Triblock copolymers containing UCST polypeptide and poly(propylene glycol): Synthesis, thermoresponsive properties, and modification of PVA hydrogel

Zheng, Zelai; Zhang, Lin; Ying, Lei; Tang, Haoyu

doi:10.1016/j.eurpolymj.2019.03.034

Cited by 18 publications

(2 citation statements)

References 56 publications

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“…The phase separation of copolymers consisting of nonionic and cationic repeating units has been intensely explored, good examples being poly( N -isopropylacrylamide) (PNIPAM) copolymers, − poly(2-hydroxyethyl methacrylate) (PHEMA), poly(oligo(ethylene glycol) methacrylate) (POEGMA), poly(ethylene glycol) (PEG), , and poly[oligo(2-ethyl-2-oxazoline)acrylate] P(OEtOxA) . Other cationically derivatized polymers include poly(propylene glycol) (PPG), poly(γ-propyl- l -glutamate) (PPLG), poly(γ-2-ethoxyethyl- l -glutamate) (PEELG), and poly(γ-3-azidopropyl- l -glutamate) (PAPLG) . The changes in the phase separation processes induced by the cationic units may be profound and the system may even change from a LCST to an UCST one.…”

Section: Introductionmentioning

confidence: 99%

Molecular Mass Affects the Phase Separation of Aqueous PEG–Polycation Block Copolymer

et al. 2019

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Mechanisms of the phase separation and remixing of cationic PEG-containing block copolymers have been investigated in aqueous lithium triflate solutions. The polycation was poly(vinylbenzyl trimethylammonium triflate). We have previously reported on one such block copolymer, which upon cooling of a hot clear solution first underwent phase separation into a turbid colloid and, later, partially cleared again with further cooling. To better understand the balance of various interactions in the solutions/dispersions, a series of polymers with varying DP of the cationic block was synthesized. From one of the polymers, the alkyl end group (a fragment of the chain transfer agent) was removed. The length of the cationic block affected critically the behavior, but the hydrophobic end group had a minimal effect. Polymers with a short cationic block turn cloudy and partially clear again during a temperature decrease, whereas those with a long cationic block phase separate and slowly precipitate and remix only when heated. Phase separation takes place via particle formation, and we suggest different mechanisms for colloidal stabilization of particles composed of short or long chains.

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Section: Introductionmentioning

confidence: 99%

Molecular Mass Affects the Phase Separation of Aqueous PEG–Polycation Block Copolymer

et al. 2019

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“…Lipoic acid, dithiolane-3-pentanoic acid derived from organic compound, plays an important role in energy metabolism that can convert blood sugar in our body into energy by using oxygen through aerobic metabolism. Both poly(propylene glycol) [23][24][25] and poly(ethylene glycol) [26][27][28] have been engaged as important hydrophilic and biocompatible synthetic polymers in biomedical applications due to their excellent biocompatible properties such as biocompatible, drug-deliverable, non-immunogenic and ingestible.…”

Section: Introductionmentioning

confidence: 99%

Control of maleic acid-propylene diepoxide hydrogel for 3D printing application for flexible tissue engineering scaffold with high resolution by end capping and graft polymerization

Tran

Kim

et al. 2022

Preprint

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Background Control of 3D printing of highly tough hydrogel inks with adequate printability, scaffold fidelity and mechanical properties are highly desirable for biomedical and tissue engineering applications. However, developing a biocompatible tough ink with high-resolution printability, biodegradability, adhesion, and integration with surrounding tissues is a big challenge in 3D printing. The aim of this study was to develop extrusion-based 3D printing of viscous hydrogel composing of maleic acid and propylene diepoxide by controlling continuous mechanisms of condensation and radical polymerization. Methods The molecular weight of highly adhesive propagating poly(malate-co-propylene oxide) copolymer was controlled by capping its growing chain with mono-functional lipoic acid during condensation reaction to form lipoic acid capped gel (LP-capped gel). Poly(ethylene oxide)-diacrylate, PEGDA, is graft-polymerized to the LP-capped backbone polymer (MPLE gel) by UV irradiation during 3D printing process to control the properties of printability, cell adhesiveness and fidelity with high resolution and mechanical properties (MPLE scaffold). Both the highly adhesive LP-capped gel and printing-controlled MPLE gel/scaffolds are diversely characterized and compared with for their applications to the extrusion-based printability, including biocompatibility, self-healing, drug releasing, adhesiveness, multi-layered high-resolution printing, and in vitro/in vivo tests. Results The ratio at 1:0.3 (w/v) between LP-capped gel and PEGDA was chosen for the optimal results for 3D printing at high resolution (90–140µm in strut thickness) with various complex geometries (lattice, rhombus, and honeycomb). In addition, the long-term release profiles of bioactive molecules were well-controlled by incorporating high molecular BSA (21 days, 98.4 ± 0.69%), or small molecule ORN (14 days, 97.1 ± 1.98%) into the MPLE gel scaffolds for the tests of potential therapeutic applications. More importantly, the MPLE gels represents excellent in vitro cyto-compatibility against osteoblast-like cells (MC3T3) with viability value at 96.43% ± 7.48% over 7 culturing days. For in-vivo studies, the flexible MPLE scaffolds showed significant improvement on angiogenesis with minor inflammatory response after 4-week implantation in mice. Conclusion The MPLE gel inks was well-controlled for the fabrication of flexible complex tissue engineering scaffold with high resolutions, shear-thinning and post-printing fidelity, by modulating the composition of the highly adhesive LP-capped gel and inert PEGDA as well as end capping of lipoic acid to the propagating poly(malate-co-propylene oxide) copolymer.

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Green Chemistry in the Development of Functionalised Hydrogels as Topical Drug‐Delivery Systems

AL‐Rajabi,,

YeitHaan,

2023

Sustainable Approaches in Pharmaceutical Sciences

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Triblock copolymers containing UCST polypeptide and poly(propylene glycol): Synthesis, thermoresponsive properties, and modification of PVA hydrogel

Cited by 18 publications

References 56 publications

Molecular Mass Affects the Phase Separation of Aqueous PEG–Polycation Block Copolymer

Molecular Mass Affects the Phase Separation of Aqueous PEG–Polycation Block Copolymer

Control of maleic acid-propylene diepoxide hydrogel for 3D printing application for flexible tissue engineering scaffold with high resolution by end capping and graft polymerization

Green Chemistry in the Development of Functionalised Hydrogels as Topical Drug‐Delivery Systems

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