TRH and TRH receptor system in the basolateral amygdala mediate stress-induced depression-like behaviors

Choi, Jungwon; Kim, Ji Eun; Kim, Tae Kyung; Park, Jin Young; Lee, Jung Eun; Kim, Hannah; Lee, Eun Hwa; Han, Pyung Lim

doi:10.1016/j.neuropharm.2015.03.030

Cited by 38 publications

(51 citation statements)

References 66 publications

(67 reference statements)

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“…Considering these results together, we speculate that the weakly increased base-line c-Fos levels in Veh-injection controls might be attributed to the stimulation of BLA neurons by a needle injection and/or vehicle (0.9% saline) infusion. However, considering that Veh-injection in the BLA did not induce behavioral changes in various tests [213233]. We speculate that weakly increased c-Fos levels in Veh-injection controls present non-specific activation of BLA neurons and therefore, they do not likely lead to behavioral changes.…”

Section: Discussionmentioning

confidence: 91%

“…Chronic stress in rodents produces sociability deficits, increased anxiety and depressive behaviors, whereas exercise produces opposing effects on these behavioral changes [21223839]. Recently, we demonstrated that these stress-induced sociability impairments and depression-related behaviors, and exercise-induced counteractive effects on these behavioral changes all could be experimentally shifted to an opposite direction when BLA activity was blocked [213233]. These results support the notion that the BLA functions as a critical neuroanatomical node integrating various types of emotion-related information and regulating mood-related behaviors.…”

Section: Discussionmentioning

confidence: 99%

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Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors

Kim

Han

2016

Exp Neurobiol

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Chronic stress induces changes in neuronal functions in specific brain regions regulating sociability and mood-related behaviors. Recently we reported that stress-induced persistent upregulation of the neuropeptides orexin and melanin-concentrating hormone (MCH) in the basolateral amygdala (BLA) and the resulting activation of orexin receptors or MCH receptors within the BLA produced deficits in sociability and mood-related behaviors. In the present study, we investigated the neural targets that were innervated by BLA neurons containing orexin receptors or MCH receptors. The viral vector system AAV2-CaMKII-ChR2-eYFP was injected into the BLA to trace the axonal tracts of BLA neurons. This axon labeling analysis led us to identify the prelimbic and infralimbic cortices, nucleus accumbens (NAc), dorsal striatum, paraventricular nucleus (PVN), interstitial nucleus of the posterior limb of the anterior commissure, habenula, CA3 pyramidal neurons, central amygdala, and ventral hippocampus as the neuroanatomical sites receiving synaptic inputs of BLA neurons. Focusing on these regions, we then carried out stimulus-dependent c-Fos induction analysis after activating orexin receptors or MCH receptors of BLA neurons. Stereotaxic injection of an orexin receptor agonist or an MCH receptor agonist in the BLA induced c-Fos expression in the NAc, PVN, central amygdala, ventral hippocampus, lateral habenula and lateral hypothalamus, which are all potentially important for depression-related behaviors. Among these neural correlates, the NAc, PVN and central amygdala were strongly activated by stimulation of orexin receptors or MCH receptors in the BLA, whereas other BLA targets were differentially and weakly activated. These results identify a functional connectivity of BLA neurons regulated by orexin and MCH receptor systems in sociability and mood-related behaviors.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors

Kim

Han

2016

Exp Neurobiol

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“…Regarding this, it will be interesting to test whether stress- and exercise-dependent behavioral changes are mediated at least in part by a G9a-dependent mechanism. Regarding that repeated stress markedly increased p-CaMKII and p-ERK levels in the BLA [3133], it will be interesting to examine whether MCH expression is affected by p-CaMKII and/or p-ERK pathways. Third, intraperitoneal injection of the MCH receptor antagonist, SNAP-94847, in mice subjected to repeated stress (2 h×14 d RST) ameliorated their anxiogenic social interactions and partially restored the reduced level of marble burying in the marbleburying test (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical analyses were carried out as previously described [3133]. Briefly, mice were anesthetized with a mixture (3.5:1) of ketamine hydrochloride (50 mg/ml) and xylazine hydrochloride (23.3 mg/ml) at a dose of 2.5 µl/g body weight.…”

Section: Methodsmentioning

confidence: 99%

Physical Exercise Counteracts Stress-induced Upregulation of Melanin-concentrating Hormone in the Brain and Stress-induced Persisting Anxiety-like Behaviors

