Trends of skin diseases in organ-transplant recipients transplanted between 1966 and 2006: a cohort study with follow-up between 1994 and 2006

Wisgerhof, Hermina C.; Edelbroek, Jeroen R. J.; Fijter, Johan W. de; Feltkamp, Mariet C.W.; Willemze, Rein; Bavinck, Jan Nico Bouwes

doi:10.1111/j.1365-2133.2009.09529.x

Cited by 31 publications

(31 citation statements)

References 28 publications

(56 reference statements)

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“…Numerous studies have pointed out that skin infections and Non Melanoma Skin Cancers (NMSCs) are commonly occurring complications for transplant recipients [6,8,11,12,13,14] due to the long-term immunosuppression used to prevent transplant rejection. Conversely, scant clinical data are available regarding the incidence of inflammatory skin diseases in patients with solid organ transplantation (Table 4).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Cutaneous Diseases in Renal Transplant Recipients

Savoia

Cavaliere

Zavattaro

et al. 2016

IJMS

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Kidney transplant recipients frequently suffer from skin infections and malignancies, possibly due to the effects of long-term immunosuppressive therapy. While the relationships between immunosuppression and these pathological conditions have been widely investigated, little is known about the relative incidence and characteristics of inflammatory skin diseases in this type of patient. In this study, we analyze the incidence of a number of inflammatory cutaneous diseases in a cohort of patients who underwent kidney transplantation. Although our study shows a relatively low incidence of these pathologies in transplanted patients—in agreement with the general action of immunosuppressant therapies in reducing inflammation—we scored a different efficacy of the various immunosuppressive regimens on inflammatory and autoimmune skin diseases. This information can be key for designing immunosuppressive regimens and devising accurate follow-up protocols.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Cutaneous Diseases in Renal Transplant Recipients

Savoia

Cavaliere

Zavattaro

et al. 2016

IJMS

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“…Folgende spezielle Aspekte können für organtransplantierte Patienten mit Hautinfektionen herausgestellt werden: F Im Vordergrund stehen bakterielle, mykotische und virale Hautinfektionen, die den ersten Hinweis für eine systemische Manifestation geben können [4,6,7,12,13]. F Die Häufigkeit dieser Infektionen ist sehr hoch, wobei 55-97% organtransplantierter Patienten betroffen sind [13].…”

Section: Hautinfektionen Nach Transplantationunclassified

“…F Die Häufigkeit dieser Infektionen ist sehr hoch, wobei 55-97% organtransplantierter Patienten betroffen sind [13]. F Von besonderer Bedeutung ist, dass kutane Infektionen nach Organtransplantationen nicht selten schwere Verlaufsformen und ungewöhnliche ("atypische") klinische Bilder aufweisen können.…”

Section: Hautinfektionen Nach Transplantationunclassified

Hautinfektionen nach Transplantation

Wolf

2010

Hautarzt

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Skin infections after transplantation are frequent and of special importance because they may be quite severe. The spectrum of dermatologic infections in transplant recipients includes bacterial, mycotic and viral diseases. Pyoderma, herpes virus 6/7, herpes simplex virus, varicella-zoster virus, cytomegalovirus and candida infections predominate. Rare pathogens must be also considered. Cutaneous infections can be divided into three phases following transplantation. Diagnosis and adequate early therapy together with specific prophylaxis and follow-up of transplant patients should be strived for to avoid life-threatening complications.

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“…S olid organ transplant recipients (SOTRs) maintained on immunosuppressive therapy have a high risk of developing malignancies, especially nonmelanoma skin cancer (NMSC). [1][2][3][4][5] Cutaneous squamous cell carcinoma (SCC) is the most common, with a 50 to 250 times higher incidence in SOTRs than in the general population. 3 SCCs in SOTRs are also more aggressive, with higher rates of metastatic disease and local invasion.…”

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confidence: 99%