Triboelectric characteristics of mannitol based formulations for the application in dry powder inhalers

Karner, Stefan; Urbanetz, Nora Anne

doi:10.1016/j.powtec.2012.10.034

Cited by 18 publications

(5 citation statements)

References 35 publications

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“…Statistical DOE studies have been carried out by Karner et.al 104,105 to investigate the influence and interactions of particle size, container size and concentration of fines. Detailed studies of a range of particle sizes, suggested that the magnitude of the charge increases continuously with decrease in particle size.…”

Section: Process and Formulation Parametersmentioning

confidence: 99%

Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Naik

Mukherjee

Chaudhuri

2016

International Journal of Pharmaceutics

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Section: Process and Formulation Parametersmentioning

confidence: 99%

Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Naik

Mukherjee

Chaudhuri

2016

International Journal of Pharmaceutics

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“…Therefore, small particles usually tend to carry a greater level of netcharge-to-surface ratio (net-CSR) than the larger particles, i.e., powder charge is inversely related to particle mean diameter (Guardiola et al, 1996;Kaialy et al, 2014;Rowley, 2001). For example, under similar fluidisation conditions, (Karner and Urbanetz, 2013) showed the amount of netcharge accumulated on mannitol powders to increase with the fine fraction of small mannitol.…”

Section: Particle Size Distributionmentioning

confidence: 99%

“…Following the addition of SS drug particles to mannitol carrier particles, drug-carrier DPI formulations demonstrated a higher netcharge than the carrier (Karner and Urbanetz, 2013). (Elajnaf et al, 2006) studied the role of tribocharging in interparticle interactions between micronised SS and ipratropium bromide with lactose (α-lactose monohydrate, 63 μm to 90 μm) during mixing in different blending vessels.…”

Section: Drugs Carriers and Contact Surfacesmentioning

confidence: 99%

A review of factors affecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation

Kaialy

2016

International Journal of Pharmaceutics

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Pharmaceutical powders are typically insulators consisting of relatively small particles and thus they usually exhibit significant electrostatic charging behaviours. In the inhalation field, the measurement of electrostatic charge is an imperative stage during pharmaceutical formulation development. The electrostatic charge is affected by the interplay of many factors. This article reviews the factors affecting the electrostatic charging of pharmaceutical powders with a focus on dry powder inhalations. The influences of particle resistivity, size distribution, shape distribution, surface roughness, polymorphic form and hygroscopicity, as well as the effects of moisture uptake, environmental conditions, pharmaceutical processing (i.e., milling, sieving, spray drying and blending), and storage on the electrostatic charge behaviours of pharmaceuticals, with focus on inhalation powders, were reviewed. The influence of electrostatic charge on the performance of dry powder inhaler formulations in terms of drug content homogeneity, the passage of drug through the inhaler device, drug-carrier adhesion/detachment, and drug deposition on the respiratory airways were discussed. The understanding gained is crucial to improving the safety, quality, and efficiency of the pharmaceutical inhalation products.

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“…Different from metals and polymers, only little is hitherto known about triboelectrical charging of wood particles and surfaces, as well as the mechanisms involved (Karner and Urbanetz 2013). Among the few studies investigating triboelectric charging of wood particles (e.g., Zhang et al 2013;Myna et al 2021a, b, c), in particular the latter reports are worth noting.…”

Section: Introductionmentioning

confidence: 99%

Triboelectric surface field strength of wood after brushing

Leiter

Myna

Frybort³

et al. 2022

Wood Sci Technol

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Mechanical friction causes electrical surface charges on wooden surfaces. In this research, triboelectric activation of solid wood surfaces was investigated by using a wood brushing machine. The extent of activation and the potential influence of machine parameters, or the influence of various wood species are questions so far unanswered. The electrical surface field strengths were continuously detected by means of an electric field meter. Machine settings, such as feed rate and brush pressure, have been varied to better understand the effects on the resulting surface charges. Data showed that nylon and tynex brushes lead to strong positive electric surface field strengths while natural fibers lead to less positive surface field strengths. In contrast, steel wire brushes showed negative electrical field strengths for oak wood, slightly positive field strengths for beech wood and stronger positive field strengths for softwoods. Overall, the tendency that a higher brush pressure led to higher recorded electrical surface field strengths while a faster feed rate reduced the field strengths was observed. As these findings were influenced by wood species and brushing materials, a better understanding of specific triboelectric interactions is essential for future applications. Tailoring surface charges can be an asset for new technical applications, such as chemistry-free primer treatments prior to wood coating.

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Triboelectric characteristics of mannitol based formulations for the application in dry powder inhalers

Cited by 18 publications

References 35 publications

Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

A review of factors affecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation

Triboelectric surface field strength of wood after brushing

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