TRH receptor on immune cells:In vitro andin Vivo stimulation of human lymphocyte and rat splenocyte DNA synthesis by TRH

Raiden, Silvina; Polack, Edith; Nahmod, Víctor E.; Labeur, Marta; Holsboer, Florian; Arzt, Eduardo

doi:10.1007/bf01540881

Cited by 27 publications

(20 citation statements)

References 41 publications

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“…Furthermore, TRHR expression in organs and cells of the immune system has been confirmed: Expression of TRHR mRNA and TRHR in lymphoid tissues has been found: Thymus, mesenteric lymph nodes and spleen (Raiden et al, 1995; Mellado et al, 1999). …”

Section: Thyrotropin-releasing Hormone (Trh)mentioning

confidence: 93%

“…Expression of TRHR mRNA and TRHR in lymphoid tissues has been found: Thymus, mesenteric lymph nodes and spleen (Raiden et al, 1995; Mellado et al, 1999). …”

Section: Thyrotropin-releasing Hormone (Trh)mentioning

confidence: 99%

“…Analysis of human peripheral blood lymphocyte (Raiden et al, 1995; Mellado et al, 1999) and tonsil-derived leukocyte populations showed TRHR expression in non-activated and phytohemagglutinin-activated T and B cells (Mellado et al, 1999). …”

Section: Thyrotropin-releasing Hormone (Trh)mentioning

confidence: 99%

“…Acute and chronic administration of TRH enhances the proliferation of splenic and thymic lymphocytes in rats (Pawlikowski et al, 1992; Raiden et al, 1995; Winczyk and Pawlikowski, 2000). In fact, it has been reported that TRH promotes thymic reconstitution in mice with anterior hypothalamic area lesions (Lesnikov et al, 1991).…”

Section: Thyrotropin-releasing Hormone (Trh)mentioning

confidence: 99%

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Hypothalamic neurohormones and immune responses

Quintanar¹,

Guzmán-Soto²

2013

Front. Integr. Neurosci.

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The aim of this review is to provide a comprehensive examination of the current literature describing the neural-immune interactions, with emphasis on the most recent findings of the effects of neurohormones on immune system. Particularly, the role of hypothalamic hormones such as Thyrotropin-releasing hormone (TRH), Corticotropin-releasing hormone (CRH) and Gonadotropin-releasing hormone (GnRH). In the past few years, interest has been raised in extrapituitary actions of these neurohormones due to their receptors have been found in many non-pituitary tissues. Also, the receptors are present in immune cells, suggesting an autocrine or paracrine role within the immune system. In general, these neurohormones have been reported to exert immunomodulatory effects on cell proliferation, immune mediators release and cell function. The implications of these findings in understanding the network of hypothalamic neuropeptides and immune system are discussed.

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Section: Thyrotropin-releasing Hormone (Trh)mentioning

confidence: 93%

“…Expression of TRHR mRNA and TRHR in lymphoid tissues has been found: Thymus, mesenteric lymph nodes and spleen (Raiden et al, 1995; Mellado et al, 1999). …”

Section: Thyrotropin-releasing Hormone (Trh)mentioning

confidence: 99%

Section: Thyrotropin-releasing Hormone (Trh)mentioning

confidence: 99%

Section: Thyrotropin-releasing Hormone (Trh)mentioning

confidence: 99%

See 2 more Smart Citations

Hypothalamic neurohormones and immune responses

Quintanar¹,

Guzmán-Soto²

2013

Front. Integr. Neurosci.

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“…Yet, evidence exists indicating that TRH and TSH can directly or indirectly influence peripheral immunity in a number of ways. For example, TRH has been reported to have costimulatory effects on mitogen-induced lymphocyte responses of rat spleen cells (10), and TSH has been shown to augment Agspecific spleen plaque-forming cell responses in mice (11)(12)(13). Those apparent effects may be indirect, however, as inferred from studies demonstrating TSH binding to monocytic cells (14).…”

mentioning

confidence: 99%

The Thyrotropin (Thyroid-Stimulating Hormone) Receptor Is Expressed on Murine Dendritic Cells and on a Subset of CD45RBhigh Lymph Node T Cells: Functional Role for Thyroid-Stimulating Hormone During Immune Activation

Bagriacik

Klein

2000

The Journal of Immunology

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Thyroid-stimulating hormone (TSH), a central neuroendocrine mediator of the hypothalamus-pituitary-thyroid axis, has been shown to affect various aspects of immunological development and function. To gain a better understanding of TSH involvement within the mammalian immune system, the expression and distribution of the TSH receptor (TSHr) has been studied by immunoprecipitation and by flow cytometric analyses. Using highly enriched populations of B cells, T cells, and dendritic cells, trace amounts of TSHr were precipitated from B cells and T cells, whereas high levels of TSHr were precipitated from the dendritic cell fraction. Flow cytometric analyses of TSHr expression on splenic and lymph node T cells revealed a major difference between those tissues in that only 2–3% of splenic T cells were TSHr+, whereas 10–20% of CD4+8− and CD4−8+ lymph node T cells expressed the TSHr, which was exclusively associated with CD45RBhigh cells and was not expressed during or after activation. The TSHr was not present on cells of the immune system during fetal or neonatal life. However, recombinant TSHβ was found to significantly enhance the phagocytic activity of dendritic cells from adult animals and to selectively augment IL-1β and IL-12 cytokine responses of dendritic cells following phagocytic activation. These findings identify a novel immune-endocrine bridge associated with professional APCs and naive T cells.

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