Triamcinolone acetonide in the treatment of acute and chronic lesions of the oral mucous membranes

Zegarelli, Edward V.; Kutscher, Austin H.; Silvers, Herbert F.; Beube, Frank E.; Stern, Irving B.; Berman, Charles L.; Herlands, Robert E.

doi:10.1016/0030-4220(60)90426-6

Cited by 43 publications

(6 citation statements)

References 5 publications

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“…The corticosteroids vary in their degree of potency and may be given as mouth rinses, ointments, creams or in adhesive vehicles. Several different topical corticosteroids may reduce symptoms and hasten healing of RAS (Cooke and Armitage, 1960; Zegarelli et al , 1960; Merchant et al , 1978; Yeoman et al , 1978; Fisher, 1979; Pimlott and Walker, 1983; Scaglione et al , 1985; Miles et al , 1993). The major concern of possible adrenal suppression with long‐term and/or repeated application has rarely been addressed, although there is evidence that even some of the more potent, such 0.05% fluocinonide in adhesive paste and betamethasone‐17‐valerate mouth rinse do not cause this problem (Porter et al , 2000).…”

Section: Topical Corticosteroidsmentioning

confidence: 99%

Number VI Recurrent aphthous stomatitis

et al. 2005

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Recurrent aphthous stomatitis (RAS; aphthae; canker sores) is a common condition which is characterized by multiple recurrent small, round or ovoid ulcers with circumscribed margins, erythematous haloes, and yellow or grey floors typically presenting first in childhood or adolescence. RAS occurs worldwide although it appears most common in the developed world. The aetiology of RAS is not entirely clear. Despite many studies trying to identify a causal microorganism, RAS does not appear to be infectious. A genetic predisposition is present, as shown by strong associations with genotypes of IL-1beta; IL-6 in RAS patients, and a positive family history in about one-third of patients with RAS. Haematinic deficiency is found in up to 20% of patients. Cessation of smoking may precipitate or exacerbate RAS in some cases. Ulcers similar to RAS may be seen in human immunodeficiency virus disease and some other immune defects, and drugs, especially non-steroidal anti-inflammatory drugs and nicorandil may produce lesions clinically similar to RAS. Topical corticosteroids can often control RAS. However, the treatment of RAS remains unsatisfactory, as most therapies only reduce the severity of the ulceration and do not stop recurrence.

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Section: Topical Corticosteroidsmentioning

confidence: 99%

Number VI Recurrent aphthous stomatitis

et al. 2005

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“…In an attempt to prolong the delivery of drugs in the mouth some dental materials have been considered as carriers and their respective properties reviewed (Douglas, 1977). Short term prolongation has been achieved using adhesive ointments, and the duration of retention of the vehicle at some oral sites was found to be between 1 and 2h (Rothner et al, 1949;Zegarelli et al, 1960). Periodontal dressings have been employed for longer term carriage and release of antibacterial agents to the wound area following gingival surgery (Fraleigh, 1956;Asboe-Jorgensen et al, 1974;Pluss, Engelberge & Rateitschak, 1975;Addy & Douglas, 1975).…”

Section: Introductionmentioning

confidence: 99%

In vitro studies into the use of denture base and soft liner materials as carriers for drugs in the mouth

Addy¹

1981

J of Oral Rehabilitation

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The potential of plasticized and polymerized acrylics to carry and release medicaments was investigated. Chlorhexidine acetate was incorporated at concentrations of 2, 5 and 10% into the powder phase of heat and cold cured acrylics and an acrylic gel soft liner. A preliminary bioassay demonstrated comparable release at anti-bacterial levels from all three materials. Spectrophotometric and agar diffusion measurements of the chlorhexidine released into water showed the duration increased with the concentration of chlorhexidine incorporated. At 10% admixture the release from the polymerized and plasticized acrylics was in excess of 100 days. Light and scanning electron microscopy of polished and fractured surfaces of the polymerized acrylic showed the chlorhexidine distributed throughout the matrix of the materials. Following soaking in water, holes appeared in the matrix, particularly in the surface zones. Sections of the acrylic gel soft liner demonstrated chlorhexidine distributed as particulate material. Soaking in water caused vacuolation of the material and at higher concentrations material break-up was apparent.

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“…A spectrum of different topical corticosteroids can be used (Table 2): All can reduce symptoms, and neither hydrocortisone nor triamcinolone preparations cause adrenal suppression, but ulcers still recur (Cooke and Armitage, 1960;Zegarelli et al, 1960;Merchant et al, 1978;Yeoman et al, 1978;Fisher, 1979;Pimlott and Walker, 1983;Scaglione et al, 1985). Perhaps, at best, topical corticosteroids and chlorhexidine may reduce painful symptoms but not the rate of recurrence of ulcers (Miles et al, 1993).…”

Section: Management (A) Diagnosismentioning

confidence: 99%