziliensis promastigotes. Metabolites 1–3 and 5 showed moderate cytotoxicity (between 30–94 µg/mL) but are not responsible for the antileishmanial effect of the extract.

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