Trial of a Cinchoninic Acid Derivative in Some Collagen Diseases

Treatment of Gout with H.P.C

“…in cases of acute rheumatic fever, chronic rheumatoid arthritis, and disseminated lupus erythematosus. In this country Rennie et al (1951) found the drug of value in a small group of cases of rheumatic fever and scleroderma. This preliminary report suggested that a further investigation was justifiable, and in the summer of 1951 a small supply of H.P.C.…”

Effect of Pituitary Stalk Section on the Development of Cinchophen Ulcer in the Canine Stomach with Special Reference to the Hypothalamo-Neurohypophyseal System and Adrenal Gland

“…Although the mechanism involved in its development has not been elucidated, its importance is well recognizable, since the main problem of the experimental investigators in this field has been to produce a chronic type of lesions if his efforts were to result in producing an ulceration that would simulate the lesions in the human. Cinchophen is a drug widely used in the treatment of rheumatism, arthritis and gout, and its derivative i. e. 3-hydroxy-2•phenol-cinchoninic acid is also therapeutic effective for collagen disease (10). This compound, like the former, exerts adrenocortical stimulation and, in addition, antidiuretic effect (11).…”

The Synthesis of 3-Hydroxycinchoninic Acid and Certain of Its Derivatives

“…

3-Hydroxy-2-phenylcinchoninic acid (HPC) and certain of its derivatives exhibit a number of interesting pharmacological properties (2,3,4,6,7,(10)(11)(12)(13)18,23,24,26, 27). Blanchard, et al (3) have shown that the 2-phenyl group is COOH -<A|/\oh OU-o not essential for activity and have reported that 3-hydroxycinchoninic acid (I) is as active pharmacologically as HPC and that it is less toxic.

…”