Triamcinolone acetonide suspension toxicity to corneal endothelial cells

Abstract

Commercial TA suspension was cytotoxic to cultured rabbit CECs because of the preservative, BA, in the vehicle. Because 1/10 -vTA appeared to be safe for up to 30 minutes of exposure, use of 1/10 dilutions of vehicle-removed TA is suggested to help surgeons visualize prolapsed vitreous during anterior vitrectomy in complicated cataract surgeries.

Triamcinolone-assisted vitrectomy in pediatric cataract surgery: Intraoperative effectiveness and postoperative outcome

“…In several studies, the preserved form of commercial triamcinolone acetonide suspension caused damage to human and rabbit retinal pigment epithelial cells, 17 rabbit corneal endothelial cells, 18 and to proliferating cells of retinal origin in vitro at doses normally used in clinical practice. 19 Vehicle-free triamcinolone acetonide suspensions do not seem to damage human retinal pigment epithelial cells.…”

Effect of intracameral triamcinolone acetonide on postoperative intraocular pressure after cataract surgery

“…8 Oh et al 9 applied TA intracamerally into rabbit eyes to investigate the effect of TA on the corneal endothelium and showed reduced microvilli, although no statistically significant differences in endothelial counts and central corneal thickness were observed at 2 h after the experimental procedure. Chang et al 10 showed toxicity of TA on cultured endothelium in their experimental study.…”

Congenital cataract surgery with intracameral triamcinolone: Pre- and postoperative central corneal thickness and intraocular pressure

“…1 Published studies have reported varied incidences of ocular hypertension secondary to triamcinolone use, ranging from 21% after sub-Tenon's injections [3][4][5] to 56% after intravitreal injections. 10,22,23 In addition to the risk of increased IOP due to triamcinolone use, pseudophakic children face a greater risk of developing ocular hypertension and glaucoma after the congenital cataract surgery itself, 11,12 which has been reported in up to 24.4% of patients. 12 There was no significant difference in the mean CCT before and after surgery in the current study.…”