Triblock copolymers for nano-sized drug delivery systems

Hoang, Ngoc Ha; Lim, Chaemin; Sim, Taehoon; Oh, Kyung Taek

doi:10.1007/s40005-016-0291-7

Cited by 50 publications

(23 citation statements)

References 70 publications

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“…Owing to the protonation of the carboxylic group at low pH, anionic poly(L-aspartic acid) has been studied as potential pH-sensitive drug carrier [16,17] . The combination of this polyelectrolyte block copolymer on the surface of nanoparticles could be potential to boost the drug release in the acidic environment found in the endosomes of cancer cells [15,16,[18][19][20] . Furthermore, the PEG shell could enable prolonged blood circulation and avoid the rapid elimination of nanoparticles [21,22] .…”

Section: Research Papermentioning

confidence: 99%

Synergistic Therapeutic Strategy of Dual Drug-loaded Lipid Polymer Hybrid Nanoparticles for Breast Cancer Treatment

Tran¹,

Nguyen²,

Chen³

et al. 2019

pharmaceutical-sciences

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Tran et al.: Dual Drug-loaded Lipid Polymer Hybrid Nanoparticles In this investigation, a smart nanocarrier-loaded docetaxel, a microtubules disrupting agent and vorinostat, a histone deacetylase inhibitor was developed to achieve a synergistic anticancer effect. Dual drug-loaded lipid polymer hybrid nanoparticles were prepared, with easy fabrication and favourable properties including small size, narrow distribution and a high loading effi cacy. The in vitro drug release conducted in phosphatebuffered saline, pH 7.4 and acetate-buffered saline, pH 5.5 media demonstrated the sustained, pH-dependent release profi le. The nanoparticles were effectively taken up by cells, which ensured greater suppression of cell growth. The co-delivery of both drugs exhibited a synergistic effect on the induction of cancer cell apoptosis, resulting in greater inhibition of SCC-7, MCF-7, and MDA-MB-231 cancer cells by the drug-loaded carrier. These promising results may lead to clinical applications with enhanced docetaxel activity.

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Section: Research Papermentioning

confidence: 99%

Synergistic Therapeutic Strategy of Dual Drug-loaded Lipid Polymer Hybrid Nanoparticles for Breast Cancer Treatment

Tran¹,

Nguyen²,

Chen³

et al. 2019

pharmaceutical-sciences

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“…Biodegradable polymers that can be used in drug delivery such as poly(ɛ-Caprolactone) (PCL) and poly(ethylene glycol) (PEG) [1]. Triblock copolymers have advantages such as can be applied as a carrier of hydrophilic or hydrophobic drugs, can be varied arrangement of polymer blocks, and can be used for improving drug solubility or controlling drug release [2]. The application of triblock copolymer with the composition of PCL and PEG has existed previously as drug delivery system of drug that has a low solubility (hydrophobic).…”

Section: Introductionmentioning

confidence: 99%

“…PECE triblock copolymer is an analog of commercial polymer that is Poloxamer (PEO-PPO-PEO). Poloxamer has weakness such as non-biodegradable polymer, its mean that polymer does not can be degraded in the body so can cause of toxicity [2]. PECE triblock copolymer expected to be safer to use in drug formulation and has a potential for drug delivery system, so need to be done optimum formula to form a PECE triblock copolymer.…”

Section: Introductionmentioning

confidence: 99%

Optimization and Characterization of Peg-PCL-Peg Triblock Copolymer as Carrier of Drug Using Full Factorial Design

Armatazaka

Sulaiman²,

Zulkarnain

2019

Int J Curr Pharm Sci

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Objective: Triblock copolymer of poly(ethylene glycol)-poly(ɛ-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) was applicated as hydrophobic drug. This study aims to optimization and characterization of PECE triblock copolymer as carriers of hydrophobic drug (ketoprofen).Methods: Triblock copolymer of PECE was prepared with varying composition ratio of PEG and PCL by ring-opening and coupling reaction. The characteristics of triblock copolymer were characterized using FTIR and DSC. Variation composition ratio of poly(ɛ-caprolactone) (PCL)/poly(ethylene glycol) (PEG) and ratio PECE/drug as factors for optimization using full factorial design. Ketoprofen was loaded into PECE triblock copolymer micelles by emulsification and solvent evaporation method. Responses were measured particle size, entrapment efficiency (EE) and drug solubility. Results:The result of this study showed that a higher ratio of PCL/PEG and ratio of PECE/drug, reducing particle size, increasing EE and improving drug solubility. The optimum formula obtained by ratio of PCL/PEG is 2:1 and ratio of PECE/drug is 40:1 with particle size is 356,967±9,142 nm, EE is 57,751±0,437%, drug solubility is 32,648±0,200 µg/ml and zeta potential-18,867±2,578 mV. A full factorial design was applied to determine the optimum formula for the PECE triblock copolymer as drug carriers. Conclusion:The PECE triblock copolymer was preparated using ring-opening polymerization method with Sn(Oct)2 as a catalyst and then continued the reaction with HMDI as coupling agent. Ketoprofen was loaded into PECE triblock copolymer using methods emulsification and solvent evaporation.

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“…In previous reports, poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) was developed for tumor-targeted drug delivery (Song et al., 2016 ; Hoang et al., 2017a , b ). As a biocompatible water-soluble polymer, PEG has widely been utilized as a hydrophilic block because of its outstanding water solubility, chain mobility, nontoxicity, and non-immunogenicity (Yamaoka et al., 1994 ).…”

Section: Introductionmentioning

confidence: 99%

Development of a docetaxel micellar formulation using poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery

et al. 2018

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Docetaxel (DTX)-loaded polymeric micelles (DTBM) were formulated using the triblock copolymer, poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG), to comprehensively study their pharmaceutical application as anticancer nanomedicine. DTBM showed a stable formulation of anticancer nanomedicine that could be reconstituted after lyophilization (DTBM-R) in the presence of PEG 2000 and D-mannitol (Man) as surfactant and protectant, respectively. DTBM-R showed a particle size less than 150 nm and greater than 90% of DTX recovery after reconstitution. The robustly formed micelles might minimize systemic toxicity due to their sustained drug release and also maximize antitumor efficacy through increased accumulation and release of DTX from the micelles. From the pharmaceutical development point of view, DTBM-R showing successful reconstitution could be considered as a potent nanomedicine for tumor treatment.

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Triblock copolymers for nano-sized drug delivery systems

Cited by 50 publications

References 70 publications

Synergistic Therapeutic Strategy of Dual Drug-loaded Lipid Polymer Hybrid Nanoparticles for Breast Cancer Treatment

Synergistic Therapeutic Strategy of Dual Drug-loaded Lipid Polymer Hybrid Nanoparticles for Breast Cancer Treatment

Optimization and Characterization of Peg-PCL-Peg Triblock Copolymer as Carrier of Drug Using Full Factorial Design

Development of a docetaxel micellar formulation using poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery

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