Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons

Barnes, Lisa L.; Dhana, Klodian; Liu, Xiaoran; Carey, Vincent J.; Ventrelle, Jennifer; Johnson, Kathleen A.; Hollings, Chiquia S.; Bishop, Louise M.; Laranjo, Nancy; Stubbs, Benjamin J.; Reilly, Xavier; Agarwal, Puja; Zhang, Shengwei; Grodstein, Francine; Tangney, Christy; Holland, Thomas; Aggarwal, Neelum T.; Arfanakis, Konstantinos; Morris, Martha Clare; Sacks, Frank M.

doi:10.1056/nejmoa2302368

Cited by 89 publications

(38 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…72 However, a recent RCT showed that the MIND diet failed to show changes in cognitive and brain MRI (WMH, hippocampal volumes, and total gray-and white-matter volumes) outcomes over 3 years among at-risk cognitively unimpaired older adults (ie, family history of AD, overweight, suboptimal diets). 137 The short duration of this trial and caloric restriction in the control group might explain the lack of difference between the randomized arms in this study.…”

Section: Other Lifestyle-related Vascular Risk Factors and Behavioral...mentioning

confidence: 88%

Current and Future Treatments of Vascular Cognitive Impairment

Ip,

Ko,

Lam

et al. 2024

Stroke

View full text Add to dashboard Cite

Nonamyloid sporadic cSVD is considered the most prevalent cause or pathological substrate of VCI. 20,21 It refers to diseased microscopic perforating cerebral arterioles, capillaries, and venules giving rise to abnormalities in the cerebral white and deep gray matter. 5 Driven by arteriosclerosis and fibrinoid necrosis, the arteriolar wall can be stenosed, occluded, dilated, or ruptured, which may result in lacunar infarcts or deep microparenchymal/macroparenchymal hemorrhages. 22 In addition, recent studies suggested that cSVD is a dynamic process that affects the whole brain, beginning at the cellular level that involves the components of neurovascular units, including endothelial cells, pericytes, vascular smooth muscle cells, glia, neurons, immune cells, and extracellular matrix. 23,24 These units regulate cerebral blood flow, endothelial function, BBB integrity, and neuroinflammation. 5,23,25 Endothelial dysfunction, astrocytopathy, and BBB leakage may occur when components of neurovascular units are diseased or damaged due to aging, vascular risk factors (eg, hypertension, hyperlipidemia, hyperhomocysteinemia, diabetes, smoking), 26,27 increase in pulsatile flow being transmitted to the cerebral small vessels secondary to aortic stiffness, 28 and genetic factors. 5,24,29,30 These pathological changes may lead to compromised cerebral

show abstract

Section: Other Lifestyle-related Vascular Risk Factors and Behavioral...mentioning

confidence: 88%

Current and Future Treatments of Vascular Cognitive Impairment

Ip,

Ko,

Lam

et al. 2024

Stroke

View full text Add to dashboard Cite

show abstract

“…Nevertheless, several potentially valuable interventions can be initiated in midlife or later life that may have beneficial effects for individual patients (Table 2). …”

Section: Preventionmentioning

confidence: 99%

Dementia Prevention and Treatment

Reuben,

Kremen,

Maust

2024

JAMA Intern Med

View full text Add to dashboard Cite

ImportanceDementia affects 10% of those 65 years or older and 35% of those 90 years or older, often with profound cognitive, behavioral, and functional consequences. As the baby boomers and subsequent generations age, effective preventive and treatment strategies will assume increasing importance.ObservationsPreventive measures are aimed at modifiable risk factors, many of which have been identified. To date, no randomized clinical trial data conclusively confirm that interventions of any kind can prevent dementia. Nevertheless, addressing risk factors may have other health benefits and should be considered. Alzheimer disease can be treated with cholinesterase inhibitors, memantine, and antiamyloid immunomodulators, with the last modestly slowing cognitive and functional decline in people with mild cognitive impairment or mild dementia due to Alzheimer disease. Cholinesterase inhibitors and memantine may benefit persons with other types of dementia, including dementia with Lewy bodies, Parkinson disease dementia, vascular dementia, and dementia due to traumatic brain injury. Behavioral and psychological symptoms of dementia are best treated with nonpharmacologic management, including identifying and mitigating the underlying causes and individually tailored behavioral approaches. Psychotropic medications have minimal evidence of efficacy for treating these symptoms and are associated with increased mortality and clinically meaningful risks of falls and cognitive decline. Several emerging prevention and treatment strategies hold promise to improve dementia care in the future.Conclusions and RelevanceAlthough current prevention and treatment approaches to dementia have been less than optimally successful, substantial investments in dementia research will undoubtedly provide new answers to reducing the burden of dementia worldwide.

show abstract

“…The MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay)-a hybrid of the MedDiet and the DASH (Dietary Approaches to Stop Hypertension) diet-has been consistently associated with a decreased risk of cognitive decline and dementia in large cohort studies [123]. However, a recent RCT did not find significant effects of the MIND diet intervention on changes in cognition over three years [124]. The relatively short duration of the intervention and similar weight loss between the intervention and control groups might have contributed to the null findings.…”

Section: The Mediterranean Diet (Meddiet) the Traditionalmentioning

confidence: 99%

Diet strategies for promoting healthy aging and longevity: An epidemiological perspective

2023

J Intern Med

View full text Add to dashboard Cite

In recent decades, global life expectancies have risen significantly, accompanied by a marked increase in chronic diseases and population aging. This narrative review aims to summarize recent findings on the dietary factors influencing chronic diseases and longevity, primarily from large cohort studies. First, maintaining a healthy weight throughout life is pivotal for healthy aging and longevity, mirroring the benefits of lifelong, moderate calorie restriction in today's obesogenic food environment. Second, the specific types or food sources of dietary fat, protein, and carbohydrates are more important in influencing chronic disease risk and mortality than their quantity. Third, some traditional diets (e.g., the Mediterranean, Nordic, and Okinawa) and contemporary dietary patterns, such as healthy plant‐based diet index, the DASH (dietary approaches to stop hypertension) diet, and alternate healthy eating index, have been associated with lower mortality and healthy longevity. These patterns share many common components (e.g., a predominance of nutrient‐rich plant foods; limited red and processed meats; culinary herbs and spices prevalent in global cuisines) while embracing distinct elements from different cultures. Fourth, combining a healthy diet with other lifestyle factors could extend disease‐free life expectancies by 8–10 years. While adhering to core principles of healthy diets, it is crucial to adapt dietary recommendations to individual preferences and cultures as well as nutritional needs of aging populations. Public health strategies should aim to create a healthier food environment where nutritious options are readily accessible, especially in public institutions and care facilities for the elderly. Although further mechanistic studies and human trials are needed to better understand molecular effects of diet on aging, there is a pressing need to establish and maintain long‐term cohorts studying diet and aging in culturally diverse populations.

show abstract

Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons

Cited by 89 publications

References 34 publications

Current and Future Treatments of Vascular Cognitive Impairment

Current and Future Treatments of Vascular Cognitive Impairment

Dementia Prevention and Treatment

Diet strategies for promoting healthy aging and longevity: An epidemiological perspective

Contact Info

Product

Resources

About