Trends of Gold Nanoparticle-based Drug Delivery System in Cancer Therapy

Ajnai, Giimel; Chiu, Alan; Kan, Tzu-Chun; Cheng, Chun; Tsai, Teh Hua; Chang, Jungshan

doi:10.1016/j.jecm.2014.10.015

Cited by 164 publications

(98 citation statements)

References 78 publications

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“…Synthesis of gold nanoparticles using HAuCl 4 precursor, Imperata cylindrica L leaf extract, methanol, n-hexane, ethyl acetate pro analysis and aquadest. The sample using Imperata cylindrica L (ICL) were taken from Universitas Indonesia area.…”

Section: Experimental Methods Materialsmentioning

confidence: 99%

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Effect of Concentration of Imperata Cylindrica L Leaf Extract on Synthesis Process of Gold Nanoparticles

Saputra¹,

Yulizar

Sudirman

2018

JUSAMI

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EFFECT OF CONCENTRATION OF IMPERATA CYLINDRICA L LEAF EXTRACT ON SYNTHESIS PROCESS OF GOLD NANOPARTICLES.Gold Nanoparticles (GoldNPs) successful was performed using HAuCl 4 precursor as Au 3+ ion source with 7x10 -4 M concentration. The research aims to knows effect of concentration variation of Imperata cylindrica L leaf extract on synthesis process of gold nanoparticles. The research used of green synthesis method. Colloid of nanoparticles which is formed in analyzed using UV-Vis Spectrophotometer, FT-IR Spectroscopy, PSA, PZC, XRD and TEM. The results of synthesis showed the best concentration of Imperata cilyndrica L leaf extract at 3,46%, happen a shift of wavelength at UV-Vis from 216 nm to 530 nm with 1.779 absorbance value. The PSA analysis showed a particle size of 51.87 nm and a PZC value of -19.2 mV. The result of FT-IR indicated a shift of wavenumber in the hidroxyl group from 3354 cm -1 to 3390 cm -1 and showed a interaction of hydroxyl group at imperata cylindrica L leaf extract with Au 3+ ion. TEM analysis shows the morphology of GoldNPs that spherical shape with a particle size of 20 nm. XRD calculation results show crystallite size of gold nanoparticles is 15.47 nm.Keywords: Imperata cylindrica L, Gold Nanoparticles (GoldNPs), Green Synthesis ABSTRAK PENGARUH KONSENTRASI EKSTRAK DAUN ILALANG (IMPERATA CYLINDRICA L) DALAM PROSES SINTESIS NANOPARTIKEL EMAS. Nanopartikel Emas (GoldNPs) berhasil dilakukan menggunakan prekursor HAuCl 4 sebagai sumber ion Au3+ dengan konsentrasi 7x10 -4 M. Tujuan penelitian ini yaitu ingin mengetahui pengaruh variasi konsentrasi ekstrak daun ilalang dalam proses pembentukan nanopartikel emas. Metode yang digunakan pada penelitian ini yaitu metode green synthesis. Koloid nanopartikel yang terbentuk di karakterisasi menggunakan Spektrofotometer UV-Vis, Spektroskopi FT-IR, PSA, PZC, XRD dan TEM. Hasil penelitian menunjukkan konsentrasi ekstrak daun ilalang yang terbaik yaitu 3,46% terlihat adanya pergeseran panjang gelombang pada UV-Vis dari 216 nm menjadi 530 nm dengan nilai absorbansi tertinggi yaitu 1,779. Analisis PSA menunjukkan ukuran rata-rata nanopartikel emas sebesar 51,87 nm dan nilai PZC sebesar -19,2 mV. Hasil FT-IR menunjukkan adanya interaksi pada gugus hidroksil pada ekstrak daun ilalang dengan ion Au 3+ , terlihat adanya pergeseran bilangan gelombang dari 3354 cm -1 menjadi 3390 cm -1 . Berdasarkan analisis TEM menunjukkan morfologi nanopartikel emas berbentuk sphere dengan ukuran partikel rata-rata 20 nm. Hasil perhitungan XRD menunjukkan ukuran kristalit nanopartikel emas sebesar 15,47 nm.

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Section: Experimental Methods Materialsmentioning

confidence: 99%

“…Au nanoparticles have several advantages in such fields as catalysts [1], antibacterial [2], sensors [3] and drug delivery [4]. In addition to having superior properties, AuNPs also has a good particle size stability.…”

Section: Introductionmentioning

confidence: 99%

Effect of Concentration of Imperata Cylindrica L Leaf Extract on Synthesis Process of Gold Nanoparticles

Saputra¹,

Yulizar

Sudirman

2018

JUSAMI

View full text Add to dashboard Cite

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“…No harmful chemicals are used in AuNPs so long-term damage is not an issue. This form of energy also does not emit any sort of radiation toxic to the human body making it safer and healthier for patients than other sorts of targeted radiation techniques (30).…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Update on Nanotechnology-based Drug Delivery Systems in Cancer Treatment

Pfeffer

Singh

2017

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Abstract. The Cancer is the second leading cause of death, following heart diseases (1), killing approximately eight million people (600,000 per year) and affecting nearly fourteen million (2).The rate at which cancer is emerging is only increasing as time goes on due to such factors as increased pollution, radiation, lack of exercise and a balanced diet, among other variables such as genetics (3). Anyone of these factors can lead to a mutation in the DNA of our cells like oncogenes and develop into cancer. The immortalization and sustainability of individual cells capable of reproducing at astonishing rates, overtake all the healthy functional cells, and eventually lead to death.The most common types of treatment against cancer include chemotherapy, surgery, radiation, and a combination of any of these treatments. However, there are challenges associated with the traditional treatments -non-specificity, toxicity, etc. The challenge of current drug therapy is the optimization of the pharmacological action of the drug, and the minimization of its toxic side effect. Local concentration of the drug at the cancer sites needs to be high, while at other tissues low to prevent any negative reactions. Application of nanotechnology in cancer treatment has the potential to solve these limitations. Designing nanoparticles loaded with multifunctional drugs, and functionalizing their surfaces with recognition proteins can target specific cancer cells (4, 5). The advantages of such targeting include the drug amount needed to achieve a therapeutic effect may be significantly reduced as well as the drug concentration on the cancer site can be increased without any bad effects on healthy cells (6).Several nanoparticle based drug delivery systemsnanodisks, HDL nanostructures, gold nanoparticles, and viral nanoparticles -have shown encouraging results in cancer therapy. Progress has been made in studying the biological features of cancer to enhance the use of nanoparticlesovercoming biological barriers, and recognizing cancerous tissue vs. healthy tissue. Looking forward, nanodrugs have great potential in cancer therapy due to their unique properties -minimizing toxicity to healthy cells, overcoming multidrug resistance (MDR), and overcoming poor solubility of anti-cancer drugs. 5975

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“…This review investigates other nanosystems such as metallic nanoparticles like gold (Au) [112][113][114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130] and silver (Ag) , bimetallic nanoparticles like iron cobalt (Fe-Co) [78][79][80][92][93][94][95][96][97]108,109] and iron platinum (Fe-Pt) [155][156][157][158][159][160][161][162][163][164][165][166][167][168][169][170][171][172] and metal oxides including titanium dioxide (TiO 2 ) [1...…”

Section: Introductionmentioning

confidence: 99%