Triazole fungicides exert neural differentiation alteration through H3K27me3 modifications: In vitro and in silico study

Ku, Tingting; Tan, Xin; Liu, Yutong; Wang, Rui; Fan, Li; Ren, Zhihua; Xia, Ning; Li, Guangke; Sang, Nan

doi:10.1016/j.jhazmat.2023.132225

Cited by 9 publications

(1 citation statement)

References 58 publications

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“…Hydrogen bonds dominate the interaction between GQDs and DNMT1. The strength of this electrostatic interaction depends on the magnitude of the charges, the number of binding sites, and the distance between them. − Earlier studies on the structural effects of quantum dot pollutants indicated that excess binding sites enhance electrostatic interaction and a high binding affinity is associated with low binding energy . Binding sites and binding energies are listed in Table S4.…”

Section: Results and Discussionmentioning

confidence: 99%

Retinal Degeneration Response to Graphene Quantum Dots: Disruption of the Blood–Retina Barrier Modulated by Surface Modification-Dependent DNA Methylation

Liu,

Tan,

Wang

et al. 2024

Environ. Sci. Technol.

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Graphene quantum dots (GQDs) are used in diverse fields from chemistry-related materials to biomedicines, thus causing their substantial release into the environment. Appropriate visual function is crucial for facilitating the decisionmaking process within the nervous system. Given the direct interaction of eyes with the environment and even nanoparticles, herein, GQDs, sulfonic acid−doped GQDs (S-GQDs), and aminofunctionalized GQDs (A-GQDs) were employed to understand the potential optic neurotoxicity disruption mechanism by GQDs. The negatively charged GQDs and S-GQDs disturbed the response to light stimulation and impaired the structure of the retinal nuclear layer of zebrafish larvae, causing vision disorder and retinal degeneration. Albeit with sublethal concentrations, a considerably reduced expression of the retinal vascular sprouting factor sirt1 through increased DNA methylation damaged the blood−retina barrier. Importantly, the regulatory effect on vision function was influenced by negatively charged GQDs and S-GQDs but not positively charged A-GQDs. Moreover, cluster analysis and computational simulation studies indicated that binding affinities between GQDs and the DNMT1−ligand binding might be the dominant determinant of the vision function response. The previously unknown pathway of blood−retinal barrier interference offers opportunities to investigate the biological consequences of GQD-based nanomaterials, guiding innovation in the industry toward environmental sustainability.

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