Trends of stage, grade, histology and tumour necrosis in renal cell carcinoma in a European centre surgical series from 1984 to 2010

Abstract

In contrast to data from Australia but similar to data from US cohorts, a statistically significant stage migration towards small RCCs was observed in this European cohort. Significant changes in tumour grade, histological subtype and TN were also observed.

Changing the Stage, Grade and Histological Subtypes of Renal Cell Carcinomas during 10 Years Period

“…The male/female ratio may be different in the studies. While this ratio was 1.9 in a study from China (Chen et al, 2009), was 1.39 in a study from Austria (Pichler et al, 2012). We found the male/female ratio was 2.13 in the patients with RCCs.…”

“…The proportion of grade II tumours was between 43 and 61.5%. There is an increasing representation of grade III and IV tumours over time, from 12.7 to 20.3% and decreasing the proportion of grade I tumours from 32 to 14.8% in an analysis of 2,739 patients (Pichler et al, 2012). Additionally, the authors reported that there was a significant increase of grade III tumours over time, from 17.6 to 30.8% and decreasing proportion of grade I tumours from 16.2 to 7.1% (Doeuk et al, 2010).…”

“…The patients with organ confined tumours (pT1 and pT2) have decreased from 83.6 to 72.5%, in the contrary, pT1b tumours were increased from 24.4 to 29.7% in our study. The authors reported that the incidence of organ confined tumour was increased from 36.9 to 73.2% during the 27 years (Pichler et al, 2012); the other study demonstrated that the percentage of organ confined tumours was 66.7, 56.2 and 65.6% in the three study group respectively (Nason et al, 2014). The patients with local advanced tumours (pT3 and pT4) have increased during the study period (from 16.2 to 27.3%).…”

“…Although, the etiology of RCC is unclear, smoking, obesity, antihypertensive therapy, coffee, tea, Western diet (high in fat and protein, low vegetables and fruits) are risk factors (Chen et al, 2009). In a study from Austria, the authors found that, the median age of the patients were between 61 and 65 over the 27 years (Pichler et al, 2012). We found the mean age of the patients was 61.46 and 58.5 in the first and second 5 years.…”

“…Higher grade is associated with the biological aggressiveness and increased metastatic potential of the tumour. Most of the RCCs are classified as grade II in the studies (Pichler et al, 2012;Ozbek et al, 2013). The proportion of grade II tumours was between 43 and 61.5%.…”