Triazolam discrimination by humans under a novel response procedure

Jb, Kamien; Wk, Bickel; Ah, Oliveto; Bj, Smith; St, Higgins; Hughes, Victoria; Gj, Badger

doi:10.1097/00008877-199406000-00009

Cited by 18 publications

(17 citation statements)

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“…The Þnding that buspirone shows both similarities and di¤erences in its discriminative stimulus e¤ects relative to benzodiazepines is consistent with the observation of both similarities and di¤erence in buspirones proÞle of subjective e¤ects relative to benzodiazepines (e.g., Johanson 1991;Troisi et al 1993;Kamien et al 1994;Rush et al 1995;Evans et al 1996). The Þnding that the present study and the Kamien et al (1994) study revealed a distinct proÞle of discriminative stimulus e¤ects for buspirone, whereas Johansons studies revealed a similar proÞle of e¤ects, may be related to procedural di¤erences between the studies.…”

Section: Discussionsupporting

confidence: 77%

“…The Þnding that the present study and the Kamien et al (1994) study revealed a distinct proÞle of discriminative stimulus e¤ects for buspirone, whereas Johansons studies revealed a similar proÞle of e¤ects, may be related to procedural di¤erences between the studies. Johansons studies used a two-response procedure in which the discriminative stimulus e¤ects of a novel drug were tested by requiring subjects to choose between a drug-appropriate response (i.e., like the training drug) and a placebo-appropriate response.…”

Section: Discussionsupporting

confidence: 40%

“…The results of previous human studies which have examined the discriminative stimulus e¤ects of buspirone relative to benzodiazepines are mixed. Whereas the results of two studies reported by Johanson (1991Johanson ( , 1993 suggest that the discriminative stimulus e¤ects of buspirone are similar to those of benzodiazepines, the results of a study by Kamien et al (1994) suggest that the discriminative stimulus e¤ects of buspirone di¤er from those of benzodiazepines.…”

Section: Discussionmentioning

confidence: 91%

“…In another study (Johanson 1993), diazepam (10 mg) and triazolam (0.25 mg) occasioned drug-appropriate identiÞcations in all eight subjects trained to discriminate between buspirone (15 mg) and placebo. In contrast to Johansons (1991Johansons ( , 1993 Þndings, the results of a study by Kamien et al (1994), which used the novelresponse procedure developed by Bickel and his colleagues (Bickel et al 1993), suggest that the discriminative stimulus e¤ects of buspirone di¤er from those of benzodiazepines. In the novel-response procedure, subjects are provided with a response alternative appropriate for novel drug e¤ects in addition to response alternatives appropriate for training drug and placebo e¤ects.…”

Section: Introductionmentioning

confidence: 91%

“…Buspirone produces less sedation and psychomotor and cognitive impairment than benzodiazepines (e.g., Mattila et al 1982Mattila et al , 1986Wheatley 1982; Barbee et al 1992;Troisi et al 1993) and does not potentiate the performanceimpairing e¤ects of alcohol (Mattila et al 1982;Rush and Gri¦ths 1997). At doses which produce comparable subject ratings of overall drug strength, buspirone produces lower subject ratings of positive drug e¤ects (e.g., drug liking, good e¤ects, friendliness), and higher subject ratings of negative drug e¤ects (e.g., drug disliking, bad e¤ects, tension, and anxiety) than lorazepam (e.g., Troisi et al 1993) and diazepam (e.g., Kamien et al 1994;Rush et al 1995;Evans et al 1996). Buspirone has also been shown to produce lower subject ratings of sedative e¤ects on some measures (e.g., drowsy, fatigue) than lorazepam (Troisi et al 1993) and diazepam (e.g., Johanson 1991;Rush et al 1995); however, on other measures, buspirone has been shown to produce subject ratings of sedative e¤ects comparable to those of lorazepam (Troisi et al 1993) and diazepam (e.g., Evans et al 1996).…”

Section: Introductionmentioning

confidence: 99%

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Buspirone is differentiated from diazepam in humans using a three-response drug discrimination procedure

et al. 1998

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The discriminative stimulus effects of buspirone and diazepam were examined in 12 healthy volunteers using a three-response drug discrimination procedure and a within-subject design. During an initial sampling phase, the training drug conditions (placebo, 15 mg/70 kg buspirone, and 10 mg/70 kg diazepam) were identified to subjects by letter codes before oral drug administration. During a subsequent training phase, subjects earned money for correct drug identifications made two hours after drug administration. Ten out of 12 subjects acquired the three-response discrimination. When lower doses of buspirone (3.75 and 7.5 mg/70 kg) and diazepam (2.5 and 5.0 mg/70 kg) were tested in a subsequent generalization testing phase, both buspirone and diazepam produced dose-related increases in appropriate drug identifications, without significant cross-generalization. Analyses of standardized and unstructured self report questionnaires revealed that buspirone and diazepam produced different profiles of effects, and that buspirone was associated with a number of "negative" subject-rated effects including tension, nausea, and dizziness. These results demonstrate a distinct profile of discriminative stimulus and subjective effects for buspirone relative to diazepam which is consistent with its distinct pharmacological profile, and provide evidence for the sensitivity of the three-response drug discrimination procedure.

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