Trial of Prevention and Reduction of Obesity Through Active Living in Clinical Settings

Ross, Robert; Lam, Miu; Blair, Steven N.; Church, Timothy S.; Godwin, Marshall; Hotz, Stephen B.; Johnson, Ana; Katzmarzyk, Peter T.; Lévesque, Lucie; MacDonald, Susan

doi:10.1001/archinternmed.2011.1972

Cited by 60 publications

(100 citation statements)

References 30 publications

(33 reference statements)

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“…Men comprised 36% of participants in 18 of the trials (4771 from a total of 13,305 participants); in four trials numbers of men recruited were unclear [23][24][25][26]. Eleven trials [23,[26][27][28][29][30][31][32][33][34][35] were conducted in the USA; six [24,25,[36][37][38][39] in Finland and one trial from each of the following locations: Canada [40], Israel [41], Scandinavia [42], Sweden [43,43]and the UK [44].…”

Section: Description Of the Trialsmentioning

confidence: 99%

“…Seven trials [24,25,[31][32][33][34]39] considered low fat reducing diets (LFRDs) either alone or in conjunction with physical activity and/or behavioural therapy. Ross and colleagues [40] examined physical activity and healthy eating advice with behavioural therapy.…”

Section: Description Of the Trialsmentioning

confidence: 99%

“…In total, 13,305 men and women were enrolled in the trials. Where age was reported by sex [25,29,[36][37][38]40,47,48], mean ages ranged from 39 to 62 years for men and 37 to 59 years for women (median 53 years for men and 51 years for women). The highest reported mean BMI for men was 42.7 [36] and 43.6 for women [36], while the lowest was 29.7 [39] and 30.53 [29] respectively.…”

Section: Description Of the Trialsmentioning

confidence: 99%

“…Nine trials [27,29,34,[36][37][38]40,43,44] provided data that could be included in the analysis comparing the number of men and women who completed the trials. The total analysis included 3943 participants, with 1255 men (31.8%) and 2688 women (68.2%) ( Tables 1 and 2).…”

Section: Recruitment and Attrition Of Men And Womenmentioning

confidence: 99%

“…For the analysis comparing mean weight loss between men and women, a total of 13 studies had eligible data [24][25][26][27]29,[31][32][33][34][36][37][38]40]. There were a total of 5890 participants with 2213 (37.6%) men and 3677 (62.4%) women (Figures 1-2).…”

Section: Comparison Of Weight Loss In Men Compared With Women Across mentioning

confidence: 99%

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Should weight loss and maintenance programmes be designed differently for men? A systematic review of long-term randomised controlled trials presenting data for men and women: The ROMEO project

Robertson

Avenell

Boachie

et al. 2016

Obesity Research & Clinical Practice

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KeywordsWeight loss, weight maintenance, men and women, systematic review 3 AcknowledgementsThis review is one of a series of systematic reviews for the ROMEO project (Review Of MEn and Conflict of interestThe authors have no conflict of interests to declare. Contribution of authorsCR drafted the manuscript under the supervision of AA. FS developed and ran the electronic literature search. CR and AA conducted the eligibility screening, data extraction and quality assessment. All authors contributed to the study design and manuscript preparation. 5 AbstractWe systematically reviewed the randomised controlled trial (RCT) evidence for long-term (>12 months) weight management interventions for obese men in contrast to women to help understand whether programmes should be designed differently for men.We searched 11 databases up to October 2014. Twenty-two RCTs reported data separately for men and women in weight loss or weight maintenance interventions.We found men were under-represented in RCTs of weight loss interventions open to both sexes. Men comprised 36% of participants (4771 from 13,305 participants). Despite this, men were 11% (95% CI 8% to 14%, p<0.001) more likely to be trial completers compared to women. The trials did not report service user consultation and none were designed to investigate whether men and women responded differently to given interventions. Our meta-analysis of 13 trials showed no significant difference in weight loss between men and women, either for weight loss in kg ( p=0.90) or percentage weight loss (p=0.78), although men tended to lose more weight with intensive low fat reducing diets, with or without meal replacements, and structured physical activity/exercise programmes than women.Orlistat was less beneficial for men for weight maintenance. Individual support and tailoring appeared more helpful for men than women.We found evidence that men and women respond differently to, and have different preferences for, varying types of weight management programme. We suggest that it is important to understand men's views on weight loss, as this is likely to also improve the uptake and effectiveness of programmes for men.

