Trends over three decades of the risk of second primary cancer among patients with head and neck cancer

Clinical features and prognostic factors in patients with head and neck cancer: Results from a multicentric study

“…In particular, a significant protective effect of two single nucleotide polymorphisms (SNPs) towards upper aero-digestive tract cancer (UADT) was reported for two alcohol dehydrogenase genes: ADH1B (rs1229984) and ADH7 (rs1573496) [20]. In Europe, the 5-year survival rate varies considerably according to anatomic site, 63.1% for cancer of the larynx, 48.5% for oral cavity, 39.8% for oropharynx and 25.5% for hypopharynx cancer [21]. About 40-60% of HNC patients develop recurrences, and around 20% of HNCs develop second primary cancer (SPC), both being associated with poorer survival [22].…”

Multiple Second Primary Oral Squamous Cell Carcinomas in a Nonsmoker and Nondrinker Woman: Case Report and Review of the Literature

“…14 Different factors other than smoking or drinking can be related with the development of the oral SCCs in our patient, such as RT utilized to treat breast cancer 4 years before the emerging of the first oral SCC and later for the SCC in the buccal mucosa, or perhaps viral infections as well as HPV infection. Jégu et al 15 reported that in a recent population-based estimated that 4.9% of SPC may be related to radiotherapy in head and neck cancer survivors in the USA. Rusthoven et al 16 explained that patients with primary oral cavity cancers treated with RT can be at an increased risk of second head and neck cancers compared with patients treated without RT, differently from cancers located in other areas of the head and neck as pharyngeal sites.…”

“…Lately, a rise in incidence of HPV-associated head and neck SCC has been recorded. 15 A recent study suggested that the infection of HPV in early-stage oral SCC enhances the susceptibility of developing secondary malignancy, especially HPV-18. 17 However, other authors reported a lower risk of SPT in HPV-positive oropharyngeal SCC, emphasizing that this fact may be a major contributor to the demonstrated superior survival outcomes among patients with HPV-positive disease.…”

Les organes artificiels

“…Les cancers des voies aéro-digestives supérieures sont placés au sixième rang des cancers dans le monde, le carcinome épidermoïde 5 étant le type histologique le plus fréquent [31]. Quand ce cancer est étendu à tout le larynx, une opération chirurgicale de type laryngectomie totale est nécessaire.…”