Trends of kidney transplantation in Japan in 2018: data from the kidney transplant registry

Yamada, Takashi; Mieno, Makiko; Ichimaru, Naotsugu; Morita, Ken; Nakamura, Michio; Hotta, Kiyohiko; Kenmochi, Takashi; Yuzawa, Kenji

doi:10.1186/s41100-019-0199-6

Cited by 46 publications

(50 citation statements)

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“…However, it is not clear from the text how the authors ensured that the granules they saw were in fact lipofuscin. In addition, this cohort included living donor KT recipients in Japan that has a high rate of performing ABO incompatible transplants [29]. The implications of previous rejection episodes, desensitization protocols and heme deposits were not accounted for.…”

Section: Discussionmentioning

confidence: 99%

“…PF: Involved with the conception and the design, and the analysis and interpretation of data; substantively revised the manuscript; approved the submitted version; agree both to be personally accountable for their contributions and to ensure that questions related to the accuracy or integrity of any part of the work. SS: Involved with the conception and the design, and the analysis and interpretation of data; drafted the manuscript; approved the submitted version; agree both to be personally accountable for their contributions and to ensure that questions related to the accuracy or integrity of any part of the work [29].…”

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confidence: 99%

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A case report on lipofuscin deposition in a graft biopsy two years after kidney transplantation: an insignificant bystander or a pathogenic benefactor?

et al. 2019

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Background Lipofuscin deposition is a characteristic manifestation of aging. There is very limited literature in humans and in animals describing these deposits in native kidneys. Overall, it is thought to be non-pathogenic and successful transplants from a donor with lipofuscin deposits have been reported. We present the case of a patient who underwent a kidney transplant and a for-cause biopsy post-transplantation incidentally revealed lipofuscin deposition. Case presentation A 48-year old gentleman with a past medical history of diabetes, hypertension, coronary artery disease, and ischemic and then hemorrhagic cardiovascular accident underwent a successful kidney transplant. His donor was an expanded criteria donor with no major past medical history. Post-transplant course was complicated by delayed graft function requiring one dialysis treatment for hyperkalemia. After that he had an uneventful course and achieved a baseline creatinine of 1.2 mg/dL, with no proteinuria. On a routine 19-month follow-up he was noted to have proteinuria and an antibody against the major-histocompatibility-complex class I-related chain A. A graft biopsy revealed acute antibody-mediated rejection and impressive lipofuscin deposition. He was subsequently treated with an antibody-mediated rejection protocol that included high dose steroids, Rituximab, plasmapheresis, and intravenous immunoglobulin, but responded poorly to this regimen. A 6-month follow up biopsy continued to show lipofuscin deposition, with similar microvascular injury scores and 12-months later his creatinine remained stable but his proteinuria worsened. Patient was struggling with recurrent infectious episodes requiring hospitalizations and thus no further diagnostic or therapeutic treatments were pursued. Conclusions Lipofuscin deposition has been reported in solid organ transplants but the significance and cause are not well understood. Several physiologic and some pathologic causes to these deposits have been reported including age, diabetes, medications and a genetic syndrome. We propose that immunologic causes such as rejection in the presence of other risk factors could potentiate the oxidative stress leading to excessive lipofuscin deposition in kidney transplants. In the case of our patient, we conclude that these deposits were likely recipient-derived, and postulate that the cumulative burden of inflammation from rejection, and underlying medical conditions led to increased lipofuscin deposition. We speculate them to be an innocent bystander.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

A case report on lipofuscin deposition in a graft biopsy two years after kidney transplantation: an insignificant bystander or a pathogenic benefactor?

et al. 2019

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“…Thus, it is mandatory for Japanese society to find a solution to these issues for sustainability. The increase in the number of peritoneal dialysis procedures 1 and kidney transplants (still fewer than 2000 per year and nearly 90% from living donors) 11…”

Section: Future Perspectivesmentioning

confidence: 99%

Global Dialysis Perspective: Japan

Hanafusa

Fukagawa

2020

Kidney360

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“…In Japan and many others Asian countries such as India and Philippines, live donor source accounts for over 80% of all kidney transplants. This compared to less than 50% in United Kingdom, United States, and Australia [1,2]. Consequently, marginal live kidney donors are being considered for transplantation but there are growing concerns that such practices may inadvertently expose these live donors to unacceptable risks of adverse outcomes postdonation compared to the average live donor.…”

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confidence: 99%