Triamcinolone-Assisted Removal of Internal Limiting Membrane Enhances the Effect of Vitrectomy for Diabetic Macular Edema

Yamakoshi, Takehiro; Kachi, Shu; Sugita, Jiro; Asami, Tetsu; Ishikawa, Kohei; Ito, Yasuki; Terasaki, Hiroko

doi:10.1159/000217724

Cited by 10 publications

(3 citation statements)

References 60 publications

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“…Three studies [6,7,11] (total 176 eyes) showed CMT changes pre-and post-operation, as shown in Fig. 3C.…”

Section: Central Macular Thickness (Cmt)mentioning

confidence: 98%

“…The eligible 10 studies[6-15] included 1126 eyes with DME that were enrolled in this meta-analysis (485 eyes with ILM peeling, 641 eyes with no ILM peeling). Among these studies, 5 RCTs[6-10] and 5 nonrandomized trials [11][12][13][14][15] were published from 2004 to 2015. The average patients' age ranged from 54 to 73 years old.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Yamamoto et al [6] and Yamakoshi et al [11] found that macular oedema vanished through the optical coherence tomography (OCT) manifestation of the reduction of CMT in the ILM peeling group, while Hoerauf et al [7] found that CMT increased after surgery in the ILM group. There was signi cant heterogeneity across the studies (I 2 = 90%, τ 2 = 4042.6900, p < 0.01) due to the variations in diagnostic criteria for macular oedema.…”

Section: Central Macular Thickness (Cmt)mentioning

confidence: 99%

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Pars Plana Vitrectomy for refractive Diabetic Macular Oedema with or without Internal Limiting Membrane Peeling: A systemic Review and Meta-Analysis

Miao

Zeng²,

Chen³

et al. 2023

Preprint

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Objective: To determine whether pars plana vitrectomy (PPV) combined with the internal limiting membrane (ILM) peeling technique improves the anatomic and functional outcomes of refractory diabetic macular oedema (DME) in comparison with PPV alone. Methods: All relevant articles published in English were retrieved from PubMed, google scholar, web of Science, scopes, and Cochrane library databases between January 1st 1990 and September 28 2022. The meta-analysis was conducted using the Statistical software R 4.2.2. Results: Among 709 articles that were initially identified, 10 studies involving 1126 eyes with DME were found to be eligible for this meta-analysis and systematic review. Our results revealed that postoperative best corrected visual acuity (BCVA) was better in the non-peeling group than in the ILM peeling group (MD=-0.08, 95% CI: -0.12, -0.04, p<0.001), the improvement of BCVA was not significant between the two groups (RD=5.59, 95% CI: -4.81, 15.99, p=0.13). The random effects model showed that changes in central macular thickness were not significantly different between the ILM peeling group and the non-ILM peel group (MD=23.10, 95% CI: -53.82, 100.02, p=0.56). Conclusion: The functional and morphological clinical outcomes in the non-inferior group are equal to that of the ILM peeling group. Yet, further large-scale prospective, randomized, controlled trials are warranted to further validate the reported results.

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“…Three studies [6,7,11] (total 176 eyes) showed CMT changes pre-and post-operation, as shown in Fig. 3C.…”

Section: Central Macular Thickness (Cmt)mentioning

confidence: 98%