Tri-ortho-cresyl phosphate induces autophagy of mouse ovarian granulosa cells

Wang, Jinglei; Ruan, Wenli; Huang, Boshu; Shao, Shuxin; Yang, Dan; Liu, Mengling; Zeng, Lin; Wei, Jie; Chen, Jiaxiang

doi:10.1530/rep-18-0456

Cited by 18 publications

(12 citation statements)

References 30 publications

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“…We also found that TOCP could induce autophagy of mouse spermatogonial stem cells and mouse Leydig TM3 cells . In the present study, we found that TOCP exposure induced autophagic cell death of mouse ovarian granulosa cells, which was in accordance with our previous results . The SQSTM1/p62 protein serves as a link between LC3 and ubiquitinated substrates.…”

Section: Discussionsupporting

confidence: 93%

“…We also discovered that TOCP could reduce sperm density in epididymis and inhibit viability of spermatogonial stem cells in mice and even inhibit viability of mouse Leydig TM3 cells . TOCP has also been reported to cause ovarian failure and decrease serum estradiol concentration . One of the important function of ovarian granulosa cells is to synthesize and secrete estradiol, which indicates that TOCP could cause ovarian granulosa cells damage.…”

Section: Discussionmentioning

confidence: 87%

“…10 TOCP has also been reported to cause ovarian failure and decrease serum estradiol concentration. 11,12 One of the important function of ovarian granulosa cells is to synthesize and secrete estradiol, which indicates that TOCP could cause ovarian granulosa cells damage.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from the neurotoxicity, immunotoxicity, and liver toxicity, TOCP can also cause severe damage to mouse male reproductive system irreversibly, in which TOCP exposure decreases the sperm density in the epididymis and inhibits viability of spermatogonial stem cells and mouse Leydig TM3 cells . TOCP is also shown to cause ovarian failure . However, it is still unknown about the potential mechanism.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 TOCP is also shown to cause ovarian failure. 11,12 However, it is still unknown about the potential mechanism.…”

Section: Introductionmentioning

confidence: 99%

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Tea polyphenols alleviate tri‐ortho‐cresyl phosphate‐induced autophagy of mouse ovarian granulosa cells

Yang

Shao

Huang

et al. 2019

Environmental Toxicology

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Tri‐ortho‐cresyl phosphate (TOCP), a widely used plasticizer in industry, can cause female reproductive damage. Tea polyphenols (TPs) have multiple health effects via inhibiting oxidative stress. However, the reproductive protection of TPs in TOCP‐induced female reproductive system damage is yet to be elucidated. In the study, TOCP inhibited cell viability and induced autophagy of mouse ovarian granulosa cells; while TPs could rescue the inhibition of viability and induction of autophagy. 3‐MA, an autophagy inhibitor, could also rescue the inhibition of cell viability. These results indicated that TPs played a protective role in TOCP‐induced autophagy. Furthermore, TPs could inhibit the induction of oxidative stress of the cells by TOCP, which implying that TPs might alleviate TOCP‐induced autophagy via inhibiting oxidative stress. Furthermore, TPs could rescue TOCP‐induced autophagy and oxidative stress in the mouse ovarian tissues. Taken together, these results indicated that TPs could protect TOCP‐induced ovarian damage via inhibiting oxidative stress.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…9,10 TOCP is also shown to cause ovarian failure. 11,12 However, it is still unknown about the potential mechanism.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Tea polyphenols alleviate tri‐ortho‐cresyl phosphate‐induced autophagy of mouse ovarian granulosa cells

Yang

Shao

Huang

et al. 2019

Environmental Toxicology

Self Cite

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The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes

Land

Miller

Fugate

et al. 2022

Molecular Reproduction Devel

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Exposure to endocrine‐disrupting chemicals (EDCs) is unavoidable, which represents a public health concern given the ability of EDCs to target the ovary. However, there is a large gap in the knowledge about the impact of EDCs on ovarian function, including the process of ovulation. Defects in ovulation are the leading cause of infertility in women, and EDC exposures are contributing to the prevalence of infertility. Thus, investigating the effects of EDCs on the ovary and ovulation is an emerging area for research and is the focus of this review. The effects of EDCs on gametogenesis, uterine function, embryonic development, and other aspects of fertility are not addressed to focus on ovarian‐ and ovulation‐related fertility issues. Herein, findings from epidemiological and basic science studies are summarized for several EDCs, including phthalates, bisphenols, per‐ and poly‐fluoroalkyl substances, flame retardants, parabens, and triclosan. Epidemiological literature suggests that exposure is associated with impaired fecundity and in vitro fertilization outcomes (decreased egg yield, pregnancies, and births), while basic science literature reports altered ovarian follicle and corpora lutea numbers, altered hormone levels, and impaired ovulatory processes. Future directions include identification of the mechanisms by which EDCs disrupt ovulation leading to infertility, especially in women.

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Di‐2‐ethylhexyl phthalate (DEHP) induces apoptosis and autophagy of mouse GC‐1 spg cells

Gan

Yang

et al. 2019

Environmental Toxicology

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As a widely used plasticizer in industry, di‐2‐ethylhexylphthalate (DEHP) can cause testicular toxicity, yet little is known about the potential mechanism. In this study, DEHP exposure dramatically inhibited cellviability and induced apoptosis of mouse GC‐1 spg cells. Furthermore, DEHP significantly increased the levels of autophagy proteins LC3‐II, Beclin1 and Atg5, as well as the ratio ofLC3‐II/LC3‐I. Transmission electron microscopy (TEM) further confirmed that DEHP induced autophagy of mouse GC‐1 spg cells. DEHP was also shown to induceoxidative stress; while inhibition of oxidative stress with NAC could increase cell viability and inhibit DEHP‐induced apoptosis and autophagy. These results suggested that DEHP induced apoptosis and autophagy of mouse GC‐1 spg cells via oxidative stress. 3‐MA, an inhibitor of autophagy, could rescue DEHP‐induced apoptosis. In summary, DEHP induced apoptosis and autophagy of mouse GC‐1 spg cells via oxidative stress, and autophagy might exert a cytotoxic effect on DEHP‐induced apoptosis.

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Tri-ortho-cresyl phosphate induces autophagy of mouse ovarian granulosa cells

Cited by 18 publications

References 30 publications

Tea polyphenols alleviate tri‐ortho‐cresyl phosphate‐induced autophagy of mouse ovarian granulosa cells

Tea polyphenols alleviate tri‐ortho‐cresyl phosphate‐induced autophagy of mouse ovarian granulosa cells

The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes

Di‐2‐ethylhexyl phthalate (DEHP) induces apoptosis and autophagy of mouse GC‐1 spg cells

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