Triadimenol promotes the production of reactive oxygen species and apoptosis with cardiotoxicity and developmental abnormalities in zebrafish

Park, Junho; Hong, Taeyeon; An, Garam; Park, Hahyun; Song, Gwonhwa; Lim, Whasun

doi:10.1016/j.scitotenv.2022.160761

Cited by 20 publications

(5 citation statements)

References 85 publications

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“…However, QUE-NCs at all concentrations showed no significant effect on the yolk sac volume of zebrafish embryos compared to the control group (Figure 3F). Zebrafish incubated with NCs at a high concentration of 265 µg/mL exhibited constraints in both heart rate and body length, consistent with other reported toxicities of drugs on zebrafish (Due to high lethality and deformity rates, the zebrafish exposed to a concentration of 530 µg/mL were not studied) [44]. In contrast, zebrafish cultured at a concentration of 53 µg/mL showed minimal effects on survival rate, heart rate, and body length, making it suitable for subsequent antioxidant assays.…”

Section: Effects Of Que-ncs In Zebrafish In Vivo 251 Toxicity Of Que-...supporting

confidence: 85%

Antioxidant Effects of Quercetin Nanocrystals in Nanosuspension against Hydrogen Peroxide-Induced Oxidative Stress in a Zebrafish Model

Wang,

Xue,

Miao

2023

Pharmaceuticals

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Quercetin, a flavonoid compound rich in hydroxyl groups, possesses antioxidant properties, whereas its poor water solubility limits its bioavailability. In pursuit of addressing the water solubility of quercetin and comprehending the impact of nanocrystal particle size on antioxidant efficacy, we prepared three different-sized quercetin nanocrystals, namely small (50 nm), medium (140 nm), and large (360 nm), using a nanosuspension method in this study. Within the in vitro setting, assessments employing solubility and radical scavenging assays revealed that quercetin nanocrystals displayed superior solubility (26, 21, and 13 fold corresponding to small, medium, and large particle sizes) and antioxidant performance compared to the coarse quercetin. Furthermore, quercetin nanocrystals of three particle sizes all demonstrated significant protection effects on the survival rate of H2O2-treated zebrafish at 72 h (77.78%, 73.33%, and 66.67% for small, medium, and large particle sizes, respectively), while the coarse quercetin group exhibited a low survival rate (53.3%) similar to the H2O2-treated group (47.8%). Moreover, all quercetin nanocrystals exhibited potent antioxidant capacity on both the antioxidants and enzymatic antioxidant system in H2O2-treated zebrafish to restore zebrafish to a normal state under oxidative stress. For instance, the levels of reactive oxygen species were reduced to 101.10%, 108.83%, and 109.77% of the normal levels for small, medium, and large particle-sized quercetin nanocrystals, respectively. In conclusion, quercetin nanocrystals demonstrated enhanced solubility, robust antioxidant capacity, and protective effects in zebrafish compared to coarse quercetin.

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Section: Effects Of Que-ncs In Zebrafish In Vivo 251 Toxicity Of Que-...supporting

confidence: 85%

Antioxidant Effects of Quercetin Nanocrystals in Nanosuspension against Hydrogen Peroxide-Induced Oxidative Stress in a Zebrafish Model

Wang,

Xue,

Miao

2023

Pharmaceuticals

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“…As one kind of triazole fungicide, difenoconazole has been reported to induce DNA damage and apoptosis of non-target organisms. The impacts were associated with ROS production (Jiang et al, 2020;Park et al, 2022;Teng et al, 2018). Besides, residual difenoconazole depressed the dry weight of soil fauna.…”

Section: Difenoconazole Influenced the Physiological Activity Of E Cr...mentioning

confidence: 99%

Understanding the ecological effects of the fungicide difenoconazole on soil and Enchytraeus crypticus gut microbiome

Qin

Zhang

et al. 2023

Environmental Pollution

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“…Agonists for the Vdr (calcitriol) or Rar (retinoic acid) were used as reference compounds and their chemical similarities were computed to all compounds in the POP mix. In addition, 4 triazole fungicides with a potential to be endocrine disruptors and posing serious concerns were chosen to complete the analysis: flusilazole, triadimenol, diniconazole and hexaconazole [52][53][54][55][56][57][58][59]. Hierarchical agglomerative nesting clustering was performed using the chemical fingerprints (toxprints) of all these compounds (Fig 7).…”

Section: Chemical Similarities Between Pops and Retinoids Or Vitamin Dmentioning

confidence: 99%

A realistic mixture of ubiquitous persistent organic pollutants affects bone and cartilage development in zebrafish by interaction with nuclear receptor signaling

Guerrero-Limón,

Zappia,

Muller

2024

PLoS ONE

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"Persistent organic pollutants (POPs)" have a plethora of deleterious effects on humans and the environment due to their bioaccumulative, persistent, and mimicking properties. Individually, each of these chemicals has been tested and its effects measured, however they are rather found as parts of complex mixtures of which we do not fully grasp the extent of their potential consequences. Here we studied the effects of realistic, environmentally relevant mixtures of 29 POPs on cartilage and bone development using zebrafish as a model species. We observed developmental issues in cartilage, in the form of diverse malformations such as micrognathia, reduced size of the Meckel’s and other structures. Also, mineralized bone formation was disrupted, hence impacting the overall development of the larvae at later life stages. Assessment of the transcriptome revealed disruption of nuclear receptor pathways, such as androgen, vitamin D, and retinoic acid, that may explain the mechanisms of action of the compounds within the tested mixtures. In addition, clustering of the compounds using their chemical signatures revealed structural similarities with the model chemicals vitamin D and retinoic acid that can explain the effects and/or enhancing the phenotypes we witnessed. Further mechanistic studies will be required to fully understand this kind of molecular interactions and their repercussions in organisms. Our results contribute to the already existing catalogue of deleterious effects caused by exposure to POPs and help to understand the potential consequences in at risk populations.

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Triadimenol promotes the production of reactive oxygen species and apoptosis with cardiotoxicity and developmental abnormalities in zebrafish

Cited by 20 publications

References 85 publications

Antioxidant Effects of Quercetin Nanocrystals in Nanosuspension against Hydrogen Peroxide-Induced Oxidative Stress in a Zebrafish Model

Antioxidant Effects of Quercetin Nanocrystals in Nanosuspension against Hydrogen Peroxide-Induced Oxidative Stress in a Zebrafish Model

Understanding the ecological effects of the fungicide difenoconazole on soil and Enchytraeus crypticus gut microbiome

A realistic mixture of ubiquitous persistent organic pollutants affects bone and cartilage development in zebrafish by interaction with nuclear receptor signaling

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