Kim¹,

Han

2016

Exp Neurobiol

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Chronic stress induces anxiety disorders, whereas physical exercise is believed to help people with clinical anxiety. In the present study, we investigated the mechanisms underlying stress-induced anxiety and its counteraction by exercise using an established animal model of anxiety. Mice treated with restraint for 2 h daily for 14 days exhibited anxiety-like behaviors, including social and nonsocial behavioral symptoms, and these behavioral impairments lasted for more than 12 weeks after the stress treatment was removed. Despite these lasting behavioral changes, wheel-running exercise treatment for 1 h daily from post-stress days 1 - 21 counteracted anxiety-like behaviors, and these anxiolytic effects of exercise persisted for more than 2 months, suggesting that anxiolytic effects of exercise stably induced. Repeated restraint treatment up-regulated the expression of the neuropeptide, melanin-concentrating hormone (MCH), in the lateral hypothalamus, hippocampus, and basolateral amygdala, the brain regions important for emotional behaviors. In an in vitro study, treatment of HT22 hippocampal cells with glucocorticoid increased MCH expression, suggesting that MCH upregulation can be initially triggered by the stress hormone, corticosterone. In contrast, post-stress treatment with wheel-running exercise reduced the stress-induced increase in MCH expression to control levels in the lateral hypothalamus, hippocampus and basolateral amygdala. Administration of an MCH receptor antagonist (SNAP94847) to stress-treated mice was therapeutic against stress-induced anxiety-like behaviors. These results suggest that repeated stress produces long-lasting anxiety-like behaviors and upregulates MCH in the brain, while exercise counteracts stress-induced MCH expression and persisting anxiety-like behaviors.

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“…A decisive influence possibly lies in the spatial distribution of neuromodulators and the complex interaction of positive and negative feedback loops between the limbic system and hypothalamus (Figure 11). TRH expression is upregulated in the amygdala in response to stress (355) and amygdala kindling (356), but downregulated in hippocampus (357). Via two pathways, such as the stria terminalis and the ventral amygdalofugal pathway, the amygdala stimulates the PVN, the origin of hypophysiotropic TRH neurons, with cholinergic and glutamatergic terminals (358).…”

Section: Thyroid Allostasis In Various Physiological and Pathologicalmentioning

confidence: 99%

Thyroid Allostasis–Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming

Hoermann²,

et al. 2017

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The hypothalamus–pituitary–thyroid feedback control is a dynamic, adaptive system. In situations of illness and deprivation of energy representing type 1 allostasis, the stress response operates to alter both its set point and peripheral transfer parameters. In contrast, type 2 allostatic load, typically effective in psychosocial stress, pregnancy, metabolic syndrome, and adaptation to cold, produces a nearly opposite phenotype of predictive plasticity. The non-thyroidal illness syndrome (NTIS) or thyroid allostasis in critical illness, tumors, uremia, and starvation (TACITUS), commonly observed in hospitalized patients, displays a historically well-studied pattern of allostatic thyroid response. This is characterized by decreased total and free thyroid hormone concentrations and varying levels of thyroid-stimulating hormone (TSH) ranging from decreased (in severe cases) to normal or even elevated (mainly in the recovery phase) TSH concentrations. An acute versus chronic stage (wasting syndrome) of TACITUS can be discerned. The two types differ in molecular mechanisms and prognosis. The acute adaptation of thyroid hormone metabolism to critical illness may prove beneficial to the organism, whereas the far more complex molecular alterations associated with chronic illness frequently lead to allostatic overload. The latter is associated with poor outcome, independently of the underlying disease. Adaptive responses of thyroid homeostasis extend to alterations in thyroid hormone concentrations during fetal life, periods of weight gain or loss, thermoregulation, physical exercise, and psychiatric diseases. The various forms of thyroid allostasis pose serious problems in differential diagnosis of thyroid disease. This review article provides an overview of physiological mechanisms as well as major diagnostic and therapeutic implications of thyroid allostasis under a variety of developmental and straining conditions.

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TRH and TRH receptor system in the basolateral amygdala mediate stress-induced depression-like behaviors

Cited by 38 publications

References 66 publications

Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors

Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors

Physical Exercise Counteracts Stress-induced Upregulation of Melanin-concentrating Hormone in the Brain and Stress-induced Persisting Anxiety-like Behaviors

Thyroid Allostasis–Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming

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