Tributyltin and triphenyltin induce 11β-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor α

Inderbinen, Silvia G.; Engeli, Roger T.; Rohrer, Simona R.; Renzo, Erminio Di; Aengenheister, Leonie; Buerki-Thurnherr, Tina; Odermatt, Alex

doi:10.1016/j.toxlet.2020.01.001

Cited by 9 publications

(3 citation statements)

References 93 publications

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“…In vitro, EDCs can interact with HSD11B1/2 followed by altered expression and activity in multiple target tissues of glucocorticoids 34 . For instance, TBT alters HSD11B2 expression and enzymatic activity in placental cells and thereby enhances cortisol deactivation 67 .…”

Section: Steroidogenic Enzyme Expressionmentioning

confidence: 99%

Endocrine Disruptors: Focus on the Adrenal Cortex

Pötzl,

Kürzinger,

Stopper

et al. 2023

Horm Metab Res

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Endocrine-disrupting chemicals (EDCs) are exogenous substances known to interfere with endocrine homeostasis and promote adverse health outcomes. Their impact on the adrenal cortex, corticosteroids and their physiological role in the organism has not yet been sufficiently elucidated. In this review, we collect experimental and epidemiological evidence on adrenal disruption by relevant endocrine disruptors. In vitro data suggest significant alterations of gene expression, cell signalling, steroid production, steroid distribution, and action. Additionally, morphological studies revealed disturbances in tissue organization and development, local inflammation, and zone-specific hyperplasia. Finally, endocrine circuits, such as the hypothalamic-pituitary-adrenal axis, might be affected by EDCs. Many questions regarding the detection of steroidogenesis disruption and the effects of combined toxicity remain unanswered. Not only due to the diverse mode of action of adrenal steroids and their implication in many common diseases, there is no doubt that further research on endocrine disruption of the adrenocortical system is needed.

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Section: Steroidogenic Enzyme Expressionmentioning

confidence: 99%

Endocrine Disruptors: Focus on the Adrenal Cortex

Pötzl,

Kürzinger,

Stopper

et al. 2023

Horm Metab Res

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“…The organotins induced 11β-HSD2 expression and activity in JEG-3 placenta cells by activating RXRα, which will cause development problems in the foetus (Inderbinen et al 2020).…”

Section: Retinoid X Receptor (Rxr)mentioning

confidence: 99%

Endocrine disruptors in foods: Overlooked factors contributing to the prevalence of obesity

Wu,

Yang,

KangTan

et al. 2023

Czech J. Food Sci.

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Endocrine disruptors, also known as endocrine-disrupting chemicals, could mimic or interfere with the body's hormones. Indeed, naturally occurring endocrine disruptors have been widely identified in daily foods. Moreover, industrialisation has resulted in increasing synthetic endocrine disruptors being produced and used as food additives or in food package materials, which makes exposure to endocrine disruptors become more common. Although the safety of synthetic chemicals has been extensively evaluated before entering into the food industry, increasing evidence has also highlighted that long-lasting exposure might influence long-term metabolic outcomes and be associated with the prevalence of obesity. Therefore, this review summarised the sources, detection methods, obesogenic effects and possible mechanisms of endocrine disruptors commonly found in foods, as well as discussed possible underlying mechanisms by which endocrine disruptors contribute to the increased risk of obesity. In conclusion, the review may provide useful information for understanding the association between endocrine disruptors and obesity, which could provide a new angle of view for preventing obesity prevalence.

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“…EDCs interfere with many hormone-regulated physiological pathways and have complex effects on human and fish physiology due to the diversity of the hormone receptors and enzymes that they bind [ 10 ]. The detailed mechanisms by which ED compounds act is not completely understood, but many interact with nuclear receptors, such as the retinoid X receptor (RXR) [ 11 , 12 , 13 , 14 ], peroxisome proliferator-activated receptors (PPARs) [ 14 , 15 , 16 , 17 , 18 ] and estrogen receptors (ERs) [ 19 , 20 ]. The binding of EDCs to these and other receptors, as well as steroidogenic enzymes, can perturb normal physiological processes.…”

Section: Introductionmentioning

confidence: 99%

Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes

Verga

Huff

Owens

et al. 2022

IJERPH

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Exposure to Endocrine Disrupting Chemicals (EDC) has been linked with several adverse outcomes. In this review, we examine EDCs that are pervasive in the environment and are of concern in the context of human, animal, and environmental health. We explore the consequences of EDC exposure on aquatic life, terrestrial animals, and humans. We focus on the exploitation of genomics technologies and in particular whole transcriptome sequencing. Genome-wide analyses using RNAseq provides snap shots of cellular, tissue and whole organism transcriptomes under normal physiological and EDC perturbed conditions. A global view of gene expression provides highly valuable information as it uncovers gene families or more specifically, pathways that are affected by EDC exposures, but also reveals those that are unaffected. Hypotheses about genes with unknown functions can also be formed by comparison of their expression levels with genes of known function. Risk assessment strategies leveraging genomic technologies and the development of toxicology databases are explored. Finally, we review how the Adverse Outcome Pathway (AOP) has exploited this high throughput data to provide a framework for toxicology studies.

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Tributyltin and triphenyltin induce 11β-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor α

Cited by 9 publications

References 93 publications

Endocrine Disruptors: Focus on the Adrenal Cortex

Endocrine Disruptors: Focus on the Adrenal Cortex

Endocrine disruptors in foods: Overlooked factors contributing to the prevalence of obesity

Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes

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