Triad of visual, auditory and corticospinal tract lesions: a new syndrome in a patient with HIV infection

Kleffner, Ilka; Wersching, Heike; Schwindt, Wolfram; Keyvani, Kathy; Deppe, Michael; Husstedt, Ingo W.

doi:10.1097/qad.0b013e328342fc05

Cited by 5 publications

(3 citation statements)

References 8 publications

(9 reference statements)

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“…Moreover, it appears that the latter disease may be reversible with the introduction of ART (28,30) . Based on these statements, it can be concluded that the use of ART, along with speech therapy intervention, may benefit patients by increasing the quality of life indices and reducing the morbidity and mortality of the AIDS population.…”

Section: Discussionmentioning

confidence: 99%

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Atuação fonoaudiológica em pacientes com síndrome da imunodeficiência adquirida e queixa de deglutição – análise retrospectiva de prontuários

Mangilli

Sassi

Stafocher

et al. 2016

Audiol., Commun. Res.

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Purpose: To verify and characterize the function of swallowing in Acquired Immunodeficiency Syndrome (AIDS) patients with a complaint of dysphagia. Methods: We performed a retrospective analysis of the medical records of 17 AIDS patients treated in a school hospital between 2011 and 2012, who underwent a bedside evaluation and treatment of swallowing. The data were related to the results of the bedside evaluation that followed specific protocols, both at baseline and discharge. Patients were divided into two groups: 1) patients who completed the swallowing intervention during the admission (GCSI); and 2) patients who did not complete the swallowing intervention during the admission (GNCSI). Results: The groups did not differ in age and gender. For the classification of swallowing: 1) both groups had significantly better scores at discharge compared to those at baseline (GNCSI: p=0.024; GCSI: p=0.011); 2) the scores did not differ between groups at baseline (p=0.349); 3) at discharge, the scores were different between groups (p=0.002), with better results in the GCSI group. The analysis of the clinical signs and symptoms of oropharyngeal dysphagia or penetration/ aspiration indicated that in both groups, there was a statistically significant difference between baseline and discharge only in the presence of multiple swallows (a decrease in the number of swallows after intervention). Conclusion: Swallowing ability improved after intervention. Additionally, clinical signs and symptoms suggestive of oropharyngeal dysphagia or penetration/aspiration resolved. The GCSI group showed better results than GNCSI after intervention.Keywords: Deglutition; Deglutition disorders; Acquired Immunodeficiency Syndrome; Speech, Language and Hearing Sciences; Evaluation RESUMO Objetivo: Verificar e caracterizar a deglutição de pacientes internados, diagnosticados com Síndrome da Imunodeficiência Adquirida (SIDA), com queixas de deglutição. Métodos: Análise retrospectiva de 17 prontuários de pacientes com SIDA, atendidos em um hospital escola, entre 2011 e 2012, submetidos a protocolos de avaliação e tratamento da deglutição em beira de leito. Os dados coletados foram referentes à avaliação da deglutição em beira de leito, por meio de protocolos específicos, no momento inicial e na alta fonoaudiológica ou hospitalar. Os pacientes foram divididos em dois grupos: Grupo de alta fonoaudiológica (GAF): pacientes que receberam alta fonoaudiológica antes da alta hospitalar; Grupo de alta hospitalar (GAH): pacientes que receberam alta hospitalar sem terem recebido alta fonoaudiológica. Resultados: Os grupos não se diferenciaram em relação à idade e gênero. Quanto à classificação da disfagia: 1) ambos os grupos apresentaram escores significativamente melhores no momento da alta, em relação ao momento inicial (GAH -p=0,024; GAF -p=0,011); 2) os grupos não se diferenciaram no momento inicial (p=0,349); 3) no momento de alta, os grupos apresentaram diferença significativa (p=0,002), com melhores resultados para o GAF. A análise dos sinais...

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Section: Discussionmentioning

confidence: 99%

“…Researchers have indicated that, lesions on the cortical tracts were not associated with AIDS, although isolated motor neuron diseases have previously been described (28)(29)(30) . Moreover, it appears that the latter disease may be reversible with the introduction of ART (28,30) .…”

Section: Discussionmentioning

confidence: 99%

Atuação fonoaudiológica em pacientes com síndrome da imunodeficiência adquirida e queixa de deglutição – análise retrospectiva de prontuários

Mangilli

Sassi

Stafocher

et al. 2016

Audiol., Commun. Res.

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“…89 In a case involving multiple sensory pathways, a patient with early HIV infection (CD4 + count of 720) was found to have progressive degeneration of the visual, auditory and corticospinal tracts. 90 …”

Section: Neuro-ophthalmologic Findingsmentioning

confidence: 99%

Human immunodeficiency virus and its effects on the visual system

Stewart

2012

Infect Dis Rep

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Treatment of immigrants and residents suffering from Neuro-Aids on a neurological intensive care unit: epidemiology and predictors of outcome

et al. 2013

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This study aimed at determining the clinical features and predictors for the outcome of patients with Neuro-Aids treated on a neurological intensive care unit (NICU) using retrospective analysis of all patients treated for Neuro-Aids in a tertiary Department of Neurology between 1996 and 2011. Chart review of the patients including the characteristics of intensive care was performed. As negative outcome, "death on the NICU or within 2 months following completion of NICU treatment" was defined. In total, 462 patients were identified of whom 87 were immigrants. 67 of all patients required NICU treatment (mean age 40.2 ± 0.8 years; 64% male). The median of the duration between diagnosis of HIV infection and the onset of treatment on NICU was 8 days for immigrants and 10 years for residents (p < 0.001). 34 of the patients on the NICU died due to severe neuromanifestations. Negative predictors for death were: (1) artificial ventilation; (2) antiretroviral-naïve immigrant; (3) primary cerebral lymphoma; (4) missing antiretroviral therapy upon admission to the NICU. Gender, age, ethnicity, CD4+ cell count, and viral load were no predictors of a negative outcome. The results indicated that the rate of death during treatment on a NICU is much higher as compared with treatment on an internal medicine ICU. A lot of research and effort will be necessary to improve this outcome especially for immigrants with Neuro-Aids.

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Triad of visual, auditory and corticospinal tract lesions: a new syndrome in a patient with HIV infection

Abstract: The triad of auditory, visual and corticospinal lesions has been described in rare syndromes and hereditary diseases. This is the first case of this syndrome associated with a HIV infection.

Cited by 5 publications

References 8 publications

Atuação fonoaudiológica em pacientes com síndrome da imunodeficiência adquirida e queixa de deglutição – análise retrospectiva de prontuários

Atuação fonoaudiológica em pacientes com síndrome da imunodeficiência adquirida e queixa de deglutição – análise retrospectiva de prontuários

Human immunodeficiency virus and its effects on the visual system

Treatment of immigrants and residents suffering from Neuro-Aids on a neurological intensive care unit: epidemiology and predictors of outcome

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