Tributyltin causes obesity and hepatic steatosis in male mice

Zuo, Zhenghong; Chen, Shuzhen; Wu, Tian; Zhang, Jiliang; Su, Ying; Chen, Yixin; Wang, Chonggang

doi:10.1002/tox.20531

Cited by 128 publications

(90 citation statements)

References 38 publications

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“…e adipose tissues can be also the target of EDC that alters its functions, by increasing adipose tissue in ammation or modulating the di erentiation of adipose precursor cells. For instance, TBT which acts on nuclear receptors involved in fat metabolism and regulation of glucose uptake, induces in animals hepatic steatosis, hyperinsulinemia, hyperleptinemia and a reduction in hepatic adiponectin levels, in a dose-dependent fashion (11). Similar results, meaning the developed insulin resistance syndrome, abdominal obesity and hepatosteatosis were obtained in adult Sprague-Dawley rats exposed for 28 days to crude salmon oil containing POP (12).…”

Section: Introductionsupporting

confidence: 59%

Adipose tissue accumulation of endocrine disrupting compounds: Variant of a common theme in exposome research

et al. 2014

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Today, a wide variety of exogenous agents (xenobiotics) collectively termed endocrine disrupting compounds (EDC) includes almost 1000 synthetic chemicals. The group of EDC is highly heterogeneous and embodies chemicals used as industrial solvents and their by-products (persistent organic pollutants and dioxins), plastics (bisphenol A) and various pesticides, herbicides and industrial pollutions. The concept of endocrine disruption refers to exogenous chemicals present in the environment, including the food and drugs, that a ect human's hormonal systems. Both epidemiological and experimental evidence suggest an association between exposure to EDC and diabetes and related cardiometabolic disorders. These compounds are not just accumulate in the white adipose tissue, but also release into the blood circulation and exhibit their pathogenic e ects on various organs. The present review is focused on the factors in uencing the accumulation, metabolism and release of EDC in the white adipose tissue. 2014; 6: 15-22 Adipobiology

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Section: Introductionsupporting

confidence: 59%

Adipose tissue accumulation of endocrine disrupting compounds: Variant of a common theme in exposome research

et al. 2014

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“…Recent reports indicate that TBT increases body weight in male mice [14]. In our previous study, we have found that chronic and repeated exposure to low doses of TBT disturbs levels of key hormones linked to energy homeostasis [1]. These findings suggest a peripheral role of TBT on obesity.…”

Section: Reverse-transcriptional Real-time Pcr (Rt-pcr)mentioning

confidence: 57%

“…Organotin compounds, such as tributyltin (TBT), are used in a wide variety of consumer products, for example in agriculture and industry as biocide, heat stabiliser and chemical catalyst [1]. Although TBT has been banned from paints in the European Union since 2003 (EC Regulation 782/2003), it is still found at high levels in marine and freshwater ecosystems exceeding toxicity levels [2].…”

Section: Introductionmentioning

confidence: 99%

Wpływ tributylocyny na przyjmowanie pokarmu i ekspresję neuropeptydów w mózgu szczurów

Zhang

Chen

2015

Endokrynologia Polska

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Introduction: Tributyltin (TBT) is a largely diffused environmental pollutant. Several studies have demonstrated that TBT is involved in the development of obesity. However, few studies addressing the effects of TBT on the brain neuropeptides involved in appetite and body weight homeostasis have been published. Material and methods: Experiments were carried out on female and male Sprague-Dawley rats. Animals were exposed to TBT (0.5 μg/kg body weight) for 54 days. The hepatic triglyceride and total cholesterol were determined using commercial enzyme kits. The NPY, AgRP, POMC and CART mRNA expression in brains were quantified by real-time PCR. Results: TBT exposure resulted in significant increases in the hepatic total cholesterol and triglyceride concentration of both male and female rats. Interestingly, increases in body weight and fat mass were only found in the TBT-treated male rats. TBT exposure also led to a significant increase in food intake by the female rats, while no change was observed in the male rats. Moreover, the neuropeptides expression was different between males and females after TBT exposure. TBT induced brain NPY expression in the female rats, and depressed brain POMC, AgRP and CART expression in the males. Conclusions: TBT can increase food intake in female rats, which is associated with the disturbance of NPY in brains. TBT had sex-different effects on brain NPY, AgRP, POMC and CART mRNA expression, which indicates a complex neuroendocrine mechanism of TBT.

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“…It has been reported there is a health risk related to organotin exposure in mammalian species (Zuo et al, 2011). These organometallic chemicals, in particular TBT, the organotin chemical linked to imposex, accumulate primarily in fetal tissues, eventually leading to an impaired role of sexual enzymes and normal fetal development.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it has also been associated with obesity in mice (Graceli et al, 2013). This effect is important during the differentiation of adipocytes; the activation of proteins and receptors related to fat storage (Kirchner et al, 2010); and the imbalance of chemokines, interleukins, leptin (Carfi et al, 2008), and insulin (Zuo et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Imposex in Stramonita haemastoma from coastal sites of Cartagena, Colombia

Sierra-Marquez

Rosa

et al. 2017

Braz. J. Biol.

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Imposex is the development of male sexual characteristics caused by the toxic effects of some chemicals that acts as an endocrinal disruptor. Antifouling paints contain these chemicals. Cartagena lacks studies to indicate the extent of imposex in its coastal waters. The aim of this study was to determine the prevalence of imposex in the gastropod Stramonita haemastoma in Cartagena, Colombia. Specimens were collected during 2013 from locations of high and low influence of port activity. Morphometric measurements and the frequency of the occurrence of imposex were registered. The comparison among morphometric variables showed statistically significant differences between the two sites studied. Furthermore, the females of the S. haemastoma species presented an imposex frequency of 93.1% in Birds' Island, Cartagena Bay, compared to 31.8% in La Bocana. The relative penis size index or RPLI (10.145 and 3.231) and vas deferens sequence index or VDSI (2.83 and 1.16), showed possible contamination by organotin compounds in both places.Keywords: imposex, bioaccumulation, boat paint, organotin compounds, penis development, toxicity. Palavras-chave: imposex, bioacumulação, pintura para barco, compostos organoestânicos, desenvolvimento do pênis, toxicidade. Imposex em

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Tributyltin causes obesity and hepatic steatosis in male mice

Cited by 128 publications

References 38 publications

Adipose tissue accumulation of endocrine disrupting compounds: Variant of a common theme in exposome research

Adipose tissue accumulation of endocrine disrupting compounds: Variant of a common theme in exposome research

Wpływ tributylocyny na przyjmowanie pokarmu i ekspresję neuropeptydów w mózgu szczurów

Imposex in Stramonita haemastoma from coastal sites of Cartagena, Colombia

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