Triblock Copolymer Bioinks in Hydrogel Three-Dimensional Printing for Regenerative Medicine: A Focus on Pluronic F127

Shamma, Rehab Nabil; Sayed, Rabab H.; Madry, Henning; Sayed, Nesrine S El; Cucchiarini, Magali

doi:10.1089/ten.teb.2021.0026

Cited by 31 publications

(18 citation statements)

References 131 publications

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Section: ■ Introductionmentioning

confidence: 99%

“…Block copolymers with several functional segments and different compositions have been studied intensively as basic components for construction of high-performance materials . Examples of these block copolymers include diblock, triblock, star-shaped, and hyperbranched polymers. , Polymers possessing both hydrophilic and hydrophilic segments, called amphiphilic polymers, can form a wide range of self-organized architectures, such as micelle and vesicle, via specific molecular interactions (ionic and hydrophobic attractive force). The self-organizing behaviors of amphiphilic polymers have attracted considerable attention in polymer chemistry, , supramolecular chemistry, − and biochemistry. − Moreover, the application of amphiphilic polymers in the industry has recently become an important subject.…”

Section: Introductionmentioning

confidence: 99%

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Amphiphilic Polymers for Color Dispersion: Toward Stable and Low-Viscosity Inkjet Ink

2022

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Amphiphilic random and block copolymers were synthesized as potential inkjet inks. This study evaluated the potential of these polymers for color dispersion by examining the following factors: surface tension, zeta potential, viscosity, and particle size. Acrylic acid and (ethoxyethoxy)ethyl acrylate were used as the hydrophilic molecular units. Styrene, butyl acrylate, and phenoxyethyl acrylate were used as hydrophobic units. Color dispersions were prepared by using organic dye and these amphiphilic polymers. The color dispersions containing random copolymers exhibited low viscosity, which is preferable for jetting, but the dye particles tended to sediment after the thermal aging test. In contrast, those containing block copolymers showed high viscosity, which was unsuitable for jetting. However, they retained their initial dispersion state after the aging test. The advantages and disadvantages of each monomer arrangement (random or block) were demonstrated, providing a future outlook on the molecular design of polymer dispersants for color dispersions.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Amphiphilic Polymers for Color Dispersion: Toward Stable and Low-Viscosity Inkjet Ink

2022

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“…Synthetic materials such as Pluronics, polyisocyanide (PIC), and poly( N -isopropylacrylamide) (PNIPAM) and its derivatives . have more tunable properties and typically higher mechanical strength relative to natural thermoresponsive polymers but can introduce concerns over both the toxicity of the materials themselves (Pluronics) , and/or potentially hard-to-remove residual monomers (PNIPAM) as well as the often poor clearance of such materials following gel dissolution, both of which create challenges with practical in vivo use.…”

Section: Conventional Cross-linking Strategies For Hydrogel Bioinksmentioning

confidence: 99%

Click Chemistry Hydrogels for Extrusion Bioprinting: Progress, Challenges, and Opportunities

et al. 2022

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The emergence of 3D bioprinting has allowed a variety of hydrogel-based “bioinks” to be printed in the presence of cells to create precisely defined cell-loaded 3D scaffolds in a single step for advancing tissue engineering and/or regenerative medicine. While existing bioinks based primarily on ionic cross-linking, photo-cross-linking, or thermogelation have significantly advanced the field, they offer technical limitations in terms of the mechanics, degradation rates, and the cell viabilities achievable with the printed scaffolds, particularly in terms of aiming to match the wide range of mechanics and cellular microenvironments. Click chemistry offers an appealing solution to this challenge given that proper selection of the chemistry can enable precise tuning of both the gelation rate and the degradation rate, both key to successful tissue regeneration; simultaneously, the often bio-orthogonal nature of click chemistry is beneficial to maintain high cell viabilities within the scaffolds. However, to date, relatively few examples of 3D-printed click chemistry hydrogels have been reported, mostly due to the technical challenges of controlling mixing during the printing process to generate high-fidelity prints without clogging the printer. This review aims to showcase existing cross-linking modalities, characterize the advantages and disadvantages of different click chemistries reported, highlight current examples of click chemistry hydrogel bioinks, and discuss the design of mixing strategies to enable effective 3D extrusion bioprinting of click hydrogels.

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“…Among the advanced technologies, utilizing computer-aided design (CAD) is the three-dimensional (3 D) printing. 3 D printing technologies has been characterized as an effective fabrication technique for customized scaffolds based on tissue engineering and antibiotic therapy (Mills et al., 2018 ; Elkasabgy et al., 2020 ; El-Habashy et al., 2021 ; Shamma et al., 2021 ). They showed promising potential in construction scaffolds fitting to the shape and site of the bone defect through controlling the cornerstones of 3 D printing such as accuracy and speed of fabrication (Xu et al., 2010 ; Seol et al., 2012 ; Lee et al., 2013 ).…”

Section: Systems Under Investigation For the Local Delivery Of Antibiotic For Osteomyelitis Managementmentioning

confidence: 99%

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

et al. 2021

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Triblock Copolymer Bioinks in Hydrogel Three-Dimensional Printing for Regenerative Medicine: A Focus on Pluronic F127

Cited by 31 publications

References 131 publications

Amphiphilic Polymers for Color Dispersion: Toward Stable and Low-Viscosity Inkjet Ink

Amphiphilic Polymers for Color Dispersion: Toward Stable and Low-Viscosity Inkjet Ink

Click Chemistry Hydrogels for Extrusion Bioprinting: Progress, Challenges, and Opportunities

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

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