Trials of a Fluorescent Endoscopic Video System for Diagnosis and Treatment of the Head and Neck Cancer

Farrakhova, Dina; Shiryaev, Artem; Yakovlev, Dmitry; Efendiev, Kanamat; Maklygina, Yulia; Borodkin, A. V.; Loschenov, M. V.; Bezdetnaya, Lina; Ryabova, Anastasia V.; Amirkhanova, Liana M.; Samoylova, Svetlana I.; Rusakov, M A; Zavodnov, Victor Ya.; Levkin, V.V.; Reshetov, Igor V.; Loschenov, Victor B.

doi:10.3390/jcm8122229

Cited by 9 publications

(5 citation statements)

References 17 publications

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“…The Ce6 antitumor effect also includes damage to both pathological cells by the mechanism of necrosis and/or apoptosis, and tumor-associated macrophages [34,35]. The use of Ce6 during FD and PDT, according to the latest published data, shows high diagnostic and therapeutic efficacy [36][37][38][39][40][41]. Moreover, Ce6 demonstrates higher therapeutic efficacy and fewer side effects compared to hematoporphyrin-based PS [42] Normalization of the fluorescence index was performed by assigning the fluorescence index value of 10 to the DM lining, which allowed to intraoperatively identify areas with increased fluorescence intensity of Ce6 in all three patients.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer

et al. 2022

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Fluorescence diagnostics is one of the promising methods for intraoperative detection of brain tumor boundaries and helps in maximizing the extent of resection. This paper presents the results of a pilot study on the first use of the chlorin e6 photosensitizer and a two-channel video system for fluorescence-guided resection of pituitary adenomas. The study’s clinical part involved two patients diagnosed with hormonally inactive pituitary macroadenomas and one patient with a hormonally active one. All neoplasms had different sizes and growth patterns. The data showed accumulation of chlorin e6 in tumor tissues in high concentrations: Patient 1: 2 mg/kg, Patient 2: 5 mg/kg, and Patient 3: 4 mg/kg. For Patient 1, the residual part of the tumor was not resected since it was intimately attached to the anterior genu of the internal carotid artery. For Patients 2 and 3, no regions of increased Ce6 accumulation were detected in the tumor foci after resection. Therefore, the use of the Ce6 and a two-channel video system helped to achieve a high degree of tumor resection in each case.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer

et al. 2022

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“…Adverse reactions in patients including skin solar sensitivity, pain in the irradiation area, and vocal cord edema and adhesion were reported 223 , 224 . Some studies have shown that sensitizers can also be used for clinical diagnosis and treatment 225 , 226 . PDT is usually used in combination with other therapies in clinic.…”

Section: Clinical Application Against Cancermentioning

confidence: 99%

Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies

Zheng

et al. 2021

Acta Pharmaceutica Sinica B

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Many sensitizers have not only photodynamic effects, but also sonodynamic effects. Therefore, the combination of sonodynamic therapy (SDT) and photodynamic therapy (PDT) using sensitizers for sono-photodynamic therapy (SPDT) provides alternative opportunities for clinical cancer therapy. Although significant advances have been made in synthesizing new sensitizers for SPDT, few of them are successfully applied in clinical settings. The anti-tumor effects of the sensitizers are restricted by the lack of tumor-targeting specificity, incapability in deep intratumoral delivery, and the deteriorating tumor microenvironment. The application of nanotechnology-based drug delivery systems (NDDSs) can solve the above shortcomings, thereby improving the SPDT efficacy. This review summarizes various sensitizers as sono/photosensitizers that can be further used in SPDT, and describes different strategies for enhancing tumor treatment by NDDSs, such as overcoming biological barriers, improving tumor-targeted delivery and intratumoral delivery, providing stimuli-responsive controlled-release characteristics, stimulating anti-tumor immunity, increasing oxygen supply, employing different therapeutic modalities, and combining diagnosis and treatment. The challenges and prospects for further development of intelligent sensitizers and translational NDDSs for SPDT are also discussed.

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“…The results of studies [ 23 , 24 ] have demonstrated the high efficiency of PDT with chlorin e6 (Ce6) for the treatment of cervical neoplasms. Ce6 is a promising PS with significant diagnostic and therapeutic efficacy [ 25 , 26 , 27 , 28 ]. Ce6 is a second-generation PS with high efficiency and minimal dark phototoxicity [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Phototheranostics of Cervical Neoplasms with Chlorin e6 Photosensitizer

Gilyadova

Ищенко

Shiryaev

et al. 2022

Cancers

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(1) Purpose: Improving the treatment effectiveness of intraepithelial neoplasia of the cervix associated with human papillomavirus infection, based on the application of the method of photodynamic therapy with simultaneous laser excitation of fluorescence to clarify the boundaries of cervical neoplasms. (2) Methods: Examination and treatment of 52 patients aged 22 to 53 years with morphologically and cytologically confirmed mild to severe intraepithelial cervix neoplasia, preinvasive, micro-invasive, and squamous cell cervix carcinoma. All patients were carriers of human papillomavirus infection. The patients underwent photodynamic therapy with simultaneous laser excitation of fluorescence. The combined use of video and spectral fluorescence diagnostics for cervical neoplasms made it possible to control the photodynamic therapy process at all stages of the procedure. Evaluation of the photodynamic therapy of intraepithelial cervical neoplasms was carried out with colposcopic examination, cytological conclusion, and morphological verification of the biopsy material after the photodynamic therapy course. The success of human papillomavirus therapy was assessed based on the results of the polymerase chain reaction. (3) Results. The possibility of simultaneous spectral fluorescence diagnostics and photodynamic therapy using a laser source with a wavelength of 660 nm has been established, making it possible to assess the fluorescence index in real-time and control the photobleaching of photosensitizers in the irradiated area. The treatment of all 52 patients was successful after the first photodynamic therapy procedure. According to the PCR test of the discharge from the cervical canal, the previously identified HPV types were not observed in 48 patients. Previously identified HPV types were absent after repeated PDT in four patients (CIN III (n = 2), CIS (n = 2)). In 80.8% of patients, regression of the lesion was noted. (4) Conclusions. The high efficiency of photodynamic therapy with intravenous photosensitizer administration of chlorin e6 has been demonstrated both in relation to eradication therapy of human papillomavirus and in relation to the treatment of intraepithelial lesions of the cervix.

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Trials of a Fluorescent Endoscopic Video System for Diagnosis and Treatment of the Head and Neck Cancer

Cited by 9 publications

References 17 publications

A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer

A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer

Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies

Phototheranostics of Cervical Neoplasms with Chlorin e6 Photosensitizer

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