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Section: Description Of the Trialsmentioning

confidence: 99%

Section: Description Of the Trialsmentioning

confidence: 99%

Section: Description Of the Trialsmentioning

confidence: 99%

Section: Recruitment and Attrition Of Men And Womenmentioning

confidence: 99%

Section: Comparison Of Weight Loss In Men Compared With Women Across mentioning

confidence: 99%

See 3 more Smart Citations

Should weight loss and maintenance programmes be designed differently for men? A systematic review of long-term randomised controlled trials presenting data for men and women: The ROMEO project

Robertson

Avenell

Boachie

et al. 2016

Obesity Research & Clinical Practice

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Behavioral Treatment of Obesity in Patients Encountered in Primary Care Settings

Wadden

Butryn

Hong

et al. 2014

JAMA

236

182

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IMPORTANCE In 2011, the Centers for Medicare and Medicaid Services (CMS) approved intensive behavioral weight loss counseling (i.e., approximately 14, 10–15 minute, face-to-face sessions in 6 months) for obese beneficiaries in primary care settings, when delivered by physicians and other CMS-defined primary care practitioners (PCPs). OBJECTIVE To conduct a systematic review of behavioral counseling for overweight/obese patients recruited from primary care, as delivered by PCPs working alone or with trained interventionists (e.g., medical assistants, registered dietitians), or by trained interventionists working independently. EVIDENCE REVIEW We searched PubMed, CINAHL, and EMBASE for randomized controlled trials (January 1980–June 2014) which: recruited overweight/obese patients from primary care; provided behavioral counseling (i.e., diet, exercise, and behavior therapy) for ≥3 months, with ≥6 months post-randomization follow-up; included ≥15 participants/treatment group and objectively measured weights; and had a comparator, an intention-to-treat analysis, and attrition <30% at 1 year or <40% at longer follow-up. FINDINGS Review of 3,304 abstracts yielded 12 trials (with 3,893 total participants) that met inclusion/exclusion criteria and pre-specified quality ratings. No studies were found in which PCPs delivered counseling following CMS guidelines (14 sessions in 6 months). Mean 6-month weight changes (relative to baseline) in the intervention group ranged from −0.3 to −6.6 kg, with corresponding values of +0.9 to −2.0 kg in control group. Weight loss in both groups generally declined with longer follow-up (12–24 months). Interventions that prescribed both reduced energy intake (e.g., ≥500 kcal/day deficit) and increased physical activity (e.g., ≥150 minutes/week of walking), with traditional behavior therapy, generally produced larger weight loss than interventions without all three specific components. In the former trials, more treatment sessions, delivered in person or by phone by trained interventionists, were associated with greater mean weight loss and likelihood of losing ≥5% of baseline weight. CONCLUSIONS AND RELEVANCE Intensive behavioral counseling can induce clinically meaningful weight loss, but there is little research on PCPs providing such care. The present findings suggest that a range of trained interventionists, who deliver counseling in person or by telephone, could be considered in treating overweight/obesity in patients encountered in primary care.

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Behavioral and Pharmacotherapy Weight Loss Interventions to Prevent Obesity-Related Morbidity and Mortality in Adults

LeBlanc

Patnode

Webber

et al. 2018

JAMA

354

328

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Trial of Prevention and Reduction of Obesity Through Active Living in Clinical Settings

Abstract: clinicaltrials.gov Identifier: NCT00665158.

Cited by 60 publications

References 30 publications

Should weight loss and maintenance programmes be designed differently for men? A systematic review of long-term randomised controlled trials presenting data for men and women: The ROMEO project

Should weight loss and maintenance programmes be designed differently for men? A systematic review of long-term randomised controlled trials presenting data for men and women: The ROMEO project

Behavioral Treatment of Obesity in Patients Encountered in Primary Care Settings

Behavioral and Pharmacotherapy Weight Loss Interventions to Prevent Obesity-Related Morbidity and Mortality in Adults

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