Trends of Diabetes and Prediabetes Prevalence among Korean Adolescents From 2007 to 2018

Kim, Ji Hyun; Lim, Jung Sub

doi:10.3346/jkms.2021.36.e112

Cited by 20 publications

(17 citation statements)

References 34 publications

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“…YOD shares common risk factors for late-onset T2DM. In this respect, it is evident that the increasing prevalence of YOD is associated with an increase in people who are overweight or obese worldwide [ 11 , 12 ]. According to the KNHANES study of 2005 to 2014, obese individuals aged 10 to 29 years showed a seven-fold higher prevalence of diabetes than non-obese individuals at the same age [ 7 ].…”

Section: Risk Factors and Clinical Characteristicsmentioning

confidence: 99%

“…According to the KNHANES study of 2005 to 2014, obese individuals aged 10 to 29 years showed a seven-fold higher prevalence of diabetes than non-obese individuals at the same age [ 7 ]. The prevalence of diabetes was 0.19%, 0.34%, and 1.06% among normal-weight, overweight, and obese South Korean adolescents aged 10 to 18 years, respectively [ 12 ].…”

Section: Risk Factors and Clinical Characteristicsmentioning

confidence: 99%

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Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need

Yang

Han

Sohn

et al. 2021

Korean J Intern Med

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The prevalence of young-onset (diagnosis at age < 40 years) type 2 diabetes mellitus (T2DM) is increasing globally. Young-onset T2DM has a common pathophysiology of glucose dysregulation as in late-onset T2DM. However, it presents a greater association with obesity and a more rapid decline in β-cell function than late-onset T2DM. Accumulating evidence indicates that disease progression in young-onset T2DM is rapid, resulting in early and frequent development of microvascular and macrovascular complications, as well as premature death. Improper management and low adherence to medical therapy are important issues in young-onset T2DM. This review discusses the epidemiology, disease entity, and clinical issues associated with young-onset T2DM. We also present the prevalence and clinical characteristics of patients with young-onset T2DM in South Korea.

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Section: Risk Factors and Clinical Characteristicsmentioning

confidence: 99%

Section: Risk Factors and Clinical Characteristicsmentioning

confidence: 99%

Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need

Yang

Han

Sohn

et al. 2021

Korean J Intern Med

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“…From 2016 to 2018, in South Koreans aged 10 to 18 years, the prevalence of diabetes was 0.43% [ 48 ], and ours is one of the countries with the lowest incidence of diabetes. However, the prevalence of diabetes in our study population is high, and similar finding has already been reported by other authors.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Serum Total Insulin-Like Growth Factor Binding Protein-3 with Insulin-Like Growth Factor-I and Glucose Tolerance in Korean Children and Adolescents

Kim

et al. 2021

International Journal of Endocrinology

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Insulin is important in glucose metabolism. However, insulin-like growth factor binding protein (IGFBP) also plays an important role in glucose homeostasis, although the IGF-independent role of IGFBP-3 in the glucose intolerance state is poorly understood. We investigated the relationship of serum IGF-I with total IGFBP-3 levels and glucose tolerance in Korean children and adolescents who underwent the oral glucose tolerance test (OGTT). A total of 187 children without known diabetes underwent OGTT, and data related to their clinical and laboratory parameters were collected. Serum IGF-I and total IGFBP-3 levels, fasting plasma glucose levels, lipid profiles, insulin levels, C-peptide levels, homeostasis model assessment of insulin resistance (HOMA-IR) index, and glycated hemoglobin (HbA1c) levels were measured. Serum IGF-I and total IGFBP-3 levels were significantly higher in individuals with impaired glucose tolerance and type 2 diabetes (DM) than in those with normal glucose tolerance (NGT) ( P < 0.05 ). Serum IGF-I and IGFBP-3 levels were correlated with age, HbA1c, C-peptide, insulin, and HOMA-IR in the NGT group. However, these relationships were altered in patients with glucose intolerance, especially in those with DM. In the DM group, serum IGF-I and total IGFBP-3 levels were positively correlated with fasting plasma glucose and HbA1c levels. In addition, total IGFBP-3 levels were positively correlated with total cholesterol and low-density lipoprotein cholesterol and IGF-I levels but not with age or body mass index. The IGF-I-IGFBP-3 axis, especially IGFBP-3, may be involved in the pathogenesis and metabolic control of glucose intolerance, specifically in diabetes patients. Moreover, IGFBP-3 might be a therapeutic marker.

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“…Hyperglycemia and insulin deficiency can affect bone cell functions, as well as the bone marrow fat, thus impairing the bone strength, geometry, and microarchitecture (9). With the epidemic of childhood obesity, the prevalence of prediabetes among children and adolescents has increased over the past decade (10). Unlike adults, Pollock et al found that total body bone mineral content (BMC) was 4% lower in overweight children with prediabetes than in those without prediabetes (11).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Prediabetes and Bone Mass in Adolescents: Analysis of the National Health and Nutrition Examination Survey From 2005 to 2010

Yin

2021

Front. Endocrinol.

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ObjectiveThe purpose of this study was to observe the relationship between impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and bone mineral density (BMD) in different sites in adolescents.MethodsA retrospective study was conducted on adolescents age 12–19 years of the United States. Data were extracted from the National Health and Nutrition Examination Survey (NHANES) 2005–2006, 2007–2008, and 2009–2010 cycles. IFG was defined as fasting plasma glucose (FPG) levels that were ≥5.6 and <7.0 mmol/L. IGT was defined as 2-h plasma glucose levels that were ≥7.8 and <11.1 mmol/L after the oral glucose tolerance test (OGTT).ResultsAfter controlling for age, gender, race, and body mass index (BMI) Z-score, adolescents in different categories of IGT had significantly different levels of areal BMD (aBMD) and bone mineral apparent density (BMAD) (IGT main effect: P < 0.05 for all, two-way ANOVA). There was no main effect between different categories of IFG with regard to aBMD and BMAD (P > 0.05). There was no interaction between IFG and IGT with regard to aBMD and BMAD (P > 0.05). In multiple regression analysis, the 2-h plasma glucose maintained an independent association with femoral neck aBMD (β = −0.011, 95% CI: −0.017~−0.006, P < 0.001, R2 = 0.012), total femur aBMD (β = −0.015, 95% CI: −0.021~−0.009, P < 0.001, R2 = 0.018), total spine aBMD (β = −0.015, 95% CI: −0.020~−0.010, P < 0.001, R2 = 0.018), and total spine BMAD (β = −0.002, 95% CI: −0.003~0.000, P = 0.006, R2 = 0.003).ConclusionThe present study demonstrates that BMD was decreased in adolescents with IGT. Two-hour plasma glucose, not FPG, negatively correlated with BMD. The effect of 2-h plasma glucose was consistent across the sites of bone.

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Trends of Diabetes and Prediabetes Prevalence among Korean Adolescents From 2007 to 2018

Cited by 20 publications

References 34 publications

Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need

Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need

Relationship of Serum Total Insulin-Like Growth Factor Binding Protein-3 with Insulin-Like Growth Factor-I and Glucose Tolerance in Korean Children and Adolescents

The Relationship Between Prediabetes and Bone Mass in Adolescents: Analysis of the National Health and Nutrition Examination Survey From 2005 to 2010

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