Tricarbonylmanganese(I) and –rhenium(I) Complexes of Imidazol‐Based Phosphane Ligands: Influence of the Substitution Pattern on the CO Release Properties

Kunz, Peter C.; Huber, Wilhelm; Rojas, Alfonso; Schatzschneider, Ulrich; Spingler, Bernhard

doi:10.1002/ejic.200900650

Cited by 96 publications

(74 citation statements)

References 50 publications

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“…5). 51 The resulting complexes have similar structures and CO-release properties to 3, with photolability of between one and two equivalents of CO at 365 nm.…”

Section: Ultraviolet Photocormsmentioning

confidence: 87%

PhotoCORMs: CO release moves into the visible

Wright

2016

Dalton Trans.

114

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The potential of carbon monoxide to act as a therapeutic agent is now well-established. Controlled delivery of CO is best achieved using 'CORMs': molecules which release known amounts of carbon monoxide in response to a stimulus. Metal carbonyl complexes will release CO if irradiated with ultraviolet light, but it is only in the past five years that development of true 'photoCORMs' has been explored. Recent exciting developments in this area now show that design of photoCORMs operating well into the visible region is achievable. In this Perspective, we examine the growth of photoCORMs from their origins in the photophysics of metal carbonyls to the latest visible-light agents.

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“…5). 51 The resulting complexes have similar structures and CO-release properties to 3, with photolability of between one and two equivalents of CO at 365 nm.…”

Section: Ultraviolet Photocormsmentioning

confidence: 87%

PhotoCORMs: CO release moves into the visible

Wright

2016

Dalton Trans.

114

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“…To further explore the utility of manganese(I) tricarbonyl complexes with tripodal ligands as CORMs and elucidate some of the structure-activity relationships that govern CO release properties in these compounds, we very recently also started to study the tris(2-and 4-imidazolyl)phosphane (tip) analogues of the tpm complexes with various substituents on both the imidazole rings as well as the bridging phosphorus atom (Figure 18). [184] All compounds are stable in the dark for an extended period of time and, thus, do not release CO spontaneously in aqueous solution in the absence of light, as also observed for the related [Mn(tpm)(CO) 3 ] + systems. Upon photoactivation at 365 nm, all five complexes studied showed CO release in Figure 18.…”

Section: Light-inducible Co Releasing Molecules (Corms)mentioning

confidence: 73%

Photoactivated Biological Activity of Transition‐Metal Complexes

2010

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Keywords: Photochemistry / CO releasing molecules / NO releasing molecules / Biological activity / Prodrugs / DNA cleavage Photochemical activation is a very attractive way to achieve precise spatial and temporal control of the biological action of transition-metal complexes that behave as inactive "prodrugs" in the dark. A significant amount of work has been devoted to metal complexes that act on DNA. In this area, focus has been on ruthenium and rhodium polypyridyl compounds, but copper, iron, cobalt, and vanadium complexes also find increasing application as photoactivable DNA cleaving agents, with excitation sometimes even possible in the near IR region. Most often, the activity of these systems is based on the formation of reactive radical species. Another

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“…The n-octanol/water distribution coefficients (logD 7.4 ) of the complexes were measured using the shake-flask method 28 and are summarised in Table 2.…”

Section: Lipophilic Character Of the Complexesmentioning

confidence: 99%

Rhenium tetrazolato complexes coordinated to thioalkyl-functionalised phenanthroline ligands: synthesis, photophysical characterisation, and incubation in live HeLa cells

et al. 2015

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Three new complexes of formulation fac-[Re(CO) 3 (diim)L], where diim is either 1,10-phenanthroline or 1,10-phenanthroline functionalised at position 5 by a thioalkyl chain, and L is either a chloro or aryltetrazolato ancillary ligand, were synthesised and photophysically characterised. The complexes exhibit phosphorescent emission with maxima around 600 nm, originating from triplet metal-to-ligand charge transfer states with partially mixed ligand-to-ligand charge transfer character. The emission is relatively long-lived, within the 200-400 ns range, and with quantum yields of 2-4%. The complexes were trialed as cellular markers in live HeLa cells, along with two previously reported rhenium tetrazolato complexes bound to unsubstituted 1,10-phenanthroline. All five complexes exhibit good cellular uptake and non-specific perinuclear localisation. Upon excitation at 405 nm, the emission from the rhenium complexes could be clearly distinguished from autofluorescence, as demonstrated by spectral detection within the live cells.Four of the complexes did not appear to be toxic, however prolonged excitation could result in membrane blebbing. No major sign of photobleaching was detected upon multiple imaging on the same cell sample.2

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Tricarbonylmanganese(I) and –rhenium(I) Complexes of Imidazol‐Based Phosphane Ligands: Influence of the Substitution Pattern on the CO Release Properties

Cited by 96 publications

References 50 publications

PhotoCORMs: CO release moves into the visible

PhotoCORMs: CO release moves into the visible

Photoactivated Biological Activity of Transition‐Metal Complexes

Rhenium tetrazolato complexes coordinated to thioalkyl-functionalised phenanthroline ligands: synthesis, photophysical characterisation, and incubation in live HeLa cells

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