Tributyltin causes masculinization in fish

Shimasaki, Yohei; Kitano, Takeshi; Oshima, Yuji; Inoue, Suguru; Imada, Nobuyoshi; Honjo, Tasuku

doi:10.1002/etc.5620220118

Cited by 160 publications

(37 citation statements)

References 33 publications

(41 reference statements)

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“…Despite this, TBT has also induced hermaphroditism in M. rosenbergii . Supportively, Shimasaki et al [63] found that the TBT has potentially induced masculinization to the extent of complete sex reversal in the genetically female Japanese flounder Paralichthys olivaceus .…”

Section: Discussionmentioning

confidence: 99%

TBT Effects on the Development of Intersex (Ovotestis) in Female Fresh Water PrawnMacrobrachium rosenbergii

Revathi

Iyapparaj

Lourdaraj

et al. 2014

BioMed Research International

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The impact of tributyltin (TBT) on the female gonad and the endocrine system in Macrobrachium rosenbergii was studied. Prawns were exposed to environmentally realistic concentrations of 10, 100, and 1000 ng/L of TBT for 6 months. Dose dependent effects were noticed in TBT exposed prawns. At 1000 ng/L TBT caused ovotestis formation (formation of male germ cells in ovary). Presence immature oocytes, fusion of developing oocytes, increase in interstitial connective tissues, and its modification into tubular like structure and abundance of spermatogonia in the ovary of TBT treated prawns. The control prawn ovary showed normal architecture of cellular organelles such as mature oocytes with type 2 yolk globules, lipid droplets, normal appearance of yolk envelop, and uniformly arranged microvilli. On the other hand, type 1 yolk globules, reduced size of microvilli, spermatogonial cells in ovary, spermatogonia with centrally located nucleus, and chromatin distribution throughout the nucleoplasm were present in the TBT treated group. Immunofluorescence staining indicated a reduction in vitellin content in ovary of TBT treated prawn. Moreover, TBT had inhibited the vitellogenesis by causing hormonal imbalance in M. rosenbergii. Thus, the present investigation demonstrates that TBT substantially affects sexual differentiation and gonadal development in M. rosenbergii.

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Section: Discussionmentioning

confidence: 99%

TBT Effects on the Development of Intersex (Ovotestis) in Female Fresh Water PrawnMacrobrachium rosenbergii

Revathi

Iyapparaj

Lourdaraj

et al. 2014

BioMed Research International

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“…Hardly a decade after organotins were introduced, the first reports of imposex in snails surfaced 29-30 and subsequent studies identified TBT as the causative agent 31-33 . Given that snails lack most vertebrate orthologs of sex steroid receptors (e.g., androgen and progesterone receptors) 34 , this result did not interest vertebrate developmental biologists until 2003 when TBT was shown to masculinize female fish 35-36 . The mechanism proposed was that TBT inhibited aromatase action, thereby preventing the biosynthesis of estradiol from testosterone 37-38 .…”

Section: A Brief History Of Obesogensmentioning

confidence: 99%

Obesogens: an emerging threat to public health

Janesick¹,

Blumberg²

2016

American Journal of Obstetrics and Gynecology

189

141

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Endocrine disrupting chemicals (EDCs) are defined as exogenous chemicals, or mixture of chemicals, that can interfere with any aspect of hormone action. The field of endocrine disruption is historically rooted in wildlife biology and reproductive endocrinology where EDCs are demonstrated contributors to infertility, premature puberty, endometriosis, and other disorders. Recently, EDCs have been implicated in metabolic syndrome and obesity. Adipose tissue is a true endocrine organ and, therefore, an organ which is highly susceptible to disturbance by EDCs. A subset of EDCs, called “obesogens” promote adiposity by altering programming of fat cell development, increasing energy storage in fat tissue, and interfering with neuroendocrine control of appetite and satiety. Obesity adds more than $200 billion to U.S. healthcare costs and the number of obese individuals continues to increase. Hence, there is an urgent, unmet need to understand the mechanisms underlying how exposures to certain EDCs may predispose our population to be obese. In this review, we discuss the history of obesogen discovery from its origins in reproductive biology to its latest role in the transgenerational inheritance of obesity in mice. We discuss the development of adipose tissue in an embryo, maintenance of adipocyte number in adults, how EDC disruption programs stem cells to preferentially make more adipocytes, the mechanisms by which chemicals can permanently alter the germline epigenome, and whether there are barriers to EDCs in the gametes.

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“…Effects of TBT have been investigated in several aquatic organisms, including algae [5] and crustaceans [6]. Champ [7] reported that TBT inhibits growth, reproduction [8,9] and sexual differentiation in fishes [10]. In our previous study, we documented the inhibition of organogenesis as well as embryonic development in M. rosenbergii due to TBT toxicity [11].…”

Section: Introductionmentioning

confidence: 99%

Impact of TBT on the vitellogenesis and sex hormones in freshwater prawn Macrobrachium rosenbergii (De Man, 1879)

et al. 2013

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BackgroundTributyltin (TBT) is a ubiquitous persistent xenobiotic that can be found in freshwater, estuarine and marine ecosystem. TBT is a strong endocrine disrupting compound (EDC) that can cause toxic threat to aquatic organisms. Imposex, sexual deformities and endocrine dysfunctions are the causes of TBT to most of the aquatic organisms. Effect of TBT on the vitellogenesis and sex hormonal changes in Macrobrachium rosenbergii has never been reported. Hence, the present investigation was undertaken to find out the impact of TBT on histological changes in the different reproductive tissues, sex hormonal alterations and level of biomarkers like vitellogenin and vitellin in M. rosenbergii.ResultsThe present investigation documents the possible impact of tributyltin (TBT) on the vitellogenesis in freshwater female prawn M. rosenbergii. TBT at 10 ng/l, 100 ng/l and 1000 ng/l concentrations were exposed individually to prawns for a period of three months. At higher concentration of 1000 ng/l, the ovarian development was arrested and ovary remained at spent stage. At lower concentration of TBT (10 ng/l), the development proceeded up to early vitellogenic stage. At intermediate concentration of 100 ng/l TBT, the ovary remained at pre vitellogenic stage and thereafter no development was noticed. Histological results indicated the normal ovarian development with vitellogenic oocytes, filled with yolk globules in control prawn. On the other hand, the TBT treated groups showed reduction in yolk globules, fusion of developing oocytes and abundance of immature oocytes. Immunofluorescence staining denoted the remarkable reduction in vitellin content in ovary of TBT treated prawn. Hence, TBT had conspicuously inhibited the vitellogenesis by causing hormonal imbalance in M. rosenbergii.ConclusionTBT had notably inhibited the vitellogenesis due to hormonal imbalance. This endocrine dysfunction ultimately impaired the oogenesis in the freshwater female prawn M. rosenbergii.

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Tributyltin causes masculinization in fish

Cited by 160 publications

References 33 publications

TBT Effects on the Development of Intersex (Ovotestis) in Female Fresh Water PrawnMacrobrachium rosenbergii

TBT Effects on the Development of Intersex (Ovotestis) in Female Fresh Water PrawnMacrobrachium rosenbergii

Obesogens: an emerging threat to public health

Impact of TBT on the vitellogenesis and sex hormones in freshwater prawn Macrobrachium rosenbergii (De Man, 1879)

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