Trends of microneedle technology in the scientific literature, patents, clinical trials and internet activity

Ingrole, Rohan S.J.; Azizoğlu, Erkan; Dul, Maria; Birchall, James Caradoc; Gill, Harvinder Singh; Prausnitz, Mark R.

doi:10.1016/j.biomaterials.2020.120491

Cited by 94 publications

(59 citation statements)

References 40 publications

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“…Science in this area is potentially advancing to safer supplies of transdermal drugs using the polymeric MNs method [405,406]. There has been noteworthy progress in the fields of transdermal medication using polymer MN [297]. With new polymeric substrates and manufacturing techniques [138,407,408], polymeric MNs can not only be administered upon request but can Despite major developments in the development, detection, and control of MNs for the delivery of transdermal drugs, biomedical applications are still early in existence and have not advanced toward large-scale manufacturing and practicality [355].…”

Section: Discussionmentioning

confidence: 99%

“…Science in this area is potentially advancing to safer supplies of transdermal drugs using the polymeric MNs method [ 405 , 406 ]. There has been noteworthy progress in the fields of transdermal medication using polymer MN [ 297 ]. With new polymeric substrates and manufacturing techniques [ 138 , 407 , 408 ], polymeric MNs can not only be administered upon request but can be individually customized to improve the quality of life of patients and achieve better therapeutic effects [ 107 , 161 , 399 ].…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, many preclinical and clinical trials have been conducted that involve polymeric MN devices. In the fabrication of an MN master template, it is required to have thousands of USD and the access and arrangement of facilities such as a clean room and photo-etching equipment for the implementation of techniques such as deep-reactive ion-etching, laser-etching, and anisotropic wet etching [ 296 , 297 ]. Hurdles are encountered along the way of clinical translation of this device [ 298 ].…”

Section: Polymeric Mn Based Devices and Preclinical And Clinical Trialsmentioning

confidence: 99%

“…Hurdles are encountered along the way of clinical translation of this device [ 298 ]. The current production methods are often limiting as these methods employ batch production processes [ 297 , 299 ]. The biggest obstacle is in developing processes that allow for robust, efficient, and high throughput production in an industrial setting [ 31 ].…”

Section: Polymeric Mn Based Devices and Preclinical And Clinical Trialsmentioning

confidence: 99%

“…Several MN-based drugs are currently being produced by various firms, including Zosano Pharma (USA), 3M (USA), Sanofi Pasteur MSD (USA), Becton-Dickinson (BD) Technologies (USA), Valeritas (USA), Nano pass Technologies (Israel), MN Therapy System (USA), and Rodan+ Fields (USA). Remarkably, no drug delivery product based on the MN array is yet commercialized [ 297 ]. Micro-injection systems are also a type of MN-based device being developed.…”

Section: Polymeric Mn Based Devices and Preclinical And Clinical Trialsmentioning

confidence: 99%

See 4 more Smart Citations

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical practice. The review reveals that polymers are most appropriately used for dissolvable and swellable MNs due to their wide range of tunable properties and that natural polymers are an ideal material choice as they structurally mimic native cellular environments. It has also been concluded that natural and synthetic polymer combinations are useful as polymers usually lack mechanical strength, stability, or other desired properties for the fabrication and insertion of MNs. This review evaluates fabrication methods and materials choice, disease and health conditions, clinical challenges, and the future of MNs in public healthcare services, focusing on literature from the last decade.

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Section: Discussionmentioning

confidence: 99%

“…Science in this area is potentially advancing to safer supplies of transdermal drugs using the polymeric MNs method [ 405 , 406 ]. There has been noteworthy progress in the fields of transdermal medication using polymer MN [ 297 ]. With new polymeric substrates and manufacturing techniques [ 138 , 407 , 408 ], polymeric MNs can not only be administered upon request but can be individually customized to improve the quality of life of patients and achieve better therapeutic effects [ 107 , 161 , 399 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Polymeric Mn Based Devices and Preclinical And Clinical Trialsmentioning

confidence: 99%

Section: Polymeric Mn Based Devices and Preclinical And Clinical Trialsmentioning

confidence: 99%

Section: Polymeric Mn Based Devices and Preclinical And Clinical Trialsmentioning

confidence: 99%

See 3 more Smart Citations

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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show abstract

Concept Design of Transdermal Microneedles for Diagnosis and Drug Delivery: A Review

2021

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Microneedles (MNs) are one of intriguing approach for efficient transdermal drug delivery that penetrates the protective skin barrier in a painless and less invasive way. In recent years, multidisciplinary studies have been conducted to improve their properties to meet stringent requirements and obtain market release approval. This review aims to summarize the latest concept design with unique properties in the advancement of transdermal MNs for diagnosis and therapeutic application. Numerous significant innovation strategies in improving MNs in aspects of adhesion ability, dosing capacity, drug‐controlled release, diffusion control ability, site‐targeted and on‐demand drug delivery, and biomarker or drug release monitoring are presented. Given that the majority of technologies used in such design are exclusively laboratory‐based, striving toward commercialization is a critical aspect of the revolution. Key challenges and future perspectives in industrial and economic aspects are identified with the intention of translating the reviewed technologies into marketable products.

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Efficient Drug Delivery into Skin Using a Biphasic Dissolvable Microneedle Patch with Water‐Insoluble Backing

Xia

Prausnitz

2021

Adv Funct Materials

Self Cite

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Dissolvable microneedle patches (MNPs) enable simplified delivery of therapeutics via the skin. However, most dissolvable MNPs do not deliver their full drug loading to the skin because only some of the drug is localized in the microneedles (MNs), and the rest remains adhered to the patch backing after removal from the skin. In this work, biphasic dissolvable MNPs are developed by mounting water-soluble MNs on a water-insoluble backing layer. These MNPs enable the drug to be contained in the MNs without migrating into the patch backing due to the inability of the drugs to partition into the hydrophobic backing materials during MNP fabrication. In addition, the insoluble backing is poorly wetted upon MN dissolution in the skin, which significantly reduces drug residue on the MNP backing surface after application. These effects enable a drug delivery efficiency of >90% from the MNPs into the skin 5 min after application. This study shows that the biphasic dissolvable MNPs can facilitate efficient drug delivery to the skin, which can improve the accuracy of drug dosing and reduce drug wastage.

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Trends of microneedle technology in the scientific literature, patents, clinical trials and internet activity

Cited by 94 publications

References 40 publications

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Concept Design of Transdermal Microneedles for Diagnosis and Drug Delivery: A Review

Efficient Drug Delivery into Skin Using a Biphasic Dissolvable Microneedle Patch with Water‐Insoluble Backing

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