TRH Tests in a Healthy Elderly Population

Targum, Steven D.; Marshall, Lois E.; Magac‐Harris, Kelly; Martin, David

doi:10.1111/j.1532-5415.1989.tb05685.x

Cited by 16 publications

(1 citation statement)

References 15 publications

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“…Interestingly, the response to TRH was similarly reduced in all elderly subjects, we did not find significant gender differences in basal and TRH-stimulated levels. Targum et al [26] reported a significant reduction of TSH re sponse to TRH in men only, and Jacques et al [25] found significant differences with respect to controls in both sexes, though males showed a lower response. In these studies, however, screening for thyroid antibodies was not conducted and a 'conventional' TSH assay was used.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Modifications in the Regulation of the Hypothalamic-Pituitary-Thyroid Axis

Monzani¹,

Guerra²,

Caraccio³

et al. 1996

Horm Res

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We studied the hypothalamic-pituitary-thyroid function in two groups of healthy elderly subjects: group A (n = 23, age range 65-80 years), and group B (n = 11 age range 81-92 years), and in 32 controls, aged 20-60. A TRH test for TSH and prolactin was performed in all subjects, while the TSH circadian modulation was evaluated in elderly subjects only. Group B showed significantly lower fT₃ and TSH, and higher fT₄ levels with respect to controls (fT₃: 4.4 ± 0.2 vs. 5.2 ± 0.2 pmol/l, p < 0.05; fT₄: 13.1 ± 0.9 vs. 11.4 ± 0.4 pmol/l, p < 0.05; TSH: 1.07 ± 0.21 vs. 1.46 ± 0.13 mIU/1, p < 0.05). Morning TSH showed an inverse correlation with age (r = -0.42; p < 0.02) among the 34 elderly subjects, but not among controls. Evidence for TSH circadian modulation was found only in group A (nighttime TSH: 1.60 ± 0.17, vs. daytime: 1.25 ± 0.13 mIU/1, p < 0.001). The TRH-stimulated TSH peak was reduced among all elderly subjects with respect to controls (A: 6.26 ± 0.64 mIU/1, p = 0.01; B: 5.02 ± 0.58 mIU/1, p < 0.01). The maximal PRL response was also blunted (A: 25.7 ± 2.6 μg/l, B: 27.7 ± 5.2 μg/l, p < 0.0005). In conclusion, a resetting of the pituitary threshold of the TSH feedback suppression, along with complex alterations in peripheral thyroid hormone levels, may progressively develop in older people, becoming apparent only with extreme senescence. Moreover, the TSH nocturnal surge may be lost with increasing age, thus providing evidence also for hypothalamic dysfunction.

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Section: Discussionmentioning

confidence: 99%

Age-Related Modifications in the Regulation of the Hypothalamic-Pituitary-Thyroid Axis

Monzani¹,

Guerra²,

Caraccio³

et al. 1996

Horm Res

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Sex and Gender Differences in Endocrinology

Kautzky‐Willer

2011

Sex and Gender Aspects in Clinical Medicine

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Gender differences in TRH-stimulated TSH and prolactin in primary degenerative dementia and elderly controls

Dysken

Falk

Pew

et al. 1990

Biological Psychiatry

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We performed thyrotropin-releasing hormone (TRH) stimulation testing in 18 nondepressed patients with primary degenerative dementia (10 M, 8F; average age +/- SD = 68 +/- 7) and 12 elderly controls (7M, 5F; average age +/- SD = 61 +/- 6). Six patients were retested approximately 2 years later. Initial Mini-Mental State Examination scores for patients ranged from 2 to 28 (average +/- SD = 18 +/- 6) and the scores for the control subjects were all equal to 30. Protirelin (500 micrograms) was injected iv and blood was sampled at 0, 15, 30, 45, 60, and 90 min for thyrotropin-stimulating hormone (TSH) and prolactin (PRL). There were no significant differences between patients and controls in baseline T4, T3 uptake, TSH, or PRL. No significant differences were found between patients and controls for either TRH-stimulated TSH or PRL at all time points. Duration of illness, severity of dementia, and severity of depressive symptoms did not correlate significantly with stimulation test results. There were, however, significantly greater responses in stimulated TSH and PRL for women compared with men in both patients and controls. Upon repeat testing (n = 6), TRH-stimulated TSH and PRL were not significantly different from the initial results.

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TRH Tests in a Healthy Elderly Population

Cited by 16 publications

References 15 publications

Age-Related Modifications in the Regulation of the Hypothalamic-Pituitary-Thyroid Axis

Age-Related Modifications in the Regulation of the Hypothalamic-Pituitary-Thyroid Axis

Sex and Gender Differences in Endocrinology

Gender differences in TRH-stimulated TSH and prolactin in primary degenerative dementia and elderly controls

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