Trends in tuberculosis notification and mortality and factors associated with treatment outcomes in Serbia, 2005 to 2015

Stošić, Maja; Grujičić, Sandra Šipetić; Grgurević, Anita; Kuruc, Vesna; Ristic, Lidija; Antonijevic, Gordana; Jevtic, Miroslav; Plavša, Dragana; Vukicevic, Tatjana Adzić

doi:10.2807/1560-7917.es.2020.25.1.1900322

Cited by 6 publications

(6 citation statements)

References 17 publications

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“…Notably, our study highlights a lower rate of successful treatment among students compared to farmers. This observation aligns with the younger age demographic of students, coinciding with a higher successful treatment rate in younger age groups [34,35,37]. Studies underscore the elevated likelihood of etiologically positive PTB among farmers in China [41].…”

Section: Discussionsupporting

confidence: 70%

Multivariate regression analysis affecting successful treatment of pulmonary tuberculosis patients in western China: a retrospective study in a high-incidence area

Zhou,

Li,

et al. 2024

Preprint

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Background Guizhou, situated in western China, exhibits a high incidence of pulmonary tuberculosis (PTB) alongside comparatively challenging medical and economic conditions. Our objective was to investigate the determinants influencing successful PTB treatment and their scope, aiming to provide a scientific foundation for targeted interventions and enhancing treatment efficacy. Methods Data encompassing all PTB cases registered in Guizhou's China Disease Prevention and Control Information System from 2017 to 2022 were analyzed. Using the successful treatment rate as the dependent variable, initial univariate analysis of independent variables was conducted, followed by multilevel binary logistic regression analysis to assess variables demonstrating statistically significant disparities. Results A total of 139,414 patients, with an average age of 44 years, were included in the study, comprising 89,802 males (64.41%) and 49,612 females (35.59%). Among them, 66,316 (47.57%) were etiologically positive, and 22,795 (16.35%) had comorbidities. The successful treatment rate stood at 95.77%, with a cure rate of 42.54%. 9 factors were identified to influence the successful treatment rate. These included a higher proportion of females compared to males (OR = 1.178, 95%CI = 1.111–1.249), a higher ratio of students versus farmers (OR = 1.960, 95%CI = 1.649–2.330), and a greater proportion of etiologically negative cases compared to etiologically positive (OR = 1.831, 95%CI = 1.725–1.942). Additionally, initial treatment showed higher success rates than retreatment (OR = 3.046, 95%CI = 2.836–3.272), and PTB patients without comorbidities fared better than those with comorbidities (OR = 1.303, 95% CI = 1.217–1.394). The use of fixed-dose combination (FDC) therapy yielded higher success rates than non-FDC treatment (OR = 1.296, 95%CI = 1.206–1.393). Furthermore, successful treatment rates were lower among the Miao ethnic group (OR = 0.874, 95%CI = 0.809–0.945) and higher among the Buyi (OR = 1.270, 95%CI = 1.137–1.419) compared to the Han. Age also played a significant role, with lower success rates observed in the 41–60 age group (OR = 0.731, 95%CI = 0.638–0.838) and the lowest rates among those aged 61 years and older (OR = 0.604, 95%CI = 0.527–0.693). Conclusions Western China faces ongoing challenges in enhancing its PTB treatment capacity and should prioritize the promotion of FDC therapy. Risk factors that influence treatment outcomes for PTB include male gender, advanced age, belonging to the Miao ethnic group, occupation as a farmer, etiological positivity, retreatment status, and comorbidities such as diabetes and HIV/AIDS. Further investigation is warranted to explore the disparities in successful treatment rates among different ethnicities.

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Section: Discussionsupporting

confidence: 70%

Multivariate regression analysis affecting successful treatment of pulmonary tuberculosis patients in western China: a retrospective study in a high-incidence area

Zhou,

Li,

et al. 2024

Preprint

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“…However, the observed lack of information about the current TB incidence in Serbia was quite surprising. Every other respondent answered that the incidence is increasing, despite the fact that it has been steadily declining for the last 15 years [24]. One of the possible explanations is that people still believe TB is a massive, unsolvable problem that has been going on for decades.…”

Section: Discussionmentioning

confidence: 99%

Knowledge is the most powerful tool in the fight against tuberculosis

Ilic,

Bjelic,

Javorac

et al. 2023

J Infect Dev Ctries

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Introduction: In October 2022, after almost two years, tuberculosis reclaimed its first place as the world's deadliest infectious disease, replacing COVID-19. Since knowledge is the most powerful tool to combat any disease, the primary goal of our study was to assess patients' knowledge of tuberculosis and its relationship to their socio-demographic status. Methodology: This cross-sectional study included 1,067 respiratory patients who were surveyed between November 2021 and June 2022 at the Institute for Pulmonary Diseases of Vojvodina (Serbia). They completed a questionnaire designed for this study. Results: The majority of patients (53.7%) were female; over two-thirds (70.8%) were ≥ 60 years; every fifth (23.2%) was either with or without primary school; every third (33.3%) was financially poor. Although the majority of patients (97.8%) were aware that tuberculosis is an infectious disease, only 44.2% knew the etiology. Around 3/4 (72.6%) were aware of a tuberculosis vaccine. Hospitalized patients had better knowledge that the vaccine helps prevent tuberculosis than ambulatory patients (p = 0.047). Only 16% of patients in both groups knew that tuberculosis incidence is decreasing in Serbia (p = 0.074). Good knowledge about tuberculosis was reported by 71.5%. Hospitalized patients showed better knowledge than ambulatory patients (p = 0.032). Patients with a higher level of education and higher monthly income were independent predictors of better knowledge of tuberculosis. Conclusions: The study underlines the need to promote knowledge about tuberculosis, particularly among chronic patients, socially vulnerable and refugees, especially in light of the pandemic and emerging economic problems in the region.

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“…Discorre-se que para prevenir a perda de seguimento e mortalidade e para alcançar uma melhor adesão ao tratamento, o gerenciamento de casos deve ser melhorado no sentido de fornecer intervenções intersetoriais holísticas centradas no paciente e apoio durante o tratamento. Dessa forma, os trabalhadores expostos a todas essas medidas, precisam ter acesso a estratégias que promovam seu cuidado e permitam a continuidade do trabalho exercido 11 .…”

Section: Discussionunclassified

Repercussões da pandemia de COVID-19 na vigilância em saúde do trabalhador em unidades básicas de saúde

Venancio

Faria

Koopmans

2022

GANJ

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Trends in tuberculosis notification and mortality and factors associated with treatment outcomes in Serbia, 2005 to 2015

Cited by 6 publications

References 17 publications

Multivariate regression analysis affecting successful treatment of pulmonary tuberculosis patients in western China: a retrospective study in a high-incidence area

Multivariate regression analysis affecting successful treatment of pulmonary tuberculosis patients in western China: a retrospective study in a high-incidence area

Knowledge is the most powerful tool in the fight against tuberculosis

Repercussões da pandemia de COVID-19 na vigilância em saúde do trabalhador em unidades básicas de saúde

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